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Daniel B. Longley
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Journal Articles

Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists

Vera Grinkevitch, Mark Wappett, Nyree Crawford, Stacey Price, Andrea Lees, Christopher McCann, Katherine McAllister, Jochen Prehn, Jamie Young, Jess Bateson, Lewis Gallagher, Magali Michaut, Vivek Iyer, Aikaterini Chatzipli, Syd Barthorpe, Daniel Ciznadija, Ido Sloma, Amy Wesa, David A. Tice, Lodewyk Wessels, Mathew Garnett, Daniel B. Longley, Ultan McDermott, Simon S. McDade
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (4): 594–606.
https://doi.org/10.1158/1535-7163.MCT-21-0532
Published: 01 April 2022
View article titled, Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
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Includes: Supplementary data
Journal Articles

Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer

Nyree Crawford, Katie J. Stott, Tamas Sessler, Christopher McCann, William McDaid, Andrea Lees, Cheryl Latimer, Jennifer P. Fox, Joanne M. Munck, Tomoko Smyth, Alpesh Shah, Vanessa Martins, Mark Lawler, Philip D. Dunne, Emma M. Kerr, Simon S. McDade, Vicky M. Coyle, Daniel B. Longley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (9): 1627–1639.
https://doi.org/10.1158/1535-7163.MCT-20-1050
Published: 01 September 2021
View article titled, Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer
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Journal Articles

Abstract B129: Development and preclinical assessment of a first-in-class small-molecule inhibitor of FLIP

Catherine A. Higgins, Joanna Majkut, Jennifer Fox, Luke Humphreys, Greti Espona Fiedler, Ray J. Boffey, Trevor R. Perrior, David Haigh, Timothy Harrison, Daniel B. Longley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): B129.
https://doi.org/10.1158/1535-7163.TARG-17-B129
Published: 01 January 2018
View article titled, Abstract B129: Development and preclinical assessment of a first-in-class small-molecule inhibitor of FLIP
Journal Articles

FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer

Kylie A. McLaughlin, Zsuzsanna Nemeth, Conor A. Bradley, Luke Humphreys, Izabela Stasik, Catherine Fenning, Joanna Majkut, Catherine Higgins, Nyree Crawford, Caitriona Holohan, Patrick G. Johnston, Timothy Harrison, Gerard G. Hanna, Karl T. Butterworth, Kevin M. Prise, Daniel B. Longley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (10): 2432–2441.
https://doi.org/10.1158/1535-7163.MCT-16-0211
Published: 02 October 2016
View article titled, FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract C4: Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP for treatment of NSCLC

Joanna Majkut, Catherine Higgins, Adnan Malik, Zsusannah Nemeth, Peter Blurton, Ray J. Boffey, Trevor R. Perrior, David Haigh, Timothy Harrison, Daniel B. Longley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C4.
https://doi.org/10.1158/1535-7163.TARG-15-C4
Published: 01 December 2015
View article titled, Abstract C4: Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP for treatment of NSCLC
Journal Articles

Abstract C5: FLIP protein-protein interaction inhibitors enhance sensitivity of colorectal cancer cells to chemotherapy and TRAIL

Jennifer P. Fox, Joanna Majkut, Catherine Higgins, Zsuzsanna Nemeth, Adnan Malik, Christopher J. Scott, Peter Blurton, Ray J. Boffey, Trevor R. Perrior, Timothy Harrison, Daniel B. Longley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C5.
https://doi.org/10.1158/1535-7163.TARG-15-C5
Published: 01 December 2015
View article titled, Abstract C5: FLIP protein-protein interaction inhibitors enhance sensitivity of colorectal cancer cells to chemotherapy and TRAIL
Journal Articles

Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells

Wendy L. Allen, Richard C. Turkington, Leanne Stevenson, Gail Carson, Vicky M. Coyle, Suzanne Hector, Philip Dunne, Sandra Van Schaeybroeck, Daniel B. Longley, Patrick G. Johnston
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (8): 1724–1734.
https://doi.org/10.1158/1535-7163.MCT-12-0207
Published: 08 August 2012
View article titled, Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
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Includes: Supplementary data
Journal Articles

A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer

Wendy L. Allen, Leanne Stevenson, Vicky M. Coyle, Puthen V. Jithesh, Irina Proutski, Gail Carson, Michael A. Gordon, Heinz-Josef D. Lenz, Sandra Van Schaeybroeck, Daniel B. Longley, Patrick G. Johnston
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (1): 119–131.
https://doi.org/10.1158/1535-7163.MCT-11-0510
Published: 09 January 2012
View article titled, A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Abstract C12: Preclinical characterization of a novel FLIP‐targeted antisense phosphorothioate oligonucleotide

Andrew E. Logan, Timothy R. Wilson, Patrick G. Johnston, Daniel B. Longley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C12.
https://doi.org/10.1158/1535-7163.TARG-09-C12
Published: 10 December 2009
View article titled, Abstract C12: Preclinical characterization of a novel FLIP‐targeted antisense phosphorothioate oligonucleotide
Journal Articles

Prostate-derived factor—a novel inhibitor of drug-induced cell death in colon cancer cells

Irina Proutski, Leanne Stevenson, Wendy L. Allen, Andrea McCulla, John Boyer, Estelle G. McLean, Daniel B. Longley, Patrick G. Johnston
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (9): 2566–2574.
https://doi.org/10.1158/1535-7163.MCT-09-0158
Published: 17 September 2009
View article titled, Prostate-derived factor—a novel inhibitor of drug-induced cell death in colon cancer cells
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Includes: Supplementary data
Journal Articles

Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells

Catherine Wilson, Timothy Wilson, Patrick G. Johnston, Daniel B. Longley, David J.J. Waugh
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2649–2661.
https://doi.org/10.1158/1535-7163.MCT-08-0148
Published: 11 September 2008
View article titled, Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
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Journal Articles

Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells

Katherine M.A. Rogers, Michelle Thomas, Leeona Galligan, Timothy R. Wilson, Wendy L. Allen, Hidekazu Sakai, Patrick G. Johnston, Daniel B. Longley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (5): 1544–1551.
https://doi.org/10.1158/1535-7163.MCT-06-0673
Published: 18 May 2007
View article titled, Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells
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Journal Articles

The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells

Wendy L. Allen, Estelle G. McLean, John Boyer, Andrea McCulla, Peter M. Wilson, Vicky Coyle, Daniel B. Longley, Robert A. Casero, Jr., Patrick G. Johnston
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (1): 128–137.
https://doi.org/10.1158/1535-7163.MCT-06-0303
Published: 19 January 2007
View article titled, The role of spermidine/spermine <em>N</em><sup>1</sup>-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells
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Journal Articles

Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non–small cell lung cancer cells

Sandra Van Schaeybroeck, Joan Kyula, Donal M. Kelly, Anthi Karaiskou-McCaul, Susan A. Stokesberry, Eric Van Cutsem, Daniel B. Longley, Patrick G. Johnston
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (5): 1154–1165.
https://doi.org/10.1158/1535-7163.MCT-05-0446
Published: 26 May 2006
View article titled, Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non–small cell lung cancer cells
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Journal Articles

Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP

Leeona Galligan, Daniel B. Longley, Miranda McEwan, Timothy R. Wilson, Kirsty McLaughlin, Patrick G. Johnston
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (12): 2026–2036.
https://doi.org/10.1158/1535-7163.MCT-05-0262
Published: 22 December 2005
View article titled, Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP
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