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A. Robert MacLeod
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Journal Articles

Abstract B197: Selective depletion of YAP1 with next-generation antisense oligonucleotides leads to immune cell infiltration and tumor regression in mouse models of HCC

Youngsoo Kim, Joanna Schmidt, Minji Jo, Jing Yi, Tianyuan Zhou, Xiaolin Luo, Sun Young Yim, Ju-Seog Lee, Randy L. Johnson, Brett P. Monia, Gordon Mills, A. Robert MacLeod
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): B197.
https://doi.org/10.1158/1535-7163.TARG-17-B197
Published: 01 January 2018
View article titled, Abstract B197: Selective depletion of YAP1 with next-generation antisense oligonucleotides leads to immune cell infiltration and tumor regression in mouse models of HCC
Journal Articles

Abstract LB-B20: High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T cells and produce anti-tumor effects in syngeneic tumor models

Alexey S. Revenko, Charles Sinclair, Ben Johnson, Lisa Hettrick, Alison Peter, Anna Staniszewska, Adina Hughes, Linda Sandin, Molly Taylor, Stephanie Klein, Andy Watt, Brett Monia, Mark Edbrooke, A. Robert MacLeod
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): LB-B20.
https://doi.org/10.1158/1535-7163.TARG-17-LB-B20
Published: 01 January 2018
View article titled, Abstract LB-B20: High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T cells and produce anti-tumor effects in syngeneic tumor models
Journal Articles

Abstract A73: Antisense oligonucleotides targeting ENO2 have selective anti-proliferative effects in glioblastoma cell with 1p36 genomic loss

Maria Shahmoradgoli, Curt Mazur, Youngsoo Kim, Brett P Monia, A. Robert Macleod, Florian M Muller, Christopher E Hart
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): A73.
https://doi.org/10.1158/1535-7163.TARG-15-A73
Published: 01 December 2015
View article titled, Abstract A73: Antisense oligonucleotides targeting ENO2 have selective anti-proliferative effects in glioblastoma cell with 1p36 genomic loss
Journal Articles

Abstract B223: Selective downregulation of interferon regulatory factor 4 by generation 2.5 antisense oligonucleotides induces strong apoptosis and sensitizes multiple myeloma cells to lenalidomide or bortezomib.

Tianyuan Zhou, Joanna Schmidt, Ari Jerue, Minji Jo, Youngsoo Kim, A. Robert MacLeod
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B223.
https://doi.org/10.1158/1535-7163.TARG-13-B223
Published: 01 November 2013
View article titled, Abstract B223: Selective downregulation of interferon regulatory factor 4 by generation 2.5 antisense oligonucleotides induces strong apoptosis and sensitizes multiple myeloma cells to lenalidomide or bortezomib.
Journal Articles

Abstract A259: Characterization of next generation (Gen2.5) KRAS antisense inhibitors in NSCLC, PDAC, and CRC models.

Alexey S. Revenko, Gourab Bhattachrjee, Chris May, Brett P. Monia, A. Robert MacLeod
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A259.
https://doi.org/10.1158/1535-7163.TARG-13-A259
Published: 01 November 2013
View article titled, Abstract A259: Characterization of next generation (Gen2.5) KRAS antisense inhibitors in NSCLC, PDAC, and CRC models.
Journal Articles

Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression In vivo

Christian Thomas, Amina Zoubeidi, Hidetoshi Kuruma, Ladan Fazli, Francois Lamoureux, Eliana Beraldi, Brett P. Monia, A. Robert MacLeod, Joachim W. Thüroff, Martin E. Gleave
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (2): 347–359.
https://doi.org/10.1158/1535-7163.MCT-10-0850
Published: 08 February 2011
View article titled, Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression <em>In vivo</em>
Open the PDF for Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression <em>In vivo</em> in another window
Includes: Supplementary data
Journal Articles

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

Marielle Fournel, Claire Bonfils, Yu Hou, Pu Theresa Yan, Marie-Claude Trachy-Bourget, Ann Kalita, Jianhong Liu, Ai-Hua Lu, Nancy Z. Zhou, Marie-France Robert, Jeffrey Gillespie, James J. Wang, Hélène Ste-Croix, Jubrail Rahil, Sylvain Lefebvre, Oscar Moradei, Daniel Delorme, A. Robert MacLeod, Jeffrey M. Besterman, Zuomei Li
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (4): 759–768.
https://doi.org/10.1158/1535-7163.MCT-07-2026
Published: 15 April 2008
View article titled, MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <em>in vitro</em> and <em>in vivo</em>
Open the PDF for MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <em>in vitro</em> and <em>in vivo</em> in another window
Includes: Supplementary data