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Brian D. Harms
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Journal Articles

MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors

Jonathan B. Fitzgerald, Bryan W. Johnson, Jason Baum, Sharlene Adams, Sergio Iadevaia, Jian Tang, Victoria Rimkunas, Lihui Xu, Neeraj Kohli, Rachel Rennard, Maja Razlog, Yang Jiao, Brian D. Harms, Kenneth J. Olivier, Jr, Birgit Schoeberl, Ulrik B. Nielsen, Alexey A. Lugovskoy
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2014) 13 (2): 410–425.
https://doi.org/10.1158/1535-7163.MCT-13-0255
Published: 09 February 2014
View article titled, MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors
Open the PDF for MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors in another window
Includes: Supplementary data
Journal Articles

Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies

Yu Zhou, Anne-Laure Goenaga, Brian D. Harms, Hao Zou, Jianlong Lou, Fraser Conrad, Gregory P. Adams, Birgit Schoeberl, Ulrik B. Nielsen, James D. Marks
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (7): 1467–1476.
https://doi.org/10.1158/1535-7163.MCT-11-1038
Published: 05 July 2012
View article titled, Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Open the PDF for Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies in another window
Includes: Supplementary data
Journal Articles

Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3

Charlotte F. McDonagh, Alexandra Huhalov, Brian D. Harms, Sharlene Adams, Violette Paragas, Shinji Oyama, Bo Zhang, Lia Luus, Ryan Overland, Stephanie Nguyen, Jinming Gu, Neeraj Kohli, Matt Wallace, Michael J. Feldhaus, Arthur J. Kudla, Birgit Schoeberl, Ulrik B. Nielsen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (3): 582–593.
https://doi.org/10.1158/1535-7163.MCT-11-0820
Published: 06 March 2012
View article titled, Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3
Open the PDF for Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3 in another window
Includes: Supplementary data