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Abstract B13: Synthetic vulnerabilities in MLL3 deficient pancreatic tumors

Sonal Gupta, Sammy Ferri-Borgogno, Mary R. Reisenauer, Anvita k. Gupta, Anirban Maitra

Mol Cancer Ther (2017) 16 (10_Supplement): B13.

DOI: https://doi.org/10.1158/1538-8514.SYNTHLETH-B13

Published: 02 October 2017

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Journal Articles

Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models

Chaoxin Hu, Tikva Dadon, Venugopal Chenna, Shinichi Yabuuchi, Rajat Bannerji, Robert Booher, Peter Strack, Nilofer Azad, Barry D. Nelkin, Anirban Maitra

Mol Cancer Ther (2015) 14 (7): 1532–1539.

DOI: https://doi.org/10.1158/1535-7163.MCT-15-0028

Published: 06 July 2015

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Includes: Supplementary data

Journal Articles

Abstract B263: Combined inhibition of cyclin-dependent kinases (Dinaciclib) and AKT (MK-2206) or ERK (SCH772984) dramatically blocks pancreatic tumor growth and metastases in patient-derived orthotopic xenograft models.

Chaoxin Hu, Tikva Dadon, Venugopal Chenna, Shin Yabuuchi, Rajat Bannerji, Robert Booher, Peter Strack, Ahmed Samatar, Nilofer Azad, Barry D. Nelkin, Anirban Maitra

Mol Cancer Ther (2013) 12 (11_Supplement): B263.

DOI: https://doi.org/10.1158/1535-7163.TARG-13-B263

Published: 01 November 2013

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Journal Articles

The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models

Masamichi Mizuma, Zeshaan A. Rasheed, Shinichi Yabuuchi, Noriyuki Omura, Nathaniel R. Campbell, Roeland F. de Wilde, Elizabeth De Oliveira, Qing Zhang, Oscar Puig, William Matsui, Manuel Hidalgo, Anirban Maitra, N.V. Rajeshkumar

Mol Cancer Ther (2012) 11 (9): 1999–2009.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0017

Published: 06 September 2012

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Includes: Supplementary data

Journal Articles

A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists

Venugopal Chenna, Chaoxin Hu, Dipankar Pramanik, Blake T. Aftab, Collins Karikari, Nathaniel R. Campbell, Seung-Mo Hong, Ming Zhao, Michelle A. Rudek, Saeed R. Khan, Charles M. Rudin, Anirban Maitra

Mol Cancer Ther (2012) 11 (1): 165–173.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0341

Published: 09 January 2012

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Includes: Supplementary data

Journal Articles

Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth

Melissa L. Fishel, Yanlin Jiang, N.V. Rajeshkumar, Glenda Scandura, Anthony L. Sinn, Ying He, Changyu Shen, David R. Jones, Karen E. Pollok, Mircea Ivan, Anirban Maitra, Mark R. Kelley

Mol Cancer Ther (2011) 10 (9): 1698–1708.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0107

Published: 07 September 2011

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Includes: Supplementary data

Journal Articles

Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice

Dipankar Pramanik, Nathaniel R. Campbell, Collins Karikari, Raghu Chivukula, Oliver A. Kent, Joshua T. Mendell, Anirban Maitra

Mol Cancer Ther (2011) 10 (8): 1470–1480.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0152

Published: 08 August 2011

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Includes: Supplementary data

Journal Articles

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

Maria C. Villarroel, N.V. Rajeshkumar, Ignacio Garrido-Laguna, Ana De Jesus-Acosta, Siân Jones, Anirban Maitra, Ralph H. Hruban, James R. Eshleman, Alison Klein, Daniel Laheru, Ross Donehower, Manuel Hidalgo

Mol Cancer Ther (2011) 10 (1): 3–8.

DOI: https://doi.org/10.1158/1535-7163.MCT-10-0893

Published: 10 January 2011

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Journal Articles

Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer

Savita Bisht, Masamichi Mizuma, Georg Feldmann, Niki A. Ottenhof, Seung-Mo Hong, Dipankar Pramanik, Venugopal Chenna, Collins Karikari, Rajni Sharma, Michael G. Goggins, Michelle A. Rudek, Rajani Ravi, Amarnath Maitra, Anirban Maitra

Mol Cancer Ther (2010) 9 (8): 2255–2264.

DOI: https://doi.org/10.1158/1535-7163.MCT-10-0172

Published: 09 August 2010

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Includes: Supplementary data

Journal Articles

Abstract A243: SCH727965, a novel potent cyclin dependent kinase inhibitor, inhibits pancreatic tumor growth and Ras‐mediated tumorigenic signaling

Anjali Mishra, Georg Feldmann, Ignacio Garrido‐Laguna, Tikva Dadon, Christopher J. Strock, Rajat Bannerji, Manuel Hidalgo, Anirban Maitra, Barry D. Nelkin

Mol Cancer Ther (2009) 8 (12_Supplement): A243.

DOI: https://doi.org/10.1158/1535-7163.TARG-09-A243

Published: 10 December 2009

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Journal Articles

Abstract A251: MK‐1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions in pancreatic tumor xenografts

N.V. Rajeshkumar, Elizabeth De Oliveira, Niki A. Ottenhof, Ignacio Garrido‐Laguna, Maria C. Villarroel, James Watters, Tim Demuth, David Brooks, Shinji Mizuarai, Hiroshi Hirai, Anirban Maitra, Manuel Hidalgo

Mol Cancer Ther (2009) 8 (12_Supplement): A251.

DOI: https://doi.org/10.1158/1535-7163.TARG-09-A251

Published: 10 December 2009

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Journal Articles

Abstract C246: nab®‐paclitaxel targets tumor stroma and results, combined with gemcitabine, in high efficacy against pancreatic cancer models

Anirban Maitra, N.V. Rajeshkumar, Michelle Rudek, Ignacio Garrido‐Laguna, Daniel Laheru, Jose Iglesias, Neil Desai, Daniel D. Von Hoff, Manuel Hidalgo

Mol Cancer Ther (2009) 8 (12_Supplement): C246.

DOI: https://doi.org/10.1158/1535-7163.TARG-09-C246

Published: 10 December 2009

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Journal Articles

A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development

Antonio Jimeno, Georg Feldmann, Ana Suárez-Gauthier, Zeshaan Rasheed, Anna Solomon, Gang-Ming Zou, Belen Rubio-Viqueira, Elena García-García, Fernando López-Ríos, William Matsui, Anirban Maitra, Manuel Hidalgo

Mol Cancer Ther (2009) 8 (2): 310–314.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0924

Published: 11 February 2009

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Journal Articles

In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities

Savita Bisht, Georg Feldmann, Jan-Bart M. Koorstra, Michael Mullendore, Hector Alvarez, Collins Karikari, Michelle A. Rudek, Carlton K. Lee, Amarnath Maitra, Anirban Maitra

Mol Cancer Ther (2008) 7 (12): 3878–3888.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0476

Published: 15 December 2008

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Journal Articles

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

Georg Feldmann, Volker Fendrich, Karen McGovern, Djahida Bedja, Savita Bisht, Hector Alvarez, Jan-Bart M. Koorstra, Nils Habbe, Collins Karikari, Michael Mullendore, Kathleen L. Gabrielson, Rajni Sharma, William Matsui, Anirban Maitra

Mol Cancer Ther (2008) 7 (9): 2725–2735.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0573

Published: 11 September 2008

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Journal Articles

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

Gang-Ming Zou, Anirban Maitra

Mol Cancer Ther (2008) 7 (7): 2012–2021.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0113

Published: 21 July 2008

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Journal Articles

Coordinated over-expression of genes in the EGFR pathway predicts sensitivity to EGFR inhibition in pancreatic cancer

Antonio Jimeno, Aik Choon Tan, Jordy Coffa, N V Rajeshkumar, Peter Kulesza, Belen Rubio-Viqueira, Jenna Wheelhouse, Begona Diosdadp, Wells Messersmith, Christine Iacobuzio-Donahue, Anirban Maitra, Marileila Varela-Garcia, Fred Hirsch, Manuel Hidalgo

Mol Cancer Ther (2007) 6 (11_Supplement): B108.

Published: 01 November 2007

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Journal Articles

CDK5 inhibition suppresses pancreatic cancer tumorigenesis and metastasis

Georg Feldmann, Christopher Strock, Anjali Mishra, Douglas Ball, Anirban Maitra, Barry Nelkin

Mol Cancer Ther (2007) 6 (11_Supplement): C68.

Published: 01 November 2007

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Journal Articles

Identification of cancer specific high affinity targeting ligands by screening One-bead-one-compound and small molecule combinatorial libraries

Pappanaicken Kumaresan, Vaishali Ahir, Ruiwu Liu, Yan Wang, Anirban Maitra, kit Lam

Mol Cancer Ther (2007) 6 (11_Supplement): A220.

Published: 01 November 2007

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Journal Articles

Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer

Antonio Jimeno, Belen Rubio-Viqueira, Maria L. Amador, Victor Grunwald, Anirban Maitra, Christine Iacobuzio-Donahue, Manuel Hidalgo

Mol Cancer Ther (2007) 6 (3): 1079–1088.

DOI: https://doi.org/10.1158/1535-7163.MCT-06-0448

Published: 15 March 2007

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NARROW

Abstract B13: Synthetic vulnerabilities in MLL3 deficient pancreatic tumors

Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models

Abstract B263: Combined inhibition of cyclin-dependent kinases (Dinaciclib) and AKT (MK-2206) or ERK (SCH772984) dramatically blocks pancreatic tumor growth and metastases in patient-derived orthotopic xenograft models.

The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models

A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists

Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth

Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer

Abstract A243: SCH727965, a novel potent cyclin dependent kinase inhibitor, inhibits pancreatic tumor growth and Ras‐mediated tumorigenic signaling

Abstract A251: MK‐1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions in pancreatic tumor xenografts

Abstract C246: nab®‐paclitaxel targets tumor stroma and results, combined with gemcitabine, in high efficacy against pancreatic cancer models

A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development

In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

Coordinated over-expression of genes in the EGFR pathway predicts sensitivity to EGFR inhibition in pancreatic cancer

CDK5 inhibition suppresses pancreatic cancer tumorigenesis and metastasis

Identification of cancer specific high affinity targeting ligands by screening One-bead-one-compound and small molecule combinatorial libraries

Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer

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