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Alexander J. Lazar
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Journal Articles

Loss of the DNA Repair Gene RNase H2 Identifies a Unique Subset of DDR-Deficient Leiomyosarcomas

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Michael S. Nakazawa, Ian M. Silverman, Victoria Rimkunas, Artur Veloso, Dominik Glodzik, Adrienne Johnson, Toshiro K. Ohsumi, Shreyaskumar R. Patel, Anthony P. Conley, Christina L. Roland, Pamela T. Soliman, Hannah C. Beird, Chia-Chin Wu, Davis R. Ingram, Rossana Lazcano, Dawon Song, Khalida M. Wani, Alexander J. Lazar, Timothy A. Yap, Wei-Lien Wang, J. Andrew Livingston
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (7): 1057–1065.
https://doi.org/10.1158/1535-7163.MCT-23-0761
Published: 02 July 2024
View articletitled, Loss of the DNA Repair Gene RNase H2 Identifies a Unique Subset of DDR-Deficient Leiomyosarcomas
Open the PDF for Loss of the DNA Repair Gene RNase H2 Identifies a Unique Subset of DDR-Deficient Leiomyosarcomas in another window
Includes: Supplementary data
Journal Articles

Abstract C016: Evaluating clinical biomarkers of FHD-286, a potent and selective inhibitor of BRG1/BRM, in metastatic uveal melanoma

Free
Jessica Wan, Kim Horrigan, GiNell Elliott, Liv Johannessen, Mike Collins, Alexander J. Lazar, Dillon Corrigan, Caitlin Patriquin, Sam Agresta, Jessica Piel, Martin Hentemann
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C016.
https://doi.org/10.1158/1535-7163.TARG-23-C016
Published: 01 December 2023
View articletitled, Abstract C016: Evaluating clinical biomarkers of FHD-286, a potent and selective inhibitor of BRG1/BRM, in metastatic uveal melanoma
Journal Articles

Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma

Open Access
Yifei Wang, Xiangjun Tian, Wendong Zhang, Zhongting Zhang, Rossana Lazcano, Pooja Hingorani, Michael E. Roth, Jonathan D. Gill, Douglas J. Harrison, Zhaohui Xu, Sylvester Jusu, Sankaranarayanan Kannan, Jing Wang, Alexander J. Lazar, Eric J. Earley, Stephen W. Erickson, Tara Gelb, Philip Huxley, Johanna Lahdenranta, Gemma Mudd, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Edward A. Kolb, Richard Gorlick
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 903–913.
https://doi.org/10.1158/1535-7163.MCT-21-0836
Published: 01 June 2022
View articletitled, Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma
Open the PDF for Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma in another window
Includes: Supplementary data
Journal Articles

Genomics, Morphoproteomics, and Treatment Patterns of Patients with Alveolar Soft Part Sarcoma and Response to Multiple Experimental Therapies

Free
Roman Groisberg, Jason Roszik, Anthony P. Conley, Alexander J. Lazar, Daniella E. Portal, David S. Hong, Aung Naing, Cynthia E. Herzog, Neeta Somaiah, Maria A. Zarzour, Shreyaskumar Patel, Robert E. Brown, Vivek Subbiah
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (5): 1165–1172.
https://doi.org/10.1158/1535-7163.MCT-19-0579
Published: 04 May 2020
View articletitled, Genomics, Morphoproteomics, and Treatment Patterns of Patients with Alveolar Soft Part Sarcoma and Response to Multiple Experimental Therapies
Open the PDF for Genomics, Morphoproteomics, and Treatment Patterns of Patients with Alveolar Soft Part Sarcoma and Response to Multiple Experimental Therapies in another window
Journal Articles

Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients

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J. Andrew Livingston, Wei-Lien Wang, Jen-Wei Tsai, Alexander J. Lazar, Cheuk Hong Leung, Heather Lin, Shailesh Advani, Najat Daw, Janice Santiago-O'Farrill, Mario Hollomon, Nancy B. Gordon, Eugenie S. Kleinerman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (6): 1315–1323.
https://doi.org/10.1158/1535-7163.MCT-17-0901
Published: 31 May 2018
View articletitled, Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients
Open the PDF for Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients in another window
Includes: Supplementary data
Journal Articles

Targeting the PI3K/mTOR Axis, Alone and in Combination with Autophagy Blockade, for the Treatment of Malignant Peripheral Nerve Sheath Tumors

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Markus P. Ghadimi, Gonzalo Lopez, Keila E. Torres, Roman Belousov, Eric D. Young, Jeffery Liu, Kari J. Brewer, Aviad Hoffman, Kristelle Lusby, Alexander J. Lazar, Raphael E. Pollock, Dina Lev
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (8): 1758–1769.
https://doi.org/10.1158/1535-7163.MCT-12-0015
Published: 08 August 2012
View articletitled, Targeting the PI3K/mTOR Axis, Alone and in Combination with Autophagy Blockade, for the Treatment of Malignant Peripheral Nerve Sheath Tumors
Open the PDF for Targeting the PI3K/mTOR Axis, Alone and in Combination with Autophagy Blockade, for the Treatment of Malignant Peripheral Nerve Sheath Tumors in another window
Includes: Supplementary data
Journal Articles

Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates

Free
Scott E. Woodman, Jonathan C. Trent, Katherine Stemke-Hale, Alexander J. Lazar, Sabrina Pricl, Giovanni M. Pavan, Maurizio Fermeglia, Y.N. Vashisht Gopal, Dan Yang, Donald A. Podoloff, Doina Ivan, Kevin B. Kim, Nicholas Papadopoulos, Patrick Hwu, Gordon B. Mills, Michael A. Davies
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (8): 2079–2085.
https://doi.org/10.1158/1535-7163.MCT-09-0459
Published: 14 August 2009
View articletitled, Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates
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Includes: Supplementary data
Journal Articles

Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor

Free
Changye Y. Zou, Kerrington D. Smith, Quan-Sheng Zhu, Jun Liu, Ian E. McCutcheon, John M. Slopis, Funda Meric-Bernstam, Zhenghong Peng, William G. Bornmann, Gordon B. Mills, Alexander J. Lazar, Raphael E. Pollock, Dina Lev
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (5): 1157–1168.
https://doi.org/10.1158/1535-7163.MCT-08-1008
Published: 13 May 2009
View articletitled, Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor
Open the PDF for Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor in another window