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Beverly A. Teicher
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Journal Articles

Abstract C045: Combinations of PI3K inhibitors with targeted oncology agents in multicellular spheroid models

Thomas S Dexheimer, Thomas Silvers, Nathan P Coussens, Rabih Said, Beverly A Teicher, James H Doroshow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C045.
https://doi.org/10.1158/1535-7163.TARG-23-C045
Published: 01 December 2023
View article titled, Abstract C045: Combinations of PI3K inhibitors with targeted oncology agents in multicellular spheroid models
Journal Articles

Abstract LB_A21: NCI60 HTS384: The next phase of the NCI60 screen

Beverly A Teicher, Mark W Kunkel, Joel Morris, Ronald C Taylor, Thomas S Dexheimer, Nathan P Coussens, James H Doroshow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): LB_A21.
https://doi.org/10.1158/1535-7163.TARG-23-LB_A21
Published: 01 December 2023
View article titled, Abstract LB_A21: NCI60 HTS384: The next phase of the NCI60 screen
Journal Articles

Abstract C095: The menin inhibitor VTP-50469 enhances the in vivo efficacy of established drugs against preclinical models of aggressive infant MLL-r acute lymphoblastic leukemia

Richard B Lock, Kathryn Evans, Sophia Gawan-Taylor, Ben Watts, Timothy Stearns, Eric J Earley, Emily L Jocoy, Carol J Bult, Beverly A Teicher, Gerard M McGeehan, Malcolm A Smith
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C095.
https://doi.org/10.1158/1535-7163.TARG-23-C095
Published: 01 December 2023
View article titled, Abstract C095: The menin inhibitor VTP-50469 enhances the <em>in vivo </em>efficacy of established drugs against preclinical models of aggressive infant MLL-r acute lymphoblastic leukemia
Journal Articles

Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource

Joel Morris, Mark W. Kunkel, Stephen L. White, Donn G. Wishka, Omar D. Lopez, Lori Bowles, Penny Sellers Brady, Patricia Ramsey, Julie Grams, Tiffany Rohrer, Karen Martin, Thomas S. Dexheimer, Nathan P. Coussens, David Evans, Prabhakar Risbood, Dmitriy Sonkin, John D. Williams, Eric C. Polley, Jerry M. Collins, James H. Doroshow, Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (11): 1270–1279.
https://doi.org/10.1158/1535-7163.MCT-23-0267
Published: 01 November 2023
View article titled, Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource
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Includes: Supplementary data
Journal Articles

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (11): 1625–1631.
https://doi.org/10.1158/1535-7163.MCT-22-0655
Published: 03 November 2022
View article titled, The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission
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Journal Articles

Trastuzumab Deruxtecan, Antibody–Drug Conjugate Targeting HER2, Is Effective in Pediatric Malignancies: A Report by the Pediatric Preclinical Testing Consortium

Pooja Hingorani, Wendong Zhang, Zhongting Zhang, Zhaohui Xu, Wei-Lien Wang, Michael E. Roth, Yifei Wang, Jonathan B. Gill, Douglas J. Harrison, Beverly A. Teicher, Stephen W. Erickson, Gregory Gatto, Edward A. Kolb, Malcolm A. Smith, Raushan T. Kurmasheva, Peter J. Houghton, Richard Gorlick
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (8): 1318–1325.
https://doi.org/10.1158/1535-7163.MCT-21-0758
Published: 02 August 2022
View article titled, Trastuzumab Deruxtecan, Antibody–Drug Conjugate Targeting HER2, Is Effective in Pediatric Malignancies: A Report by the Pediatric Preclinical Testing Consortium
Open the PDF for Trastuzumab Deruxtecan, Antibody–Drug Conjugate Targeting HER2, Is Effective in Pediatric Malignancies: A Report by the Pediatric Preclinical Testing Consortium in another window
Journal Articles

Abstract P222: Combinations of receptor tyrosine kinase inhibitors targeting the tumor and stromal cells of complex spheroids from the National Cancer Institute’s Patient-Derived Models Repository (PDMR; https://pdmr.cancer.gov/)

Thomas S. Dexheimer, Julie Laudeman, Thomas Silvers, Rene Delosh, Russell Reinhart, Chad Ogle, Eric Jones, Nathan P. Coussens, Beverly A. Teicher, Naoko Takebe, Alice Chen, James H. Doroshow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P222.
https://doi.org/10.1158/1535-7163.TARG-21-P222
Published: 01 December 2021
View article titled, Abstract P222: Combinations of receptor tyrosine kinase inhibitors targeting the tumor and stromal cells of complex spheroids from the National Cancer Institute’s Patient-Derived Models Repository (PDMR; https://pdmr.cancer.gov/)
Journal Articles

Twentieth Anniversary of Molecular Cancer Therapeutics: A Vision for the Future

Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (11): 2097.
https://doi.org/10.1158/1535-7163.MCT-21-0771
Published: 01 November 2021
View article titled, Twentieth Anniversary of <em>Molecular Cancer Therapeutics</em>: A Vision for the Future
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Journal Articles

F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd

Joel Morris, Donn G. Wishka, Omar D. Lopez, Vladimir Rudchenko, Guangfei Huang, Sierra N. Hoffman, Suzanne Borgel, Kyle Georgius, John Carter, Howard Stotler, Mark W. Kunkel, Jerry M. Collins, Melinda G. Hollingshead, Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2021) 20 (4): 625–631.
https://doi.org/10.1158/1535-7163.MCT-20-0738
Published: 01 April 2021
View article titled, F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd
Open the PDF for F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd in another window
Includes: Supplementary data
Journal Articles

Abstract C003: Initial testing of m276-PBD CD276 antibody-drug conjugate in preclinical models of pediatric cancers by the Pediatric Preclinical Testing Consortium (PPTC)

Raushan Kurmasheva, E. Anders Kolb, Malcolm A. Smith, Beverly A. Teicher, Stephen W. Erickson, John M. Maris, Yael P. Mosse, Kateryna Krytska, David Groff, Matthew Tang, Yifei Wang, Brad St. Croix, Richard Gorlick, Peter J. Houghton
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C003.
https://doi.org/10.1158/1535-7163.TARG-19-C003
Published: 01 December 2019
View article titled, Abstract C003: Initial testing of m276-PBD CD276 antibody-drug conjugate in preclinical models of pediatric cancers by the Pediatric Preclinical Testing Consortium (PPTC)
Journal Articles

Abstract C004: The CXCR4 inhibitor X4-136 enhances the in vivo efficacy of established drugs against preclinical models of aggressive pediatric acute lymphoblastic leukemia

Richard B Lock, Kathryn Evans, Connor D Jones, Narimanne El-Zein, Stephen W Erickson, Sarah Beaussant-Cohen, E. Lynne Kelley, Beverly A Teicher, Malcolm A Smith
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C004.
https://doi.org/10.1158/1535-7163.TARG-19-C004
Published: 01 December 2019
View article titled, Abstract C004: The CXCR4 inhibitor X4-136 enhances the <em>in vivo</em> efficacy of established drugs against preclinical models of aggressive pediatric acute lymphoblastic leukemia
Journal Articles

Abstract B013: Associations of epigenome-wide DNA methylation patterns with chemosensitivity and chemoresistance of small cell lung cancer cell lines

Julia Krushkal, Thomas Silvers, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, William C. Reinhold, Annamaria Rapisarda, David Evans, Yves Pommier, Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B013.
https://doi.org/10.1158/1535-7163.TARG-19-B013
Published: 01 December 2019
View article titled, Abstract B013: Associations of epigenome-wide DNA methylation patterns with chemosensitivity and chemoresistance of small cell lung cancer cell lines
Journal Articles

A Vision from the New Editor-in-Chief

Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (3): 497.
https://doi.org/10.1158/1535-7163.MCT-19-0094
Published: 01 March 2019
View article titled, A Vision from the New Editor-in-Chief
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Journal Articles

Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks

Aashish Soni, Fanghua Li, You Wang, Martha Grabos, Lisa Marie Krieger, Shipra Chaudhary, Mohammad Sharif Mortoga Hasan, Mansoor Ahmed, C. Norman Coleman, Beverly A. Teicher, Richard L. Piekarz, Dian Wang, George E. Iliakis
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (10): 2206–2216.
https://doi.org/10.1158/1535-7163.MCT-17-0836
Published: 01 October 2018
View article titled, Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks
Open the PDF for Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks in another window
Includes: Supplementary data
Journal Articles

Abstract A161: Comparison of EGFR inhibitor response of patient-derived NSCLC lines grown as monolayers, simple spheroids, and mixed cell complex spheroids

Gurmeet Kaur, John W. Connelly, Annamaria Rapisarda, James H. Doroshow, Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A161.
https://doi.org/10.1158/1535-7163.TARG-17-A161
Published: 01 January 2018
View article titled, Abstract A161: Comparison of EGFR inhibitor response of patient-derived NSCLC lines grown as monolayers, simple spheroids, and mixed cell complex spheroids
Journal Articles

Abstract A117: Modeling ATM loss of function via CRISPR-Cas9 as a predictive tool for therapeutic responses in cancer cells

Lara H. El Touny, John Connelly, Curtis Hose, Anne Monks, Dianne Newton, Luke Stockwin, Melinda Hollingshead, Ralph Parchment, James H. Doroshow, Beverly A. Teicher, Annamaria Rapisarda
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A117.
https://doi.org/10.1158/1535-7163.TARG-17-A117
Published: 01 January 2018
View article titled, Abstract A117: Modeling ATM loss of function via CRISPR-Cas9 as a predictive tool for therapeutic responses in cancer cells
Journal Articles

Abstract A116: Temozolomide-resistant MGMT/MSI double-negative cancer cells rely on ATR signaling and homologous recombination for DNA repair and survival

Lara H. El Touny, Erik Harris, Curtis Hose, John Connelly, Anne Monks, Dianne Newton, Luke Stockwin, Melinda Hollingshead, Ralph Parchment, James H. Doroshow, Beverly A. Teicher, Annamaria Rapisarda
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A116.
https://doi.org/10.1158/1535-7163.TARG-17-A116
Published: 01 January 2018
View article titled, Abstract A116: Temozolomide-resistant MGMT/MSI double-negative cancer cells rely on ATR signaling and homologous recombination for DNA repair and survival
Journal Articles

Abstract LB-B16: The AKR1C3-Activated Prodrug OBI-3424 Exerts Profound In Vivo Efficacy Against Preclinical Models of T-Cell Acute Lymphoblastic Leukemia (T-ALL); a Pediatric Preclinical Testing Consortium Study

Richard B. Lock, Kathryn Evans, Raymond Yung, Tara Pritchard, Beverly A. Teicher, JianXin Duan, Yuelong Guo, Stephen W. Erickson, Malcolm A. Smith
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): LB-B16.
https://doi.org/10.1158/1535-7163.TARG-17-LB-B16
Published: 01 January 2018
View article titled, Abstract LB-B16: The AKR1C3-Activated Prodrug OBI-3424 Exerts Profound <em>In Vivo</em> Efficacy Against Preclinical Models of T-Cell Acute Lymphoblastic Leukemia (T-ALL); a Pediatric Preclinical Testing Consortium Study
Journal Articles

Abstract LB-B15: Pediatric Preclinical Testing Consortium evaluation of the AZD1775 as a single agent and in combination with irinotecan

Peter J. Houghton, Raushan T. Kurmasheva, Richard Gorlick, E. Anders Kolb, Yael P. Mosse, Stephen W. Erickson, Yuelong Guo, Beverly A. Teicher, Malcolm A. Smith, John M. Maris
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): LB-B15.
https://doi.org/10.1158/1535-7163.TARG-17-LB-B15
Published: 01 January 2018
View article titled, Abstract LB-B15: Pediatric Preclinical Testing Consortium evaluation of the AZD1775 as a single agent and in combination with irinotecan
Journal Articles

Abstract LB-B12: Pediatric Preclinical Testing Consortium evaluation of 4’-thio-2’-deoxycytidine (TdCyd) and 5-aza-4’-thio-2’-deoxycytidine (Aza-TdCyd)

Beverly A. Teicher, Richard B. Lock, Jerry M. Collins, Richard Gorlick, E. Anders Kolb, Peter J. Houghton, Raushan T. Kurmasheva, Xiao-Nan Li, Stephen W. Erickson, Yuelong Guo, Kathryn Evans, Lin Qi, Malcolm A. Smith
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): LB-B12.
https://doi.org/10.1158/1535-7163.TARG-17-LB-B12
Published: 01 January 2018
View article titled, Abstract LB-B12: Pediatric Preclinical Testing Consortium evaluation of 4’-thio-2’-deoxycytidine (TdCyd) and 5-aza-4’-thio-2’-deoxycytidine (Aza-TdCyd)