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Ann-Lii Cheng
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Journal Articles

Abstract A080: A phase 1 study of single-agent pexidartinib in Asian patients with advanced solid tumors (NCT02734433)

Chia-Chi Lin, Jih-Hsiang Lee, Chih-Hung Hsu, Wei-Wu Chen, Yu-Hsin Yen, Chih-Hsin Yang, Ling Zhang, Shun-ichi Sasaki, Lillian Chiu, Ann-Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A080.
https://doi.org/10.1158/1535-7163.TARG-17-A080
Published: 01 January 2018
View article titled, Abstract A080: A phase 1 study of single-agent pexidartinib in Asian patients with advanced solid tumors (NCT02734433)
Journal Articles

Abstract C102: Combination of immune checkpoints DNA vaccines and radiation enhances melanoma control

Keng-Hsueh Lan, Ming-Feng Wei, Keng-Li Lan, Ann-Lii Cheng, Sung-Hsin Kuo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C102.
https://doi.org/10.1158/1535-7163.TARG-15-C102
Published: 01 December 2015
View article titled, Abstract C102: Combination of immune checkpoints DNA vaccines and radiation enhances melanoma control
Journal Articles

Synergistic Blockade of EGFR and HER2 by New-Generation EGFR Tyrosine Kinase Inhibitor Enhances Radiation Effect in Bladder Cancer Cells

Yu-Chieh Tsai, Pei-Yin Ho, Kai-Yuan Tzen, Tsung-Fan Tuan, Wei-Lin Liu, Ann-Lii Cheng, Yeong-Shiau Pu, Jason Chia-Hsien Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (3): 810–820.
https://doi.org/10.1158/1535-7163.MCT-13-0951
Published: 09 March 2015
View article titled, Synergistic Blockade of EGFR and HER2 by New-Generation EGFR Tyrosine Kinase Inhibitor Enhances Radiation Effect in Bladder Cancer Cells
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Includes: Supplementary data
Journal Articles

Abstract A285: Inhibition of histone deacetylase enhances radiosensitivity in hepatocellular carcinoma by inhibiting nuclear translocation of HDAC4 and DNA repair.

Wei-Lin Liu, Jason Chia-Hsien Cheng, Ming Gao, Ann-Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A285.
https://doi.org/10.1158/1535-7163.TARG-13-A285
Published: 01 November 2013
View article titled, Abstract A285: Inhibition of histone deacetylase enhances radiosensitivity in hepatocellular carcinoma by inhibiting nuclear translocation of HDAC4 and DNA repair.
Journal Articles

Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1–Mediated Inhibition of STAT3

Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Chun-Yu Liu, Ching-Huai Ko, Mai-Wei Lin, Pei-Jer Chen, Kuen-Feng Chen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (2): 452–463.
https://doi.org/10.1158/1535-7163.MCT-11-0412
Published: 08 February 2012
View article titled, Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1–Mediated Inhibition of STAT3
Open the PDF for Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1–Mediated Inhibition of STAT3 in another window
Journal Articles

Bortezomib Sensitizes HCC Cells to CS-1008, an Antihuman Death Receptor 5 Antibody, through the Inhibition of CIP2A

Kuen-Feng Chen, Hui-Chuan Yu, Chun-Yu Liu, Hui-Ju Chen, Yi-Ching Chen, Duen-Ren Hou, Pei-Jer Chen, Ann-Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (5): 892–901.
https://doi.org/10.1158/1535-7163.MCT-10-0794
Published: 08 May 2011
View article titled, Bortezomib Sensitizes HCC Cells to CS-1008, an Antihuman Death Receptor 5 Antibody, through the Inhibition of CIP2A
Open the PDF for Bortezomib Sensitizes HCC Cells to CS-1008, an Antihuman Death Receptor 5 Antibody, through the Inhibition of CIP2A in another window
Journal Articles

Abstract B81: AUY922, a heat shock protein 90 inhibitor, actively inhibits human gastric cancer cells via down regulation of growth factor receptors, and acts synergistically with relevant chemotherapeutic agents

Kun‐Huei Yeh, Chiu‐Hua Gao, Yu‐Lin Lin, Ann‐Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B81.
https://doi.org/10.1158/1535-7163.TARG-09-B81
Published: 10 December 2009
View article titled, Abstract B81: AUY922, a heat shock protein 90 inhibitor, actively inhibits human gastric cancer cells via down regulation of growth factor receptors, and acts synergistically with relevant chemotherapeutic agents
Journal Articles

Abstract B97: Dichloroacetate (DCA) enhances activities of sorafenib against hepatocellular carcinoma (HCC) via modulation of aberrant cellular metabolism of HCC cells

Ying‐Chun Shen, Hsiang‐Hsuan Fan, Da‐Liang Ou, Sheng‐Chieh Liao, Chiun Hsu, Shing‐Hwa Liu, Ann‐Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B97.
https://doi.org/10.1158/1535-7163.TARG-09-B97
Published: 10 December 2009
View article titled, Abstract B97: Dichloroacetate (DCA) enhances activities of sorafenib against hepatocellular carcinoma (HCC) via modulation of aberrant cellular metabolism of HCC cells
Journal Articles

Abstract A241: Searching for extracellular signal‐regulated kinase (ERK)‐independent molecular targets of sorafenib in hepatocellular carcinoma (HCC)

Hsiang‐Hsuan Fan, Sung‐Liang Yu, Da‐Liang Ou, Ying‐Chun Shen, Yi‐Ting Huang, Chiun Hsu, Ann‐Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A241.
https://doi.org/10.1158/1535-7163.TARG-09-A241
Published: 10 December 2009
View article titled, Abstract A241: Searching for extracellular signal‐regulated kinase (ERK)‐independent molecular targets of sorafenib in hepatocellular carcinoma (HCC)
Journal Articles

Abstract B226: Induction of growth arrest DNA damage‐inducible gene 45 beta (GADD45b) expression contributes to sorafenib‐induced apoptosis in hepatocellular carcinoma (HCC) cells

Da‐Liang Ou, Ying‐Chun Shen, Kuen‐Feng Chen, Ching‐Tzu Wang, Hsiang‐Hsuan Fan, Sung‐Liang Yu, Chiun Hsu, Ann‐Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B226.
https://doi.org/10.1158/1535-7163.TARG-09-B226
Published: 10 December 2009
View article titled, Abstract B226: Induction of growth arrest DNA damage‐inducible gene 45 beta (GADD45b) expression contributes to sorafenib‐induced apoptosis in hepatocellular carcinoma (HCC) cells
Journal Articles

Abstract A155: Activation of PI3K/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells

Kuen‐Feng Chen, Wen‐Chi Feng, Chih‐Hung Hsu, Pei‐Jer Chen, Ann‐Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A155.
https://doi.org/10.1158/1535-7163.TARG-09-A155
Published: 10 December 2009
View article titled, Abstract A155: Activation of PI3K/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells
Journal Articles

Validating Aurora B as a potential therapeutic target for human hepatocellular carcinoma

Zhong-Zhe Lin, Yung-Ming Jeng, Hey-Chi Hsu, Ann-Lii Cheng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B216.
Published: 01 November 2007
View article titled, Validating Aurora B as a potential therapeutic target for human hepatocellular carcinoma