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Journal Articles

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

Margaret A. Park, Roland Reinehr, Dieter Häussinger, Christina Voelkel-Johnson, Besim Ogretmen, Adly Yacoub, Steven Grant, Paul Dent

Mol Cancer Ther (2010) 9 (8): 2220–2231.

https://doi.org/10.1158/1535-7163.MCT-10-0274

Published: 09 August 2010

View article titled, Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

Includes: Supplementary data

Journal Articles

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca²⁺-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

Teneille Walker, Clint Mitchell, Margaret A. Park, Adly Yacoub, Mohamed Rahmani, Dieter Häussinger, Roland Reinehr, Christina Voelkel-Johnson, Paul B. Fisher, Steven Grant, Paul Dent

Mol Cancer Ther (2010) 9 (5): 1378–1395.

https://doi.org/10.1158/1535-7163.MCT-09-1131

Published: 09 May 2010

View article titled, 17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

Includes: Supplementary data

Journal Articles

Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy

Luni Emdad, Devanand Sarkar, Seok-Geun Lee, Zhao Zhong Su, Byoung Kwon Yoo, Rupesh Dash, Adly Yacoub, Christine E. Fuller, Khalid Shah, Paul Dent, Jeffrey N. Bruce, Paul B. Fisher

Mol Cancer Ther (2010) 9 (1): 79–88.

https://doi.org/10.1158/1535-7163.MCT-09-0752

Published: 12 January 2010

View article titled, Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy

Journal Articles

MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

Margaret A. Park, Teneille Walker, Aditi Pandya Martin, Jeremy Allegood, Nicollaq Vozhilla, Luni Emdad, Devanand Sarkar, Mohammed Rahmani, Martin Graf, Adly Yacoub, Costas Koumenis, Sarah Spiegel, David T. Curiel, Christina Voelkel-Johnson, Steven Grant, Paul B. Fisher, Paul Dent

Mol Cancer Ther (2009) 8 (5): 1280–1291.

https://doi.org/10.1158/1535-7163.MCT-09-0073

Published: 13 May 2009

View article titled, MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

Includes: Supplementary data

Journal Articles

Inhibition of vimentin or β₁ integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

Xueping Zhang, Marcia V. Fournier, Joy L. Ware, Mina J. Bissell, Adly Yacoub, Zendra E. Zehner

Mol Cancer Ther (2009) 8 (3): 499–508.

https://doi.org/10.1158/1535-7163.MCT-08-0544

Published: 13 March 2009

View article titled, Inhibition of vimentin or β1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

Journal Articles

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

Margaret A. Park, Guo Zhang, Clint Mitchell, Mohamed Rahmani, Hossein Hamed, Michael P. Hagan, Adly Yacoub, David T. Curiel, Paul B. Fisher, Steven Grant, Paul Dent

Mol Cancer Ther (2008) 7 (9): 2633–2648.

https://doi.org/10.1158/1535-7163.MCT-08-0400

Published: 11 September 2008

View article titled, Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

Includes: Supplementary data

Journal Articles

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Hossein Hamed, William Hawkins, Clint Mitchell, Donna Gilfor, Guo Zhang, Xin-Yan Pei, Yun Dai, Michael P. Hagan, John D. Roberts, Adly Yacoub, Steven Grant, Paul Dent

Mol Cancer Ther (2008) 7 (3): 616–629.

https://doi.org/10.1158/1535-7163.MCT-07-2376

Published: 17 March 2008

View article titled, Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Journal Articles

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

Adly Yacoub, Pankaj Gupta, Margaret A. Park, Mohammed Rhamani, Hossein Hamed, David Hanna, Guo Zhang, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Costas Koumenis, David T. Curiel, Steven Grant, Paul B. Fisher, Paul Dent

Mol Cancer Ther (2008) 7 (2): 314–329.

https://doi.org/10.1158/1535-7163.MCT-07-2150

Published: 15 February 2008

View article titled, Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

Journal Articles

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Adly Yacoub, Margaret A. Park, Pankaj Gupta, Mohammed Rahmani, Guo Zhang, Hossein Hamed, David Hanna, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Moira Sauane, Nicollaq Vozhilla, Sarah Spiegel, Costas Koumenis, Martin Graf, David T. Curiel, Steven Grant, Paul B. Fisher, Paul Dent

Mol Cancer Ther (2008) 7 (2): 297–313.

https://doi.org/10.1158/1535-7163.MCT-07-2166

Published: 15 February 2008

View article titled, Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Journal Articles

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

Clint Mitchell, Maragret A. Park, Guo Zhang, Adly Yacoub, David T. Curiel, Paul B. Fisher, John D. Roberts, Steven Grant, Paul Dent

Mol Cancer Ther (2007) 6 (12): 3101–3112.

https://doi.org/10.1158/1535-7163.MCT-07-0561

Published: 18 December 2007

View article titled, Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

Journal Articles

Radiation-induced cell signaling: inside-out and outside-in

Kristoffer Valerie, Adly Yacoub, Michael P. Hagan, David T. Curiel, Paul B. Fisher, Steven Grant, Paul Dent

Mol Cancer Ther (2007) 6 (3): 789–801.

https://doi.org/10.1158/1535-7163.MCT-06-0596

Published: 15 March 2007

View article titled, Radiation-induced cell signaling: inside-out and outside-in

Journal Articles

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

Clint Mitchell, Margaret A. Park, Guo Zhang, Song Iy Han, Hisashi Harada, Richard A. Franklin, Adly Yacoub, Pin-Lan Li, Philip B. Hylemon, Steven Grant, Paul Dent

Mol Cancer Ther (2007) 6 (2): 618–632.

https://doi.org/10.1158/1535-7163.MCT-06-0532

Published: 16 February 2007

View article titled, 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

Journal Articles

H-RAS V12–induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent

Rubén W. Carón, Adly Yacoub, Xiaoyu Zhu, Clint Mitchell, Song Iy Han, Takehiko Sasazuki, Senji Shirasawa, Michael P. Hagan, Steven Grant, Paul Dent

Mol Cancer Ther (2005) 4 (2): 243–255.

https://doi.org/10.1158/1535-7163.243.4.2

Published: 15 February 2005

View article titled, H-RAS V12–induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent

Journal Articles

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival

Rubén W. Carón, Adly Yacoub, Min Li, Xiaoyu Zhu, Clint Mitchell, Young Hong, William Hawkins, Takehiko Sasazuki, Senji Shirasawa, Alan P. Kozikowski, Philip A. Dennis, Michael P. Hagan, Steven Grant, Paul Dent

Mol Cancer Ther (2005) 4 (2): 257–270.

https://doi.org/10.1158/1535-7163.257.4.2

Published: 15 February 2005

View article titled, Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival

Journal Articles

MDA-7 (Interleukin-24) Inhibits the Proliferation of Renal Carcinoma Cells and Interacts with Free Radicals to Promote Cell Death and Loss of Reproductive Capacity

Adly Yacoub, Clint Mitchell, Jessica Brannon, Elizabeth Rosenberg, Liang Qiao, Robert McKinstry, W. Marston Linehan, Zao-shong Su, Devanand Sarkar, Irina V. Lebedeva, Kristoffer Valerie, Rahul V. Gopalkrishnan, Steven Grant, Paul B. Fisher, Paul Dent

Mol Cancer Ther (2003) 2 (7): 623–632.

Published: 25 July 2003

View article titled, MDA-7 (Interleukin-24) Inhibits the Proliferation of Renal Carcinoma Cells and Interacts with Free Radicals to Promote Cell Death and Loss of Reproductive Capacity

NARROW

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca²⁺-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy

MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

Inhibition of vimentin or β₁ integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

Radiation-induced cell signaling: inside-out and outside-in

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

H-RAS V12–induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival

MDA-7 (Interleukin-24) Inhibits the Proliferation of Renal Carcinoma Cells and Interacts with Free Radicals to Promote Cell Death and Loss of Reproductive Capacity

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