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Charles Ginther
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Journal Articles

Therapeutic Potential of the Poly(ADP-ribose) Polymerase Inhibitor Rucaparib for the Treatment of Sporadic Human Ovarian Cancer

Maike Ihnen, Christine zu Eulenburg, Teodora Kolarova, Jing Wei Qi, Kanthinh Manivong, Meenal Chalukya, Judy Dering, Lee Anderson, Charles Ginther, Alexandra Meuter, Boris Winterhoff, Siân Jones, Victor E. Velculescu, Natarajan Venkatesan, Hong-Mei Rong, Sugandha Dandekar, Nitin Udar, Fritz Jänicke, Gerrit Los, Dennis J. Slamon, Gottfried E. Konecny
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (6): 1002–1015.
https://doi.org/10.1158/1535-7163.MCT-12-0813
Published: 09 June 2013
View article titled, Therapeutic Potential of the Poly(ADP-ribose) Polymerase Inhibitor Rucaparib for the Treatment of Sporadic Human Ovarian Cancer
Open the PDF for Therapeutic Potential of the Poly(ADP-ribose) Polymerase Inhibitor Rucaparib for the Treatment of Sporadic Human Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib

Ondrej Kalous, Dylan Conklin, Amrita J. Desai, Neil A. O'Brien, Charles Ginther, Lee Anderson, David J. Cohen, Carolyn D. Britten, Ian Taylor, James G. Christensen, Dennis J. Slamon, Richard S. Finn
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (9): 1978–1987.
https://doi.org/10.1158/1535-7163.MCT-11-0730
Published: 06 September 2012
View article titled, Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib
Open the PDF for Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib in another window
Includes: Supplementary data
Journal Articles

Identification of Common Predictive Markers of In vitro Response to the Mek Inhibitor Selumetinib (AZD6244; ARRY-142886) in Human Breast Cancer and Non–Small Cell Lung Cancer Cell Lines

Edward B. Garon, Richard S. Finn, Wylie Hosmer, Judy Dering, Charles Ginther, Shahriar Adhami, Naeimeh Kamranpour, Sharon Pitts, Amrita Desai, David Elashoff, Tim French, Paul Smith, Dennis J. Slamon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (7): 1985–1994.
https://doi.org/10.1158/1535-7163.MCT-10-0037
Published: 07 July 2010
View article titled, Identification of Common Predictive Markers of <em>In vitro</em> Response to the Mek Inhibitor Selumetinib (AZD6244; ARRY-142886) in Human Breast Cancer and Non–Small Cell Lung Cancer Cell Lines
Open the PDF for Identification of Common Predictive Markers of <em>In vitro</em> Response to the Mek Inhibitor Selumetinib (AZD6244; ARRY-142886) in Human Breast Cancer and Non–Small Cell Lung Cancer Cell Lines in another window
Includes: Supplementary data
Journal Articles

Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib

Neil A. O'Brien, Brigid C. Browne, Lucy Chow, Yuhua Wang, Charles Ginther, Jane Arboleda, Michael J. Duffy, John Crown, Norma O'Donovan, Dennis J. Slamon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (6): 1489–1502.
https://doi.org/10.1158/1535-7163.MCT-09-1171
Published: 09 June 2010
View article titled, Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib
Open the PDF for Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib in another window
Includes: Supplementary data
Journal Articles

Abstract B232: Preclinical evaluation of AMG479 a fully human insulin‐like growth factor receptor‐1 (IGFR1) antibody in ovarian cancer cells

Gottfried E. Konecny, Kanthinh Manivong, Ellen Guorong, Ruth Glas, Judy Dering, Lee Anderson, Charles Ginther, Victor Velculescu, Frank Calzone, Dennis J. Slamon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B232.
https://doi.org/10.1158/1535-7163.TARG-09-B232
Published: 10 December 2009
View article titled, Abstract B232: Preclinical evaluation of AMG479 a fully human insulin‐like growth factor receptor‐1 (IGFR1) antibody in ovarian cancer cells