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Andrew G. Polson
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Journal Articles

Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

Peiyin Wang, Liping L. Sun, Robyn Clark, Maria Hristopoulos, Cecilia P.C. Chiu, Michael Dillon, WeiYu Lin, Amy A. Lo, Sreedevi Chalsani, Meghna Das Thakur, Kristin M. Zimmerman Savill, Lionel Rougé, Patrick Lupardus, Robert Piskol, Bushra Husain, Diego Ellerman, Vittal Shivva, Steven R. Leong, Meric Ovacik, Klara Totpal, Yan Wu, Christoph Spiess, Genee Lee, Douglas D. Leipold, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 974–985.
https://doi.org/10.1158/1535-7163.MCT-21-0599
Published: 01 June 2022
View article titled, Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Calicheamicin Antibody–Drug Conjugates with Improved Properties

Breanna S. Vollmar, Chris Frantz, Melissa M. Schutten, Fiona Zhong, Geoffrey del Rosario, Mary Ann T. Go, Shang-Fan Yu, Douglas D. Leipold, Amrita V. Kamath, Carl Ng, Keyang Xu, Josefa dela Cruz-Chuh, Katherine R. Kozak, Jinhua Chen, Zijin Xu, John Wai, Pragya Adhikari, Hans K. Erickson, Peter S. Dragovich, Andrew G. Polson, Thomas H. Pillow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (6): 1112–1120.
https://doi.org/10.1158/1535-7163.MCT-20-0035
Published: 01 June 2021
View article titled, Calicheamicin Antibody–Drug Conjugates with Improved Properties
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Includes: Supplementary data
Journal Articles

An Anti–CD22-seco-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models

Shang-Fan Yu, Donna W. Lee, Bing Zheng, Geoffrey del Rosario, Douglas Leipold, Helen Booler, Fiona Zhong, Montserrat Carrasco-Triguero, Kyu Hong, Peter Yan, Rebecca K. Rowntree, Melissa M. Schutten, Thomas Pillow, Jack D. Sadowsky, Peter S. Dragovich, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (2): 340–346.
https://doi.org/10.1158/1535-7163.MCT-20-0046
Published: 05 February 2021
View article titled, An Anti–CD22-<em>seco</em>-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models
Open the PDF for An Anti–CD22-<em>seco</em>-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models in another window
Includes: Supplementary data
Journal Articles

Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates

Donglu Zhang, Shang-Fan Yu, S. Cyrus Khojasteh, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Katherine R. Kozak, Keyang Xu, Andrew G. Polson, Peter S. Dragovich, Cornelis E.C.A. Hop
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (3): 677–685.
https://doi.org/10.1158/1535-7163.MCT-17-0697
Published: 28 February 2018
View article titled, Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates
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Includes: Supplementary data
Journal Articles

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

Thomas H. Pillow, Melissa Schutten, Shang-Fan Yu, Rachana Ohri, Jack Sadowsky, Kirsten Achilles Poon, Willy Solis, Fiona Zhong, Geoffrey Del Rosario, Mary Ann T. Go, Jeffrey Lau, Sharon Yee, Jintang He, Luna Liu, Carl Ng, Keyang Xu, Douglas D. Leipold, Amrita V. Kamath, Donglu Zhang, Luke Masterson, Stephen J. Gregson, Philip W. Howard, Fan Fang, Jinhua Chen, Janet Gunzner-Toste, Katherine K. Kozak, Susan Spencer, Paul Polakis, Andrew G. Polson, John A. Flygare, Jagath R. Junutula
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (5): 871–878.
https://doi.org/10.1158/1535-7163.MCT-16-0641
Published: 02 May 2017
View article titled, Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers
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Includes: Supplementary data
Journal Articles

DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma

Dongwei Li, Kirsten Achilles Poon, Shang-Fan Yu, Randall Dere, MaryAnn Go, Jeffrey Lau, Bing Zheng, Kristi Elkins, Dimitry Danilenko, Katherine R. Kozak, Pamela Chan, Josefa Chuh, Xiaoyan Shi, Denise Nazzal, Franklin Fuh, Jacqueline McBride, Vanitha Ramakrishnan, Ruth de Tute, Andy Rawstron, Andrew S. Jack, Rong Deng, Yu-Waye Chu, David Dornan, Marna Williams, William Ho, Allen Ebens, Saileta Prabhu, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (7): 1255–1265.
https://doi.org/10.1158/1535-7163.MCT-12-1173
Published: 07 July 2013
View article titled, DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma
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Includes: Supplementary data
Journal Articles

FcRL5 as a Target of Antibody–Drug Conjugates for the Treatment of Multiple Myeloma

Kristi Elkins, Bing Zheng, MaryAnn Go, Dionysos Slaga, Changchun Du, Suzie J. Scales, Shang-Fan Yu, Jacqueline McBride, Ruth de Tute, Andy Rawstron, Andrew S. Jack, Allen Ebens, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (10): 2222–2232.
https://doi.org/10.1158/1535-7163.MCT-12-0087
Published: 09 October 2012
View article titled, FcRL5 as a Target of Antibody–Drug Conjugates for the Treatment of Multiple Myeloma
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Includes: Supplementary data
Journal Articles

In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

Bing Zheng, Reina N. Fuji, Kristi Elkins, Shang-Fan Yu, Franklin K. Fuh, Josefa Chuh, Christine Tan, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Marna Williams, Elena McDorman, Dan Eaton, Allen Ebens, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2937–2946.
https://doi.org/10.1158/1535-7163.MCT-09-0369
Published: 12 October 2009
View article titled, <em>In vivo</em> effects of targeting CD79b with antibodies and antibody-drug conjugates
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