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Journal Articles

Abstract CN08-03: Liquid biopsies for the management of cancer patient treatment and for early detection of cancer

Caroline Dive

Mol Cancer Ther (2018) 17 (1_Supplement): CN08-03.

https://doi.org/10.1158/1535-7163.TARG-17-CN08-03

Published: 01 January 2018

View article titled, Abstract CN08-03: Liquid biopsies for the management of cancer patient treatment and for early detection of cancer

Journal Articles

Abstract A185: Combining unbiased network analysis and cancer genomics to guide precision medicine-oriented early-phase clinical trials

Pedro Torres-Ayuso, Sudhakar Sahoo, Christopher Chester, Cassandra Hodgkinson, Melanie Galvin, Hui Sun Leong, Kristopher Frese, Richard Marais, Caroline Dive, Matthew Krebs, John Brognard

Mol Cancer Ther (2018) 17 (1_Supplement): A185.

https://doi.org/10.1158/1535-7163.TARG-17-A185

Published: 01 January 2018

View article titled, Abstract A185: Combining unbiased network analysis and cancer genomics to guide precision medicine-oriented early-phase clinical trials

Journal Articles

Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC

Danielle S. Potter, Melanie Galvin, Stewart Brown, Alice Lallo, Cassandra L. Hodgkinson, Fiona Blackhall, Christopher J. Morrow, Caroline Dive

Mol Cancer Ther (2016) 15 (6): 1248–1260.

https://doi.org/10.1158/1535-7163.MCT-15-0885

Published: 02 June 2016

View article titled, Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC

Includes: Supplementary data

Journal Articles

Abstract CN07-01: Using CTCs to improve outcomes in SCLC: Single cell profiling, ex vivo cultures, and mouse models

Caroline Dive

Mol Cancer Ther (2015) 14 (12_Supplement_2): CN07-01.

https://doi.org/10.1158/1535-7163.TARG-15-CN07-01

Published: 01 December 2015

View article titled, Abstract CN07-01: Using CTCs to improve outcomes in SCLC: Single cell profiling, ex vivo cultures, and mouse models

Journal Articles

Abstract A176: RET inhibition: Development of novel compounds and a personalized medicine strategy in lung adenocarcinoma

Mandy Watson, Helen Small, Phil Chapman, Gemma Hopkins, Habiba Begum, Ian D. Waddell, Garry Ashton, Caron Abbey, Jade Harris, Mahmood Ayub, Sumitra Mohan, Dominic Rothwell, Ged Brady, Caroline Dive, Allan Jordan, Donald Ogilvie

Mol Cancer Ther (2015) 14 (12_Supplement_2): A176.

https://doi.org/10.1158/1535-7163.TARG-15-A176

Published: 01 December 2015

View article titled, Abstract A176: RET inhibition: Development of novel compounds and a personalized medicine strategy in lung adenocarcinoma

Journal Articles

Abstract CN02-01: CTCs in small cell lung cancer: Biomarkers and biology.

Caroline Dive

Mol Cancer Ther (2013) 12 (11_Supplement): CN02-01.

https://doi.org/10.1158/1535-7163.TARG-13-CN02-01

Published: 01 November 2013

View article titled, Abstract CN02-01: CTCs in small cell lung cancer: Biomarkers and biology.

Journal Articles

[¹⁸F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Christopher Cawthorne, Natalie Burrows, Roben G. Gieling, Christopher J. Morrow, Duncan Forster, Jamil Gregory, Marc Radigois, Alison Smigova, Muhammad Babur, Kathryn Simpson, Cassandra Hodgkinson, Gavin Brown, Adam McMahon, Caroline Dive, Duncan Hiscock, Ian Wilson, Kaye J. Williams

Mol Cancer Ther (2013) 12 (5): 819–828.

https://doi.org/10.1158/1535-7163.MCT-12-0905

Published: 08 May 2013

View article titled, [<sup>18</sup>F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Includes: Supplementary data

Journal Articles

The Novel Bcl-2 Inhibitor ABT-737 Is More Effective in Hypoxia and Is Able to Reverse Hypoxia-Induced Drug Resistance in Neuroblastoma Cells

Tetyana Klymenko, Martin Brandenburg, Christopher Morrow, Caroline Dive, Guy Makin

Mol Cancer Ther (2011) 10 (12): 2373–2383.

https://doi.org/10.1158/1535-7163.MCT-11-0326

Published: 07 December 2011

View article titled, The Novel Bcl-2 Inhibitor ABT-737 Is More Effective in Hypoxia and Is Able to Reverse Hypoxia-Induced Drug Resistance in Neuroblastoma Cells

Includes: Supplementary data

Journal Articles

Abstract CN02-02: CTCs as pharmacodynamic and /or predictive biomarkers

Caroline Dive, Jian Mei Hou, Matthew Krebs, Malcolm Ranson, Andrew Hughes, Tim Ward, Fiona Blackhall

Mol Cancer Ther (2009) 8 (12_Supplement): CN02-02.

https://doi.org/10.1158/1535-7163.TARG-09-CN02-02

Published: 10 December 2009

View article titled, Abstract CN02-02: CTCs as pharmacodynamic and /or predictive biomarkers

Journal Articles

Abstract C184: Validation of an ELISA for the determination of Rituximab pharmacokinetics in clinical trials subjects

Tim H. Ward, Grace Hampson, Jeff Cummings, Mike Bayne, Alison Tutt, Mark Cragg, Caroline Dive, Tim Illidge

Mol Cancer Ther (2009) 8 (12_Supplement): C184.

https://doi.org/10.1158/1535-7163.TARG-09-C184

Published: 10 December 2009

View article titled, Abstract C184: Validation of an ELISA for the determination of Rituximab pharmacokinetics in clinical trials subjects

Journal Articles

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Jeffrey Cummings, Cassandra Hodgkinson, Rajesh Odedra, Patrizia Sini, Simon P. Heaton, Kirsten E. Mundt, Tim H. Ward, Robert W. Wilkinson, Jim Growcott, Andrew Hughes, Caroline Dive

Mol Cancer Ther (2008) 7 (3): 455–463.

https://doi.org/10.1158/1535-7163.MCT-07-2136

Published: 17 March 2008

View article titled, Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Journal Articles

Utility of circulating biomarkers of cell death in disseminated testicular cancer patients treated with standard platinum-based chemotherapy

Kathryn Taylor, Esther de Haas, Alessandra di Pietro, Coby Meijer, Lee Lancashire, Jeff Cummings, Stephan de Jong, Elisabeth de Vries, Caroline Dive, Jourik Gietema

Mol Cancer Ther (2007) 6 (11_Supplement): C47.

Published: 01 November 2007

View article titled, Utility of circulating biomarkers of cell death in disseminated testicular cancer patients treated with standard platinum-based chemotherapy

Journal Articles

Hypoxia increases the sensitivity of small cell lung cancer, colorectal cancer and neuroblastoma cells to the BH-3 mimetic ABT-737

Dimitra Micha, Martin Brandenburg, Clare Dempsey, Darren Roberts, Guy Makin, Kathryn Taylor, Saul Rosenberg, Caroline Dive

Mol Cancer Ther (2007) 6 (11_Supplement): B30.

Published: 01 November 2007

View article titled, Hypoxia increases the sensitivity of small cell lung cancer, colorectal cancer and neuroblastoma cells to the BH-3 mimetic ABT-737

Journal Articles

An inducible caspase-3 “tumor death switch” model to identify circulating biomarkers of apoptotic cell death and test novel imaging probes for apoptosis.

Kathryn Taylor, Cassandra Hodgkinson, Martin Dawson, Lee Lancashire, Arek Welman, Christopher Cawthorne, Marion MacFarlane, Caroline Dive

Mol Cancer Ther (2007) 6 (11_Supplement): A49.

Published: 01 November 2007

View article titled, An inducible caspase-3 “tumor death switch” model to identify circulating biomarkers of apoptotic cell death and test novel imaging probes for apoptosis.

Journal Articles

Effects of combining the potent Src inhibitor AZD0530 with conventional cytotoxic agents in colorectal cancer cells in vitro

Christopher Morrow, Elvin Wagenblast, Juliana Bales, Tim Ward, Tim Green, Caroline Dive

Mol Cancer Ther (2007) 6 (11_Supplement): A245.

Published: 01 November 2007

View article titled, Effects of combining the potent Src inhibitor AZD0530 with conventional cytotoxic agents in colorectal cancer cells <em>in vitro</em>

Journal Articles

Cell death ELISAs in the phase I clinical evaluation of AEG35156 (XIAP antisense) administered as an intravenous infusion over 7-days, 3-days, and 2-hours.

Malcolm Ranson, Emma Dean, Tim Ward, Jeff Cummings, Lesley Robson, Jon Durkin, Jacques Jolivet, Duncan Jodrell, Caroline Dive

Mol Cancer Ther (2007) 6 (11_Supplement): C163.

Published: 01 November 2007

View article titled, Cell death ELISAs in the phase I clinical evaluation of AEG35156 (XIAP antisense) administered as an intravenous infusion over 7-days, 3-days, and 2-hours.

Journal Articles

Contribution of HIF-1 and drug penetrance to hypoxia- mediated oxaliplatin resistance in colorectal cancer spheroids

Darren Roberts, Kaye Williams, Rachel Cowen, Michael Tilby, D Graham Pearson, Christopher Ottley, Ian Stratford, Caroline Dive

Mol Cancer Ther (2007) 6 (11_Supplement): A198.

Published: 01 November 2007

View article titled, Contribution of HIF-1 and drug penetrance to hypoxia- mediated oxaliplatin resistance in colorectal cancer spheroids

Journal Articles

Investigating the impact of PI3-kinase inhibition on colorectal cancer cell growth and responsive to Oxaliplatin using an inducible genetic model.

Cristina Martin Fernandez, Juliana Bales, Arkadiusz Welman, Caroline Dive, Christopher Morrow

Mol Cancer Ther (2007) 6 (11_Supplement): C13.

Published: 01 November 2007

View article titled, Investigating the impact of PI3-kinase inhibition on colorectal cancer cell growth and responsive to Oxaliplatin using an inducible genetic model.

Journal Articles

Downregulation of XIAP expression induces apoptosis and sensitizes a panel of pediatric tumor cells to cytotoxic agents

Sarah Holt, Karen Brookes, Jon Durkin, Caroline Dive, Guy Makin

Mol Cancer Ther (2007) 6 (11_Supplement): B25.

Published: 01 November 2007

View article titled, Downregulation of XIAP expression induces apoptosis and sensitizes a panel of pediatric tumor cells to cytotoxic agents

Journal Articles

Chronic hypoxia promotes hypoxia-inducible factor-1α–dependent resistance to etoposide and vincristine in neuroblastoma cells

Deema Hussein, Edward J. Estlin, Caroline Dive, Guy W.J. Makin

Mol Cancer Ther (2006) 5 (9): 2241–2250.

https://doi.org/10.1158/1535-7163.MCT-06-0145

Published: 19 September 2006

View article titled, Chronic hypoxia promotes hypoxia-inducible factor-1α–dependent resistance to etoposide and vincristine in neuroblastoma cells

NARROW

Abstract CN08-03: Liquid biopsies for the management of cancer patient treatment and for early detection of cancer

Abstract A185: Combining unbiased network analysis and cancer genomics to guide precision medicine-oriented early-phase clinical trials

Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC

Abstract CN07-01: Using CTCs to improve outcomes in SCLC: Single cell profiling, ex vivo cultures, and mouse models

Abstract A176: RET inhibition: Development of novel compounds and a personalized medicine strategy in lung adenocarcinoma

Abstract CN02-01: CTCs in small cell lung cancer: Biomarkers and biology.

[¹⁸F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

The Novel Bcl-2 Inhibitor ABT-737 Is More Effective in Hypoxia and Is Able to Reverse Hypoxia-Induced Drug Resistance in Neuroblastoma Cells

Abstract CN02-02: CTCs as pharmacodynamic and /or predictive biomarkers

Abstract C184: Validation of an ELISA for the determination of Rituximab pharmacokinetics in clinical trials subjects

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Utility of circulating biomarkers of cell death in disseminated testicular cancer patients treated with standard platinum-based chemotherapy

Hypoxia increases the sensitivity of small cell lung cancer, colorectal cancer and neuroblastoma cells to the BH-3 mimetic ABT-737

An inducible caspase-3 “tumor death switch” model to identify circulating biomarkers of apoptotic cell death and test novel imaging probes for apoptosis.

Effects of combining the potent Src inhibitor AZD0530 with conventional cytotoxic agents in colorectal cancer cells in vitro

Cell death ELISAs in the phase I clinical evaluation of AEG35156 (XIAP antisense) administered as an intravenous infusion over 7-days, 3-days, and 2-hours.

Contribution of HIF-1 and drug penetrance to hypoxia- mediated oxaliplatin resistance in colorectal cancer spheroids

Investigating the impact of PI3-kinase inhibition on colorectal cancer cell growth and responsive to Oxaliplatin using an inducible genetic model.

Downregulation of XIAP expression induces apoptosis and sensitizes a panel of pediatric tumor cells to cytotoxic agents

Chronic hypoxia promotes hypoxia-inducible factor-1α–dependent resistance to etoposide and vincristine in neuroblastoma cells

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