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Journal Articles

HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors

Mary E. Molloy, Wade H. Aaron, Manasi Barath, Mabel C. Bush, Evan C. Callihan, Kevin Carlin, Michael Cremin, Thomas Evans, Maria G. Guerrero, Golzar Hemmati, Avneel S. Hundal, Llewelyn Lao, Payton Laurie, Bryan D. Lemon, S.J. Lin, Jessica O’Rear, Purbasa Patnaik, Sony Sotelo Rocha, Linda Santiago, Kathryn L. Strobel, Laura B. Valenzuela, Chi-Heng Wu, Stephen Yu, Timothy Z. Yu, Banmeet S. Anand, Che-Leung Law, Liping L. Sun, Holger Wesche, Richard J. Austin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (9): 1294–1304.
https://doi.org/10.1158/1535-7163.MCT-23-0524
Published: 04 September 2024
View article titled, HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Open the PDF for HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity

Ryan A. Heiser, Anthony T. Cao, Weiping Zeng, Michelle Ulrich, Patrick Younan, Martha E. Anderson, Esther S. Trueblood, Mechthild Jonas, Robert Thurman, Che-Leung Law, Shyra J. Gardai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (1): 68–83.
https://doi.org/10.1158/1535-7163.MCT-23-0118
Published: 03 January 2024
View article titled, Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity
Open the PDF for Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors

Richard J. Austin, Bryan D. Lemon, Wade H. Aaron, Manasi Barath, Patricia A. Culp, Robert B. DuBridge, Luke B. Evnin, Adrie Jones, Anand Panchal, Purbasa Patnaik, Vanitha Ramakrishnan, Sony S. Rocha, Pui Seto, Kenneth Sexton, Kathryn L. Strobel, Russell Wall, Stephen Yu, Timothy Z. Yu, Che-Leung Law, Patrick A. Baeuerle, Holger Wesche
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2021) 20 (1): 109–120.
https://doi.org/10.1158/1535-7163.MCT-20-0061
Published: 05 January 2021
View article titled, TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors
Open the PDF for TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract C033: HPN328: An anti-DLL3 T cell engager for treatment of small cell lung cancer

Wade H Aaron, Richard Austin, Manasi Barath, Evan Callihan, Michael Cremin, Thomas Evans, Maria Gamez, Vaishnavi Ganti, Golzar Hemmati, Kathryn Kwant, Che-Leung Law, Bryan Lemon, Llewelyn Lao, Mary Ellen Molloy, Jessica O’Rear, Laura Sun, Holger Wesche, Stephen Yu, Timothy Yu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C033.
https://doi.org/10.1158/1535-7163.TARG-19-C033
Published: 01 December 2019
View article titled, Abstract C033: HPN328: An anti-DLL3 T cell engager for treatment of small cell lung cancer
Journal Articles

Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia

Fu Li, May Kung Sutherland, Changpu Yu, Roland B. Walter, Lori Westendorf, John Valliere-Douglass, Lucy Pan, Ashley Cronkite, Django Sussman, Kerry Klussman, Michelle Ulrich, Martha E. Anderson, Ivan J. Stone, Weiping Zeng, Mechthild Jonas, Timothy S. Lewis, Maitrayee Goswami, Sa A. Wang, Peter D. Senter, Che-Leung Law, Eric J. Feldman, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (2): 554–564.
https://doi.org/10.1158/1535-7163.MCT-17-0742
Published: 01 February 2018
View article titled, Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia
Open the PDF for Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates

Fu Li, Michelle Ulrich, Mechthild Jonas, Ivan J. Stone, Germein Linares, Xinqun Zhang, Lori Westendorf, Dennis R. Benjamin, Che-Leung Law
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (7): 1347–1354.
https://doi.org/10.1158/1535-7163.MCT-17-0019
Published: 04 July 2017
View article titled, Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates
Open the PDF for Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates in another window
Includes: Supplementary data
Journal Articles

Abstract C52: Enhancing the activities of endogenous antibodies.

Stephen Alley, Dennis Benjamin, Kim Emmerton, Xinqun Zhang, Che-Leung Law, Nicole Okeley, Peter Senter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): C52.
https://doi.org/10.1158/1535-7163.TARG-11-C52
Published: 12 November 2011
View article titled, Abstract C52: Enhancing the activities of endogenous antibodies.
Journal Articles

The humanized anti-CD40 monoclonal antibody, SGN-40, signals apoptosis in non-Hodgkin's lymphoma by dual mechanisms

Renee McCormick, Timothy Lewis, Jamie Miyamoto, May Sutherland, Jonathan Drachman, Iqbal Grewal, Che-Leung Law
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B63.
Published: 01 November 2007
View article titled, The humanized anti-CD40 monoclonal antibody, SGN-40, signals apoptosis in non-Hodgkin's lymphoma by dual mechanisms
Journal Articles

Humanized anti-CD19 auristatin antibody-drug conjugates display potent antitumor activity in preclinical models of B-cell malignancies

Hans-Peter Gerber, Carol Morris-Tilden, Ivan Stone, Mechthild Jonas, May Kung-Sutherland, Jamie Miyamoto, Lindsay Brown, Lori Westendorf, Damon Meyer, Django Sussman, Paul Carter, Che-Leung Law, Iqbal Grewal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B60.
Published: 01 November 2007
View article titled, Humanized anti-CD19 auristatin antibody-drug conjugates display potent antitumor activity in preclinical models of B-cell malignancies