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Constantine S. Mitsiades
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Journal Articles

M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models

Open Access
Michael P. Sanderson, Manja Friese-Hamim, Gina Walter-Bausch, Michael Busch, Stefanie Gaus, Djordje Musil, Felix Rohdich, Ugo Zanelli, Sondra L. Downey-Kopyscinski, Constantine S. Mitsiades, Oliver Schadt, Markus Klein, Christina Esdar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (8): 1378–1387.
https://doi.org/10.1158/1535-7163.MCT-21-0005
Published: 01 August 2021
View article titled, M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models
Open the PDF for M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models in another window
Includes: Supplementary data
Journal Articles

The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma

Free
Ronan Le Moigne, Blake T. Aftab, Stevan Djakovic, Eugen Dhimolea, Eduardo Valle, Megan Murnane, Emily M. King, Ferdie Soriano, Mary-Kamala Menon, Zhi Yong Wu, Stephen T. Wong, Grace J. Lee, Bing Yao, Arun P. Wiita, Christine Lam, Julie Rice, Jinhai Wang, Marta Chesi, P. Leif Bergsagel, Marianne Kraus, Christoph Driessen, Szerenke Kiss Von Soly, F. Michael Yakes, David Wustrow, Laura Shawver, Han-Jie Zhou, Thomas G. Martin, III, Jeffrey L. Wolf, Constantine S. Mitsiades, Daniel J. Anderson, Mark Rolfe
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (11): 2375–2386.
https://doi.org/10.1158/1535-7163.MCT-17-0233
Published: 01 November 2017
View article titled, The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma
Open the PDF for The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Abstract C283: Non-malignant cells from tissues targeted by metastatic breast cancer induce tumor cell resistance to antiestrogens and conventional chemotherapeutic agents.

Free
Eugen Dhimolea, Richard W.J. Groen, Kornelia Polyak, Constantine S. Mitsiades
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C283.
https://doi.org/10.1158/1535-7163.TARG-13-C283
Published: 01 November 2013
View article titled, Abstract C283: Non-malignant cells from tissues targeted by metastatic breast cancer induce tumor cell resistance to antiestrogens and conventional chemotherapeutic agents.
Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Free
Richard J. Rickles, Winnie F. Tam, Thomas P. Giordano, III, Laura T. Pierce, Melissa Farwell, Douglas W. McMillin, Antoaneta Necheva, David Crowe, Mei Chen, William Avery, Vikram Kansra, Steffan T. Nawrocki, Jennifer S. Carew, Francis J. Giles, Constantine S. Mitsiades, Alexis A. Borisy, Kenneth C. Anderson, Margaret S. Lee
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (7): 1432–1442.
https://doi.org/10.1158/1535-7163.MCT-11-0925
Published: 05 July 2012
View article titled, Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening
Open the PDF for Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening in another window
Includes: Supplementary data
Journal Articles

Molecular and Cellular Effects of NEDD8-Activating Enzyme Inhibition in Myeloma

Free
Douglas W. McMillin, Hannah M. Jacobs, Jake E. Delmore, Leutz Buon, Zachary R. Hunter, Val Monrose, Jie Yu, Peter G. Smith, Paul G. Richardson, Kenneth C. Anderson, Steven P. Treon, Andrew L. Kung, Constantine S. Mitsiades
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (4): 942–951.
https://doi.org/10.1158/1535-7163.MCT-11-0563
Published: 08 April 2012
View article titled, Molecular and Cellular Effects of NEDD8-Activating Enzyme Inhibition in Myeloma
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Includes: Supplementary data
Journal Articles

Targeting BRAFV600E in thyroid carcinoma: therapeutic implications

Free
Constantine S. Mitsiades, Joseph Negri, Ciaran McMullan, Douglas W. McMillin, Elias Sozopoulos, Galinos Fanourakis, Gerassimos Voutsinas, Sophia Tseleni-Balafouta, Vassiliki Poulaki, David Batt, Nicholas Mitsiades
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (3): 1070–1078.
https://doi.org/10.1158/1535-7163.MCT-06-0449
Published: 15 March 2007
View article titled, Targeting BRAFV600E in thyroid carcinoma: therapeutic implications
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