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Angela Coxon
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Journal Articles

Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule

Elizabeth Pham, Matthias Friedrich, Famke Aeffner, Michael Lutteropp, Natalie F. Mariano, Petra Deegen, Christoph Dahlhoff, Franziska Vogel, Claudia Bluemel, John M. Harrold, Christian Brandl, Natalia Grinberg, Benno Rattel, Angela Coxon, Julie M. Bailis
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (10): 1977–1987.
https://doi.org/10.1158/1535-7163.MCT-21-0236
Published: 01 October 2021
View article titled, Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
Open the PDF for Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule in another window
Includes: Supplementary data
Journal Articles

Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia

Bettina Brauchle, Rebecca L. Goldstein, Christine M. Karbowski, Anja Henn, Chi-Ming Li, Veit L. Bücklein, Christina Krupka, Michael C. Boyle, Priya Koppikar, Sascha Haubner, Joachim Wahl, Christoph Dahlhoff, Tobias Raum, Matthew J. Rardin, Christine Sastri, Dan A. Rock, Michael von Bergwelt-Baildon, Brendon Frank, Klaus H. Metzeler, Ryan Case, Matthias Friedrich, Mercedesz Balazs, Karsten Spiekermann, Angela Coxon, Marion Subklewe, Tara Arvedson
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (9): 1875–1888.
https://doi.org/10.1158/1535-7163.MCT-19-1093
Published: 02 September 2020
View article titled, Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia
Open the PDF for Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma

May Elbanna, Ashley R. Orillion, Nur P. Damayanti, Remi Adelaiye-Ogala, Li Shen, Kiersten Marie Miles, Sreenivasulu Chintala, Eric Ciamporcero, Swathi Ramakrishnan, Sheng-yu Ku, Karen Rex, Sean Caenepeel, Angela Coxon, Roberto Pili
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (1): 147–156.
https://doi.org/10.1158/1535-7163.MCT-18-1202
Published: 03 January 2020
View article titled, Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma
Open the PDF for Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes

Marc Payton, Hung-Kam Cheung, Maria Stefania S. Ninniri, Christian Marinaccio, William C. Wayne, Kelly Hanestad, John D. Crispino, Gloria Juan, Angela Coxon
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (12): 2575–2585.
https://doi.org/10.1158/1535-7163.MCT-18-0186
Published: 03 December 2018
View article titled, Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes
Open the PDF for Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes in another window
Includes: Supplementary data
Journal Articles

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Paul E. Hughes, Karen Rex, Sean Caenepeel, Yajing Yang, Yihong Zhang, Martin A. Broome, Hue T. Kha, Teresa L. Burgess, Benny Amore, Paula J. Kaplan-Lefko, Jodi Moriguchi, Jonathan Werner, Michael A. Damore, Daniel Baker, Deborah M. Choquette, Jean-Christophe Harmange, Robert Radinsky, Richard Kendall, Isabelle Dussault, Angela Coxon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (7): 1568–1579.
https://doi.org/10.1158/1535-7163.MCT-15-0871
Published: 05 July 2016
View article titled, <em>In Vitro</em> and <em>In Vivo</em> Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models
Open the PDF for <em>In Vitro</em> and <em>In Vivo</em> Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models in another window
Includes: Supplementary data
Journal Articles

Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma

Zhiqiang Du, Sean Caenepeel, Yuqing Shen, Karen Rex, Yanni Zhang, Ying He, En-Tzu Tang, Ouhong Wang, Wenge Zhong, Hui Zhou, Jacqueline Huang, Eric Huang, Liaoyuan Hu, Angela Coxon, Mingqiang Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (6): 1227–1237.
https://doi.org/10.1158/1535-7163.MCT-15-0745
Published: 02 June 2016
View article titled, Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma
Open the PDF for Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Jude Canon, Tao Osgood, Steven H. Olson, Anne Y. Saiki, Rebecca Robertson, Dongyin Yu, John Eksterowicz, Qiuping Ye, Lixia Jin, Ada Chen, Jing Zhou, David Cordover, Stephen Kaufman, Richard Kendall, Jonathan D. Oliner, Angela Coxon, Robert Radinsky
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (3): 649–658.
https://doi.org/10.1158/1535-7163.MCT-14-0710
Published: 09 March 2015
View article titled, The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents
Open the PDF for The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents in another window
Includes: Supplementary data
Journal Articles

Abstract A204: A cellular model of acquired resistance to rilotumumab (AMG 102) in glioblastoma.

Fabiola Cecchi, Karen Rex, Joanna Schmidt, Daniel Baker, Michael A. Damore, Angela Coxon, Teresa L. Burgess, Donald P. Bottaro
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A204.
https://doi.org/10.1158/1535-7163.TARG-11-A204
Published: 12 November 2011
View article titled, Abstract A204: A cellular model of acquired resistance to rilotumumab (AMG 102) in glioblastoma.
Journal Articles

Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Angela Coxon, James Bready, Hosung Min, Stephen Kaufman, Juan Leal, Dongyin Yu, Tani Ann Lee, Ji-Rong Sun, Juan Estrada, Brad Bolon, James McCabe, Ling Wang, Karen Rex, Sean Caenepeel, Paul Hughes, David Cordover, Haejin Kim, Seog Joon Han, Mark L. Michaels, Eric Hsu, Grant Shimamoto, Russell Cattley, Eunju Hurh, Linh Nguyen, Shao Xiong Wang, Anthony Ndifor, Isaac J. Hayward, Beverly L. Falcón, Donald M. McDonald, Luke Li, Tom Boone, Richard Kendall, Robert Radinsky, Jonathan D. Oliner
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (10): 2641–2651.
https://doi.org/10.1158/1535-7163.MCT-10-0213
Published: 10 October 2010
View article titled, Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody
Open the PDF for Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody in another window
Includes: Supplementary data
Journal Articles

Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor

Teresa L. Burgess, Jan Sun, Susanne Meyer, Trace S. Tsuruda, Jilin Sun, Gary Elliott, Qing Chen, Mitsuru Haniu, Will F. Barron, Todd Juan, Ke Zhang, Angela Coxon, Richard L. Kendall
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (2): 400–409.
https://doi.org/10.1158/1535-7163.MCT-09-0824
Published: 09 February 2010
View article titled, Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor
Open the PDF for Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor in another window
Includes: Supplementary data
Journal Articles

Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma

Chong-Feng Gao, Qian Xie, Yu-Wen Zhang, Yanli Su, Ping Zhao, Brian Cao, Kyle Furge, Jan Sun, Karen Rex, Tao Osgood, Angela Coxon, Teresa L. Burgess, George F. Vande Woude
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2803–2810.
https://doi.org/10.1158/1535-7163.MCT-09-0125
Published: 12 October 2009
View article titled, Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma
Open the PDF for Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma in another window
Journal Articles

Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met–dependent tumors in animal models

Angela Coxon, Karen Rex, Susanne Meyer, Jianling Sun, Jilin Sun, Qing Chen, Robert Radinsky, Richard Kendall, Teresa L. Burgess
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (5): 1119–1125.
https://doi.org/10.1158/1535-7163.MCT-08-1032
Published: 13 May 2009
View article titled, Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met–dependent tumors in animal models
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Journal Articles

Identification and characterization of a novel RON/c-Met small molecule inhibitor

Yihong Zhang, Paula Kaplan-Lefko, Karen Rex, Yajing Yang, Jodi Moriguchi, Tao Osgood, Bethany Mattson, Angela Coxon, Teresa Burgess, Isabelle Dussault
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A223.
Published: 01 November 2007
View article titled, Identification and characterization of a novel RON/c-Met small molecule inhibitor