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Abstract A084: Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRAS^G12C inhibitors that bind in the switch II pocket

Bin Wang, Alok Sharma, James Stice, Brian Smith, Marcin Dyba, Devansh Singh, John-Paul Denson, Dana Rabara, Erik Larsen, Yue Yang, Felice C Lightstone, Andrew Stephen, Dwight Nissley, Frank McCormick, Eli Wallace, Anna E Maciag, Pedro J Beltran

Mol Cancer Ther (2023) 22 (12_Supplement): A084.

https://doi.org/10.1158/1535-7163.TARG-23-A084

Published: 01 December 2023

View articletitled, Abstract A084: Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRASG12C inhibitors that bind in the switch II pocket

Journal Articles

The Role of Protein Arginine Methyltransferases in Pathogenesis and Treatment of Digestive System Carcinoma

Bin Wang, Dong Ding, Xiaoan Zhang, Junxi Zhang, Huanhuan Zhang, Xinxin Liu, Hui Chang, Zhan Gao, Zengli Yu

Mol Cancer Ther (2023) 22 (8): 926–935.

https://doi.org/10.1158/1535-7163.MCT-22-0746

Published: 01 August 2023

View articletitled, The Role of Protein Arginine Methyltransferases in Pathogenesis and Treatment of Digestive System Carcinoma

Includes: Supplementary data

Journal Articles

Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

Mol Cancer Ther (2018) 17 (1_Supplement): B140.

https://doi.org/10.1158/1535-7163.TARG-17-B140

Published: 01 January 2018

View articletitled, Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

Journal Articles

Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells

Xinzhe Li, Bo Li, Zhenhong Ni, Peng Zhou, Bin Wang, Jintao He, Haojun Xiong, Fan Yang, Yaran Wu, Xilin Lyu, Yan Zhang, Yijun Zeng, Jiqin Lian, Fengtian He

Mol Cancer Ther (2017) 16 (9): 1806–1818.

https://doi.org/10.1158/1535-7163.MCT-16-0763

Published: 04 September 2017

View articletitled, Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells

Includes: Supplementary data

Journal Articles

B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation

Hao Liu, Christina Tekle, Yih-Wen Chen, Alexandr Kristian, Yuhua Zhao, Ming Zhou, Zixing Liu, Yan Ding, Bin Wang, Gunhild Mari Mælandsmo, Jahn Marthin Nesland, Oystein Fodstad, Ming Tan

Mol Cancer Ther (2011) 10 (6): 960–971.

https://doi.org/10.1158/1535-7163.MCT-11-0072

Published: 08 June 2011

View articletitled, B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation

Includes: Supplementary data

Journal Articles

Abstract B254: Extended target‐coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo

Michael J. Humphries, Ira von Carlowitz, Yvan Le Huerou, Nikole Randolph, Peter J. Mohr, Bin Wang, Michael A. Lyon, Indrani Gunawardana, Mark Chicarelli, Jim F. Blake, Michael L. Schrag, Shannon L. Winski, Eli Wallace

Mol Cancer Ther (2009) 8 (12_Supplement): B254.

https://doi.org/10.1158/1535-7163.TARG-09-B254

Published: 10 December 2009

View articletitled, Abstract B254: Extended target‐coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo

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Abstract A084: Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRAS^G12C inhibitors that bind in the switch II pocket

The Role of Protein Arginine Methyltransferases in Pathogenesis and Treatment of Digestive System Carcinoma

Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells

B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation

Abstract B254: Extended target‐coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo

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AACR Journals

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Abstract A084: Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRASG12C inhibitors that bind in the switch II pocket

The Role of Protein Arginine Methyltransferases in Pathogenesis and Treatment of Digestive System Carcinoma

Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells

B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation

Abstract B254: Extended target‐coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo

Email alerts

AACR Journals

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Abstract A084: Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRAS^G12C inhibitors that bind in the switch II pocket