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Dajun Yang
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Journal Articles

Abstract P208: Synergistic antitumor activity of lisaftoclax (APG-2575) and alrizomadlin (APG-115) through dual targeting of BCL-2/MDM2-P53 apoptotic pathways in preclinical models of acute myeloid leukemia

Free
Douglas D. Fang, Qiuqiong Tang, Qixin Wang, Na Li, Feng Zhou, Guoqin Zhai, Yan Yin, Dajun Yang, Yifan Zhai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P208.
https://doi.org/10.1158/1535-7163.TARG-21-P208
Published: 01 December 2021
View articletitled, Abstract P208: Synergistic antitumor activity of lisaftoclax (APG-2575) and alrizomadlin (APG-115) through dual targeting of BCL-2/MDM2-P53 apoptotic pathways in preclinical models of acute myeloid leukemia
Journal Articles

Abstract P209: Collaborative crosstalk between two apoptosis pathways drives synergy of dual inhibition of BCL-2/MDM2 in preclinical models of neuroblastoma

Free
Douglas D. Fang, Qiuqiong Tang, Qixin Wang, Yanhui Kong, Na Li, Feng Zhou, Ran Tao, Dajun Yang, Yifan Zhai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P209.
https://doi.org/10.1158/1535-7163.TARG-21-P209
Published: 01 December 2021
View articletitled, Abstract P209: Collaborative crosstalk between two apoptosis pathways drives synergy of dual inhibition of BCL-2/MDM2 in preclinical models of neuroblastoma
Journal Articles

Abstract A086: Phase Ib study of a novel MDM2 inhibitor APG-115, in combination with pembrolizumab in patients with metastatic solid tumors in U.S.

Free
Anthony W Tolcher, Raghad Karim, Yuefen Tang, Jiao Ji, Hengbang Wang, Lichuang Meng, Angela Kaiser, Jennifer Coe, Eric Liang, Christina Rosas, Dajun Yang, Yifan Zhai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): A086.
https://doi.org/10.1158/1535-7163.TARG-19-A086
Published: 01 December 2019
View articletitled, Abstract A086: Phase Ib study of a novel MDM2 inhibitor APG-115, in combination with pembrolizumab in patients with metastatic solid tumors in U.S.
Journal Articles

Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma

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Man-si Wu, Guang-feng Wang, Zhi-qiang Zhao, Yi Liang, Heng-bang Wang, Miao-yi Wu, Ping Min, Li-zhen Chen, Qi-sheng Feng, Jin-xin Bei, Yi-xin Zeng, Dajun Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (9): 1728–1737.
https://doi.org/10.1158/1535-7163.MCT-13-0017
Published: 05 September 2013
View articletitled, Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma
Open the PDF for Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma in another window
Includes: Supplementary data
Journal Articles

In vivo tumor regression achieved by a potent bivalent Smac mimetic (SM-164) in combination with TRAIL

Free
jianfeng lu, Haiying Sun, Donna McEachern, Rebecca Miller, Su Qiu, Han Yi, Zeneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C228.
Published: 01 November 2007
View articletitled, In vivo tumor regression achieved by a potent bivalent Smac mimetic (SM-164) in combination with TRAIL
Journal Articles

BI-33, a novel and potent pan-Bcl-2 inhibitor, induces apoptosis in cancer cells and shows combinational effect with chemo drugs

Free
Feng Jiang, Jianting Long, Sanjeev Shangary, Su Qiu, Meilan Liu, Guozhi Tang, ke Ding, Zaneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C229.
Published: 01 November 2007
View articletitled, BI-33, a novel and potent pan-Bcl-2 inhibitor, induces apoptosis in cancer cells and shows combinational effect with chemo drugs
Journal Articles

Preclinical studies of orally active, pan Bcl-2 small molecule inhibitor AT-101 in small cell lung cancer.

Free
Guangfeng Wang, Ping Min, Yan Zhang, Xinyan Ni, Ting Zhang, Nathalie Bruey-Sedano, Dajun Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A51.
Published: 01 November 2007
View articletitled, Preclinical studies of orally active, pan Bcl-2 small molecule inhibitor AT-101 in small cell lung cancer.
Journal Articles

In vivo efficacy of AT-101, an orally active pan Bcl-2 family protein inhibitor in combination with docetaxel or erlotinib for non small cell lung cancer therapy

Free
Ting Zhang, Guangfeng Wang, Ping Min, Yan Zhang, Xinyan Ni, Jinxia Mi, Nathalie Bruey-Sedano, Dajun Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A44.
Published: 01 November 2007
View articletitled, In vivo efficacy of AT-101, an orally active pan Bcl-2 family protein inhibitor in combination with docetaxel or erlotinib for non small cell lung cancer therapy
Journal Articles

A novel orally active MDM2 inhibitor (MI-219) activates the p53 pathway and is selectively toxic to tumor cells

Free
Sanjeev Shangary, Dongguang Qin, Donna McEachern, Rebecca Miller, Zaneta Nikolovska-Coleska, Meilan Liu, Su Qiu, Ke Ding, Guoping Wang, Jianyong Chen, Yipin Lu, Denzil Bernard, Qingyang Gu, Yi Sun, Rajal Shah, Kenneth Pienta, Xiaolan Lin, Sanmao Kang, Shuguang Zhu, Ming Guo, Dajun Yang, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B271.
Published: 01 November 2007
View articletitled, A novel orally active MDM2 inhibitor (MI-219) activates the p53 pathway and is selectively toxic to tumor cells
Journal Articles

(−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer

Free
Liang Xu, Dajun Yang, Shaomeng Wang, Wenhua Tang, Meilan Liu, Mary Davis, Jianyong Chen, James M. Rae, Theodore Lawrence, Marc E. Lippman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (2): 197–205.
https://doi.org/10.1158/1535-7163.197.4.2
Published: 15 February 2005
View articletitled, (−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer
Open the PDF for (−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer in another window