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Anish Thomas
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Journal Articles

Abstract LB_A10: Efficacy of ATR inhibitor berzosertib plus topotecan or topotecan alone in patients with relapsed small cell lung cancer: A randomized clinical trial

Free
Nobuyuki Takahashi, Zhonglin Hao, Liza C Villaruz, Jun Zhang, Jimmy Ruiz, W. Jeffrey Petty, Hirva Mamdani, Jonathan W Riess, Jorge Nieva, Jose M Pachecho, Alexander D Fuld, Elaine Shum, Aman Chauhan, Samantha Nichols, Hirity Shimellis, Jessie McGlone, Linda Sciuto, Danielle Pinkiert, Chante Graham, Meenakshi Shelat, Robbie Kattappuram, Melissa Abel, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Ajit Kumar Sharma, Rajesh Kumar, Justin Malin, Christopher W Schultz, Shubhank Goyal, Christophe E Redon, Yves Pommier, Mirit I Aladjem, Steven D Gore, Seth M Steinberg, Rasa Vilimas, Parth Desai, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): LB_A10.
https://doi.org/10.1158/1535-7163.TARG-23-LB_A10
Published: 01 December 2023
View articletitled, Abstract LB_A10: Efficacy of ATR inhibitor berzosertib plus topotecan or topotecan alone in patients with relapsed small cell lung cancer: A randomized clinical trial
Journal Articles

Abstract B102: Predicting small cell lung cancer liver metastasis

Free
George Chrisafis, Nobuyuki Takahashi, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): B102.
https://doi.org/10.1158/1535-7163.TARG-23-B102
Published: 01 December 2023
View articletitled, Abstract B102: Predicting small cell lung cancer liver metastasis
Journal Articles

PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors

Available to Purchase
Anish Thomas, Shaun D. Fontaine, Morgan E. Diolaiti, Parth Desai, Rajesh Kumar, Nobuyuki Takahashi, Linda Sciuto, Samantha Nichols, Alan Ashworth, Felix Y. Feng, Gary W. Ashley, Minh Nguyen, Yves Pommier, Daniel V. Santi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (11): 1722–1728.
https://doi.org/10.1158/1535-7163.MCT-22-0217
Published: 03 November 2022
View articletitled, PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors
Open the PDF for PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II

Available to Purchase
Yilun Sun, Yang Zhang, Christopher W. Schultz, Yves Pommier, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (9): 1430–1438.
https://doi.org/10.1158/1535-7163.MCT-21-0891
Published: 06 September 2022
View articletitled, CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II
Open the PDF for CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II in another window
Includes: Supplementary data
Journal Articles

Abstract P047: A phase 1/2 trial of CBX-12, an alphalexTM peptide drug conjugate, in patients with advanced or metastatic refractory solid tumors

Free
Anthony Tolcher, Joseph Paul Eder, David Sommerhalder, Sophia Gayle, Paul Pearson, Deb Chapman, Arthur P. DeCillis, Anish Thomas, Funda Meric-Bernstam
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P047.
https://doi.org/10.1158/1535-7163.TARG-21-P047
Published: 01 December 2021
View articletitled, Abstract P047: A phase 1/2 trial of CBX-12, an alphalexTM peptide drug conjugate, in patients with advanced or metastatic refractory solid tumors
Journal Articles

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Open Access
Ukhyun Jo, Ilya S. Senatorov, Astrid Zimmermann, Liton Kumar Saha, Yasuhisa Murai, Se Hyun Kim, Vinodh N. Rajapakse, Fathi Elloumi, Nobuyuki Takahashi, Christopher W. Schultz, Anish Thomas, Frank T. Zenke, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (8): 1431–1441.
https://doi.org/10.1158/1535-7163.MCT-20-1026
Published: 01 August 2021
View articletitled, Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents
Open the PDF for Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents in another window
Journal Articles

Abstract A048: Whole exome sequencing of circulating free DNA reveals concordance with matched metastatic tumors and predicts survival in small cell lung cancer patients

Free
Vinodh N. Rajapakse, Nobuyuki Takahashi, Lorinc Pongor, Sehyun Kim, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): A048.
https://doi.org/10.1158/1535-7163.TARG-19-A048
Published: 01 December 2019
View articletitled, Abstract A048: Whole exome sequencing of circulating free DNA reveals concordance with matched metastatic tumors and predicts survival in small cell lung cancer patients
Journal Articles

Abstract A095: Phase Ib study of anetumab ravtansine in combination with pemetrexed and cisplatin in patients with mesothelin-expressing epithelial mesothelioma or nonsquamous non-small cell lung cancer

Free
Raffit Hassan, Ding Wang, John Wrangle, Anish Thomas, Angus Byars, Lianne Asschert, Rolando Atienza, Prabhu Rajagopalan, Annette Walter, Jun Zhang, Nenad Sarapa, Hedy Kindler
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A095.
https://doi.org/10.1158/1535-7163.TARG-17-A095
Published: 01 January 2018
View articletitled, Abstract A095: Phase Ib study of anetumab ravtansine in combination with pemetrexed and cisplatin in patients with mesothelin-expressing epithelial mesothelioma or nonsquamous non-small cell lung cancer
Journal Articles

Abstract CN05-03: Precision therapeutics with DNA-damaging agents

Free
Yves G. Pommier, William C. Reinhold, Junko Murai, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): CN05-03.
https://doi.org/10.1158/1535-7163.TARG-17-CN05-03
Published: 01 January 2018
View articletitled, Abstract CN05-03: Precision therapeutics with DNA-damaging agents