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Bissan Al-Lazikani
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Journal Articles

Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Open Access
Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M. Jiménez-Vacas, Victor Gourain, Irene I. Lee, Rebecca Seeger, Claudia Muhle-Goll, Bora Gurel, Jonathan Welti, Daniel Nava Rodrigues, Jan Rekowski, Xintao Qiu, Yija Jiang, Patrizio Di Micco, Borja Mateos, Stasė Bielskutė, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Mateus Crespo, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Stefan Bräse, Nicole Jung, Simone Gräßle, Amanda Swain, Xavier Salvatella, Stephen R. Plymate, Bissan Al-Lazikani, Henry W. Long, Wei Yuan, Myles Brown, Andrew C.B. Cato, Johann S. de Bono, Adam Sharp
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (6): 791–808.
https://doi.org/10.1158/1535-7163.MCT-23-0354
Published: 04 June 2024
View articletitled, Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer
Open the PDF for Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C059: Probabilistic graph-based model uncovers druggable vulnerabilities in major solid cancers

Free
Stephanie T Schmidt, Ying Zhu, Li Zhao, Chunjie Jiang, Patrizio Di Micco, Costas Mitsopoulos, Andrew Futreal, Bissan Al-Lazikani
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C059.
https://doi.org/10.1158/1535-7163.TARG-23-C059
Published: 01 December 2023
View articletitled, Abstract C059: Probabilistic graph-based model uncovers druggable vulnerabilities in major solid cancers
Journal Articles

Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes

Open Access
Elizabeth A. Coker, Adam Stewart, Bugra Ozer, Anna Minchom, Lisa Pickard, Ruth Ruddle, Suzanne Carreira, Sanjay Popat, Mary O'Brien, Florence Raynaud, Johann de Bono, Bissan Al-Lazikani, Udai Banerji
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 1020–1029.
https://doi.org/10.1158/1535-7163.MCT-21-0442
Published: 01 June 2022
View articletitled, Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
Open the PDF for Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes in another window
Includes: Supplementary data
Journal Articles

Abstract LB-C01: The kinase polypharmacology landscape of clinical PARP inhibitors

Free
Albert A Antolin, Malaka Ameratunga, Udai Banerji, Paul Clarke, Paul Workman, Bissan Al-Lazikani
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): LB-C01.
https://doi.org/10.1158/1535-7163.TARG-19-LB-C01
Published: 01 December 2019
View articletitled, Abstract LB-C01: The kinase polypharmacology landscape of clinical PARP inhibitors
Journal Articles

Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers

Free
Adam Stewart, Elizabeth A. Coker, Sebastian Pölsterl, Alexandros Georgiou, Anna R. Minchom, Suzanne Carreira, David Cunningham, Mary ER. O'Brien, Florence I. Raynaud, Johann S. de Bono, Bissan Al-Lazikani, Udai Banerji
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (8): 1396–1404.
https://doi.org/10.1158/1535-7163.MCT-18-0727
Published: 01 August 2019
View articletitled, Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers
Open the PDF for Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract A024: Probe Miner: objective, quantitative, data-driven assessment of chemical probes for target validation

Free
Albert A. Antolin, Joe E. Tym, Angeliki Komianou, Ian Collins, Paul Workman, Bissan Al-Lazikani
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A024.
https://doi.org/10.1158/1535-7163.TARG-17-A024
Published: 01 January 2018
View articletitled, Abstract A024: Probe Miner: objective, quantitative, data-driven assessment of chemical probes for target validation
Journal Articles

Abstract B096: canSAR, a cancer research and drug discovery knowledgebase

Free
Elizabeth A. Coker, Patrizio Di Micco, Joesph E. Tym, Costas Mitsopoulos, Angeliki Komianou, Albert A. Antolin, Bissan Al-Lazikani
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): B096.
https://doi.org/10.1158/1535-7163.TARG-17-B096
Published: 01 January 2018
View articletitled, Abstract B096: canSAR, a cancer research and drug discovery knowledgebase
Journal Articles

Abstract CN01-02: canSAR: An integrated cancer drug discovery informatics platform allowing systematic target evaluation.

Free
Bissan Al-Lazikani, Mishal Patel, Krishna Bulusu, Mark Halling-Brown
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): CN01-02.
https://doi.org/10.1158/1535-7163.TARG-11-CN01-02
Published: 12 November 2011
View articletitled, Abstract CN01-02: canSAR: An integrated cancer drug discovery informatics platform allowing systematic target evaluation.