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Journal Articles

Abstract A111: Impact of KRAS mutations and co-mutations on clinical outcomes in Pancreatic Ductal Adenocarcinoma

Free
Abdelrahman Yousef, Mahmoud Yousef, Saikat Chowdhury, Kawther Abdilleh, Mark Knafl, Paul Edelkamp, Kristin Alfaro-Munoz, Ray Chacko, Jennifer Peterson, Brandon Smaglo, Robert Wolff, Shubham Pant, Michael Lee, Jason Willis, Michael Overman, Sudheer Doss, Lynn Matrisian, Mark Hurd, Rebecca Snyder, Matthew Harold Katz, Huamin Wang, Anirban Maitra, John Paul Shen, Dan Zhao
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): A111.
https://doi.org/10.1158/1535-7163.TARG-23-A111
Published: 01 December 2023
View articletitled, Abstract A111: Impact of KRAS mutations and co-mutations on clinical outcomes in Pancreatic Ductal Adenocarcinoma
Journal Articles

Abstract B13: Synthetic vulnerabilities in MLL3 deficient pancreatic tumors

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Sonal Gupta, Sammy Ferri-Borgogno, Mary R. Reisenauer, Anvita k. Gupta, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (10_Supplement): B13.
https://doi.org/10.1158/1538-8514.SYNTHLETH-B13
Published: 02 October 2017
View articletitled, Abstract B13: Synthetic vulnerabilities in MLL3 deficient pancreatic tumors
Journal Articles

Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models

Free
Chaoxin Hu, Tikva Dadon, Venugopal Chenna, Shinichi Yabuuchi, Rajat Bannerji, Robert Booher, Peter Strack, Nilofer Azad, Barry D. Nelkin, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (7): 1532–1539.
https://doi.org/10.1158/1535-7163.MCT-15-0028
Published: 06 July 2015
View articletitled, Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models
Open the PDF for Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models in another window
Includes: Supplementary data
Journal Articles

Abstract B263: Combined inhibition of cyclin-dependent kinases (Dinaciclib) and AKT (MK-2206) or ERK (SCH772984) dramatically blocks pancreatic tumor growth and metastases in patient-derived orthotopic xenograft models.

Free
Chaoxin Hu, Tikva Dadon, Venugopal Chenna, Shin Yabuuchi, Rajat Bannerji, Robert Booher, Peter Strack, Ahmed Samatar, Nilofer Azad, Barry D. Nelkin, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B263.
https://doi.org/10.1158/1535-7163.TARG-13-B263
Published: 01 November 2013
View articletitled, Abstract B263: Combined inhibition of cyclin-dependent kinases (Dinaciclib) and AKT (MK-2206) or ERK (SCH772984) dramatically blocks pancreatic tumor growth and metastases in patient-derived orthotopic xenograft models.
Journal Articles

The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models

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Masamichi Mizuma, Zeshaan A. Rasheed, Shinichi Yabuuchi, Noriyuki Omura, Nathaniel R. Campbell, Roeland F. de Wilde, Elizabeth De Oliveira, Qing Zhang, Oscar Puig, William Matsui, Manuel Hidalgo, Anirban Maitra, N.V. Rajeshkumar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (9): 1999–2009.
https://doi.org/10.1158/1535-7163.MCT-12-0017
Published: 06 September 2012
View articletitled, The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models
Open the PDF for The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models in another window
Includes: Supplementary data
Journal Articles

A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists

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Venugopal Chenna, Chaoxin Hu, Dipankar Pramanik, Blake T. Aftab, Collins Karikari, Nathaniel R. Campbell, Seung-Mo Hong, Ming Zhao, Michelle A. Rudek, Saeed R. Khan, Charles M. Rudin, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (1): 165–173.
https://doi.org/10.1158/1535-7163.MCT-11-0341
Published: 09 January 2012
View articletitled, A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists
Open the PDF for A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists in another window
Includes: Supplementary data
Journal Articles

Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth

Free
Melissa L. Fishel, Yanlin Jiang, N.V. Rajeshkumar, Glenda Scandura, Anthony L. Sinn, Ying He, Changyu Shen, David R. Jones, Karen E. Pollok, Mircea Ivan, Anirban Maitra, Mark R. Kelley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (9): 1698–1708.
https://doi.org/10.1158/1535-7163.MCT-11-0107
Published: 07 September 2011
View articletitled, Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth
Open the PDF for Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice

Free
Dipankar Pramanik, Nathaniel R. Campbell, Collins Karikari, Raghu Chivukula, Oliver A. Kent, Joshua T. Mendell, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (8): 1470–1480.
https://doi.org/10.1158/1535-7163.MCT-11-0152
Published: 08 August 2011
View articletitled, Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice
Open the PDF for Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice in another window
Includes: Supplementary data
Journal Articles

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

Free
Maria C. Villarroel, N.V. Rajeshkumar, Ignacio Garrido-Laguna, Ana De Jesus-Acosta, Siân Jones, Anirban Maitra, Ralph H. Hruban, James R. Eshleman, Alison Klein, Daniel Laheru, Ross Donehower, Manuel Hidalgo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (1): 3–8.
https://doi.org/10.1158/1535-7163.MCT-10-0893
Published: 10 January 2011
View articletitled, Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer
Open the PDF for Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer in another window
Journal Articles

Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer

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Savita Bisht, Masamichi Mizuma, Georg Feldmann, Niki A. Ottenhof, Seung-Mo Hong, Dipankar Pramanik, Venugopal Chenna, Collins Karikari, Rajni Sharma, Michael G. Goggins, Michelle A. Rudek, Rajani Ravi, Amarnath Maitra, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (8): 2255–2264.
https://doi.org/10.1158/1535-7163.MCT-10-0172
Published: 09 August 2010
View articletitled, Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer
Open the PDF for Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C246: nab®‐paclitaxel targets tumor stroma and results, combined with gemcitabine, in high efficacy against pancreatic cancer models

Free
Anirban Maitra, N.V. Rajeshkumar, Michelle Rudek, Ignacio Garrido‐Laguna, Daniel Laheru, Jose Iglesias, Neil Desai, Daniel D. Von Hoff, Manuel Hidalgo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C246.
https://doi.org/10.1158/1535-7163.TARG-09-C246
Published: 10 December 2009
View articletitled, Abstract C246: nab®‐paclitaxel targets tumor stroma and results, combined with gemcitabine, in high efficacy against pancreatic cancer models
Journal Articles

Abstract A243: SCH727965, a novel potent cyclin dependent kinase inhibitor, inhibits pancreatic tumor growth and Ras‐mediated tumorigenic signaling

Free
Anjali Mishra, Georg Feldmann, Ignacio Garrido‐Laguna, Tikva Dadon, Christopher J. Strock, Rajat Bannerji, Manuel Hidalgo, Anirban Maitra, Barry D. Nelkin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A243.
https://doi.org/10.1158/1535-7163.TARG-09-A243
Published: 10 December 2009
View articletitled, Abstract A243: SCH727965, a novel potent cyclin dependent kinase inhibitor, inhibits pancreatic tumor growth and Ras‐mediated tumorigenic signaling
Journal Articles

Abstract A251: MK‐1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions in pancreatic tumor xenografts

Free
N.V. Rajeshkumar, Elizabeth De Oliveira, Niki A. Ottenhof, Ignacio Garrido‐Laguna, Maria C. Villarroel, James Watters, Tim Demuth, David Brooks, Shinji Mizuarai, Hiroshi Hirai, Anirban Maitra, Manuel Hidalgo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A251.
https://doi.org/10.1158/1535-7163.TARG-09-A251
Published: 10 December 2009
View articletitled, Abstract A251: MK‐1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions in pancreatic tumor xenografts
Journal Articles

A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development

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Antonio Jimeno, Georg Feldmann, Ana Suárez-Gauthier, Zeshaan Rasheed, Anna Solomon, Gang-Ming Zou, Belen Rubio-Viqueira, Elena García-García, Fernando López-Ríos, William Matsui, Anirban Maitra, Manuel Hidalgo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (2): 310–314.
https://doi.org/10.1158/1535-7163.MCT-08-0924
Published: 11 February 2009
View articletitled, A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
Open the PDF for A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development in another window
Journal Articles

In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities

Free
Savita Bisht, Georg Feldmann, Jan-Bart M. Koorstra, Michael Mullendore, Hector Alvarez, Collins Karikari, Michelle A. Rudek, Carlton K. Lee, Amarnath Maitra, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (12): 3878–3888.
https://doi.org/10.1158/1535-7163.MCT-08-0476
Published: 15 December 2008
View articletitled, In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities
Open the PDF for In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities in another window
Journal Articles

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

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Georg Feldmann, Volker Fendrich, Karen McGovern, Djahida Bedja, Savita Bisht, Hector Alvarez, Jan-Bart M. Koorstra, Nils Habbe, Collins Karikari, Michael Mullendore, Kathleen L. Gabrielson, Rajni Sharma, William Matsui, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2725–2735.
https://doi.org/10.1158/1535-7163.MCT-08-0573
Published: 11 September 2008
View articletitled, An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
Open the PDF for An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer in another window
Journal Articles

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

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Gang-Ming Zou, Anirban Maitra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (7): 2012–2021.
https://doi.org/10.1158/1535-7163.MCT-08-0113
Published: 21 July 2008
View articletitled, Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration
Open the PDF for Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration in another window
Journal Articles

CDK5 inhibition suppresses pancreatic cancer tumorigenesis and metastasis

Free
Georg Feldmann, Christopher Strock, Anjali Mishra, Douglas Ball, Anirban Maitra, Barry Nelkin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C68.
Published: 01 November 2007
View articletitled, CDK5 inhibition suppresses pancreatic cancer tumorigenesis and metastasis
Journal Articles

Coordinated over-expression of genes in the EGFR pathway predicts sensitivity to EGFR inhibition in pancreatic cancer

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Antonio Jimeno, Aik Choon Tan, Jordy Coffa, N V Rajeshkumar, Peter Kulesza, Belen Rubio-Viqueira, Jenna Wheelhouse, Begona Diosdadp, Wells Messersmith, Christine Iacobuzio-Donahue, Anirban Maitra, Marileila Varela-Garcia, Fred Hirsch, Manuel Hidalgo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B108.
Published: 01 November 2007
View articletitled, Coordinated over-expression of genes in the EGFR pathway predicts sensitivity to EGFR inhibition in pancreatic cancer
Journal Articles

Identification of cancer specific high affinity targeting ligands by screening One-bead-one-compound and small molecule combinatorial libraries

Free
Pappanaicken Kumaresan, Vaishali Ahir, Ruiwu Liu, Yan Wang, Anirban Maitra, kit Lam
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A220.
Published: 01 November 2007
View articletitled, Identification of cancer specific high affinity targeting ligands by screening One-bead-one-compound and small molecule combinatorial libraries