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Journal Articles

PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo

Available to Purchase
Lihong Chen, Zachary P. Shultz, Marianna Sansone, Bin Fang, Xiang Liu, Mingxiang Teng, Ernst Schonbrunn, Justin M. Lopchuk, Jiandong Chen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther OF1–OF10.
https://doi.org/10.1158/1535-7163.MCT-24-1091
Published: 16 May 2025
View article titled, PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo
Open the PDF for PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo in another window
Includes: Supplementary data
Journal Articles

MIG6 Mediates Adaptive and Acquired Resistance to ALK/ROS1 Fusion Kinase Inhibition through EGFR Bypass Signaling

Open Access
Nan Chen, Logan C. Tyler, Anh T. Le, Eric A. Welsh, Bin Fang, Andrew Elliott, Kurtis D. Davies, Thomas Danhorn, Gregory J. Riely, Marc Ladanyi, Eric B. Haura, Robert C. Doebele
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (1): 92–105.
https://doi.org/10.1158/1535-7163.MCT-23-0218
Published: 03 January 2024
View article titled, MIG6 Mediates Adaptive and Acquired Resistance to ALK/ROS1 Fusion Kinase Inhibition through EGFR Bypass Signaling
Open the PDF for MIG6 Mediates Adaptive and Acquired Resistance to ALK/ROS1 Fusion Kinase Inhibition through EGFR Bypass Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract C054: PARP16 modulates MYC expression and susceptibility of Ewing’s Sarcoma cells to PARP1 inhibition

Free
Ou Deng, Xueli Li, Vinayak C Palve, Bin Fang, Damon R Reed, Uwe Rix
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C054.
https://doi.org/10.1158/1535-7163.TARG-23-C054
Published: 01 December 2023
View article titled, Abstract C054: PARP16 modulates MYC expression and susceptibility of Ewing’s Sarcoma cells to PARP1 inhibition
Journal Articles

Abstract P071: Phosphoproteomics identifies Mig6 as a key mediator of adaptive resistance to ALK/ROS1 oncogene inhibition

Free
Nan Chen, Anh T. Le, Eric A. Welsh, Bin Fang, Eric B. Haura, Robert C. Doebele
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P071.
https://doi.org/10.1158/1535-7163.TARG-21-P071
Published: 01 December 2021
View article titled, Abstract P071: Phosphoproteomics identifies Mig6 as a key mediator of adaptive resistance to ALK/ROS1 oncogene inhibition
Journal Articles

Abstract P018: Integrative proteomics of PARP1 protein complexes and post-translational modifications implicates DDR and AKT-mTOR signaling in mediating response or primary resistance of ovarian carcinoma cells to PARP1 inhibitors

Free
Ou Deng, Sweta Dash, Thales Nepomuceno, Bin Fang, Douglas Marchion, John Koomen, Alvaro N. Monteiro, Uwe Rix
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P018.
https://doi.org/10.1158/1535-7163.TARG-21-P018
Published: 01 December 2021
View article titled, Abstract P018: Integrative proteomics of PARP1 protein complexes and post-translational modifications implicates DDR and AKT-mTOR signaling in mediating response or primary resistance of ovarian carcinoma cells to PARP1 inhibitors
Journal Articles

Abstract B025: Integrative omics analysis decodes cross-talk between signaling pathways to understand the anti-cancer mechanism of TKIs in NSCLC

Free
Guolin Zhang, Karen Ross, Cuneyt Akcora, Katia Smirnova, Bin Fang, John M. Koomen, Eric B. Haura, Mark Grimes
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B025.
https://doi.org/10.1158/1535-7163.TARG-19-B025
Published: 01 December 2019
View article titled, Abstract B025: Integrative omics analysis decodes cross-talk between signaling pathways to understand the anti-cancer mechanism of TKIs in NSCLC
Journal Articles

Abstract B022: PARP1 complex composition as a predictor of response to PARP inhibitors in BRCA-linked ovarian carcinoma

Free
Ou Deng, Sweta Dash, Thales Nepomuceno, Ming D Han, Bin Fang, Doug Marchion, Alvaro N Monteiro, Uwe Rix
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B022.
https://doi.org/10.1158/1535-7163.TARG-19-B022
Published: 01 December 2019
View article titled, Abstract B022: PARP1 complex composition as a predictor of response to PARP inhibitors in BRCA-linked ovarian carcinoma
Journal Articles

Abstract B021: PARP16 is a novel target of talazoparib which contributes to synergy with adavosertib in SCLC

Free
Vinayak Palve, Clare Knezevic, Yunting Luo, Xueli Li, Slivia Novakova, Eric Welsh, Bin Fang, Fumi Kinose, Eric B Haura, Alvaro N Monteiro, John M Koomen, Harshani R Lawrence, Uwe Rix
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B021.
https://doi.org/10.1158/1535-7163.TARG-19-B021
Published: 01 December 2019
View article titled, Abstract B021: PARP16 is a novel target of talazoparib which contributes to synergy with adavosertib in SCLC
Journal Articles

Abstract C110: Cancer associated fibroblast-derived IGF-binding proteins augment osimertinib activity in EGFR-mutant NSCLC cells

Free
Lily L. Remsing Rix, Natalia J. Sumi, Annamarie T. Bryant, Xueli Li, Eric A. Welsh, Bin Fang, Brent M. Kuenzi, Scott J. Antonia, Andriy Marusyk, Christine M. Lovly, John M. Koomen, Eric B. Haura, Uwe Rix
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C110.
https://doi.org/10.1158/1535-7163.TARG-19-C110
Published: 01 December 2019
View article titled, Abstract C110: Cancer associated fibroblast-derived IGF-binding proteins augment osimertinib activity in EGFR-mutant NSCLC cells
Journal Articles

Target Identification in Small Cell Lung Cancer via Integrated Phenotypic Screening and Activity-Based Protein Profiling

Free
Jiannong Li, Bin Fang, Fumi Kinose, Yun Bai, Jae-Young Kim, Yian A. Chen, Uwe Rix, John M. Koomen, Eric B. Haura
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (2): 334–342.
https://doi.org/10.1158/1535-7163.MCT-15-0444
Published: 07 February 2016
View article titled, Target Identification in Small Cell Lung Cancer via Integrated Phenotypic Screening and Activity-Based Protein Profiling
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Includes: Supplementary data
Journal Articles

Abstract A61: Characterization of KRAS-driven survival signaling networks via phosphoproteomics in lung cancer.

Free
Jae-Young Kim, Eric A. Welsh, Bin Fang, Jiannong Li, Steven A. Eschrich, John Koomen, Eric B. Haura
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A61.
https://doi.org/10.1158/1535-7163.TARG-13-A61
Published: 01 November 2013
View article titled, Abstract A61: Characterization of KRAS-driven survival signaling networks via phosphoproteomics in lung cancer.
Journal Articles

The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2

Free
Rupashree Sen, Karthika Natarajan, Jasjeet Bhullar, Suneet Shukla, Hong-Bin Fang, Ling Cai, Zhe-Sheng Chen, Suresh V. Ambudkar, Maria R. Baer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (9): 2033–2044.
https://doi.org/10.1158/1535-7163.MCT-12-0302
Published: 06 September 2012
View article titled, The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2
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Journal Articles

Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer

Free
Tadas Vasaitis, Aashvini Belosay, Adam Schayowitz, Aakanksha Khandelwal, Pankaj Chopra, Lalji K. Gediya, Zhiyong Guo, Hong-Bin Fang, Vincent C.O. Njar, Angela M.H. Brodie
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (8): 2348–2357.
https://doi.org/10.1158/1535-7163.MCT-08-0230
Published: 21 August 2008
View article titled, Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
Open the PDF for Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer in another window