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Adeela Kamal
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Journal Articles

A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models

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Hanne Hillen, Aurélie Candi, Bart Vanderhoydonck, Weronika Kowalczyk, Leticia Sansores-Garcia, Elena C. Kesikiadou, Leen Van Huffel, Lore Spiessens, Marnik Nijs, Erik Soons, Wanda Haeck, Hugo Klaassen, Wim Smets, Stéphane A. Spieser, Arnaud Marchand, Patrick Chaltin, Fabrice Ciesielski, Francois Debaene, Lei Chen, Adeela Kamal, Stephen L. Gwaltney, Matthias Versele, Georg A. Halder
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (1): 3–13.
https://doi.org/10.1158/1535-7163.MCT-22-0681
Published: 03 January 2024
View articletitled, A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models
Open the PDF for A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models in another window
Includes: Supplementary data
Journal Articles

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4

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Jay Harper, Christopher Lloyd, Nazzareno Dimasi, Dorin Toader, Rose Marwood, Leeanne Lewis, David Bannister, Jelena Jovanovic, Ryan Fleming, Francois D'Hooge, Shenlan Mao, Allison M. Marrero, Martin Korade, III, Patrick Strout, Linda Xu, Cui Chen, Leslie Wetzel, Shannon Breen, Lilian van Vlerken-Ysla, Sanjoo Jalla, Marlon Rebelatto, Haihong Zhong, Elaine M. Hurt, Mary Jane Hinrichs, Keven Huang, Philip W. Howard, David A. Tice, Robert E. Hollingsworth, Ronald Herbst, Adeela Kamal
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (8): 1576–1587.
https://doi.org/10.1158/1535-7163.MCT-16-0825
Published: 02 August 2017
View articletitled, Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4
Open the PDF for Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4 in another window
Includes: Supplementary data
Journal Articles

Abstract B170: Discovery of tubulysin payloads for antibody drug conjugates with potent in vitro activity and in vivo efficacy in solid tumor models

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Dorin Toader, Jay Harper, Chris Lloyd, Rose Marwood, David Bannister, Shenlan Mao, Cui (Tracy) Chen, Haihon (Helen) Zhong, Vahe Bedian, Fengjiang Wang, Lakshmaiah Gingipalli, Melisa Vasbinder, Pamela Thompson, Ryan Fleming, Byniam Bezabeh, Nazzareno Dimasi, Changshou Gao, Adeela Kamal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B170.
https://doi.org/10.1158/1535-7163.TARG-15-B170
Published: 01 December 2015
View articletitled, Abstract B170: Discovery of tubulysin payloads for antibody drug conjugates with potent in vitro activity and in vivo efficacy in solid tumor models
Journal Articles

Abstract A49: Anti-DLL4 antibodies inhibit cancer stem cells in small cell lung cancer.

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Patrick Strout, Martin Korade, Ching Ching Leow, Ivan Inigo, Suneetha Thomas, Elaine Hurt, Jon Chesebrough, Adeela Kamal, Song Cho
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A49.
https://doi.org/10.1158/1535-7163.TARG-13-A49
Published: 01 November 2013
View articletitled, Abstract A49: Anti-DLL4 antibodies inhibit cancer stem cells in small cell lung cancer.
Journal Articles

Abstract B233: c‐Met antagonist Avimer™ polypeptide that exhibits potent in vivo and in vitro inhibitor activity

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Song Cho, Richard Smith, Amy Duguay, Peng Li, Alice Bakker, Ben Alba, Melissa Thomas, Wayne To, Josh Silverman, Candace Swimmer, Kevin Moore, Patrick Strout, Kevin Bobofchak, Mike McCarthy, Kalyani Pemmaraju, Gerard Lacourciere, Qin Zhou, Melissa Damschroder, Herren Wu, Steve Coats, Adeela Kamal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B233.
https://doi.org/10.1158/1535-7163.TARG-09-B233
Published: 10 December 2009
View articletitled, Abstract B233: c‐Met antagonist Avimer™ polypeptide that exhibits potent in vivo and in vitro inhibitor activity
Journal Articles

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

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Karen Lundgren, Hong Zhang, John Brekken, Nanni Huser, Rachel E. Powell, Noel Timple, David J. Busch, Laura Neely, John L. Sensintaffar, Yong-ching Yang, Andres McKenzie, Jessica Friedman, Robert Scannevin, Adeela Kamal, Kevin Hong, Srinivas R. Kasibhatla, Marcus F. Boehm, Francis J. Burrows
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (4): 921–929.
https://doi.org/10.1158/1535-7163.MCT-08-0758
Published: 16 April 2009
View articletitled, BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
Open the PDF for BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90 in another window
Journal Articles

Proteomics analysis of Hsp90 modulation

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Jing Wei, Mark Daniels, Ben Colson, Diem Tran, John Sensintaffar, Noel Timple, Naveen Dakappagari, Adeela Kamal, Karen Lundgren, Ingrid Joseph, Shabnam Tangri, Chris Storgard, Alessandra Cesano, Steve French, Steve French, Francis Burrows, Alex Buko
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B160.
Published: 01 November 2007
View articletitled, Proteomics analysis of Hsp90 modulation
Journal Articles

BIIB021 is a small molecule inhibitor of the heat shock protein, Hsp90, that shows potent anti-tumor activity in preclinical models

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Karen Lundgren, Hong Zhang, Adeela Kamal, Rachel Lough, Noelito Timple, John Sensintaffar, David Busch, Cindy Yang, Laura Neely, Samina Khan, Kevin Hong, Srinivas Kasibhatla, Marcus Boehm, Francis Burrows
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B161.
Published: 01 November 2007
View articletitled, BIIB021 is a small molecule inhibitor of the heat shock protein, Hsp90, that shows potent anti-tumor activity in preclinical models