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Research Article March 20 2023
Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
Mol Cancer Ther MCT-22-0627.
Research Article March 20 2023
Arginase 1/2 inhibitor OATD-02: from discovery to first-in-man setup in cancer immunotherapy
Bartlomiej Borek; Julita Nowicka; Anna Gzik; Marek Dziegielewski; Karol Jedrzejczak; Joanna Brzezinska; Marcin Grzybowski; Paulina Stanczak; Paulina Pomper; Agnieszka Zagozdzon; Tomasz Rejczak; Krzysztof Matyszewski; Adam Golebiowski; Jacek Olczak; Kamil Lisiecki; Magdalena Tyszkiewicz; Magdalena Kania; Sylwia Piasecka; Anna Cabaj; Paulina Dera; Krzysztof Mulewski; Jacek Chrzanowski; Damian Kusmirek; Elzbieta Sobolewska; Marta Magdycz; Lukasz Mucha; Marek Masnyk; Jakub Golab; Marcin Nowotny; Elzbieta Nowak; Agnieszka Napiorkowska-Gromadzka; Stanislaw Pikul; Radoslaw Jazwiec; Karolina Dzwonek; Pawel Dobrzanski; Michael Meyring; Krzysztof Skowronek; Piotr Iwanowski; Zbigniew Zaslona; Roman Blaszczyk
Mol Cancer Ther MCT-22-0721.
Research Article March 15 2023
Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells
Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
Mol Cancer Ther MCT-22-0415.
Research Article March 15 2023
3D-informed targeting of the Trop-2 signal-activation site drives selective cancer vulnerability
Emanuela Guerra; Marco Trerotola; Valeria Relli; Rossano Lattanzio; Romina Tripaldi; Martina Ceci; Khouloud Boujnah; Ludovica Pantalone; Andrea Sacchetti; Kristina M. Havas; Pasquale Simeone; Nicole Travali; Patrizia Querzoli; Massimo Pedriali; Pietro Roversi; Manuela Iezzi; Nicola Tinari; Laura Antolini; Saverio Alberti
Mol Cancer Ther MCT-22-0352.
Research Article March 13 2023
Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer
Imran Khan; Brunilde Gril; Anurag N. Paranjape; Christina M. Robinson; Simone Difilippantonio; Wojciech Biernat; Michał Bieńkowski; Rafal Pęksa; Renata Duchnowska; Jacek Jassem; Priscilla K. Brastianos; Philippe Metellus; Emilie Bialecki; Carolyn C. Woodroofe; Haitao Wu; Rolf E. Swenson; Patricia S. Steeg
Mol Cancer Ther MCT-22-0815.
Research Article March 13 2023
Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
Aatman S. Doshi; Susan Cantin; Marylens Hernandez; Srimathi Srinivasan; Sharon Tentarelli; Matthew Griffin; Yanjun Wang; Petar Pop-Damkov; Laura B. Prickett; Cecilia Kankkonen; Minhui Shen; Maryann San Martin; Song Wu; M Paola Castaldi; Hormas Ghadially; Jeffrey Varnes; Sonya Gales; David Henry; Clare Hoover; Deanna A. Mele; Iain Simpson; Eric T. Gangl; Scott N. Mlynarski; M. Raymond V. Finlay; Lisa Drew; Stephen E. Fawell; Wenlin Shao; Alwin G. Schuller
Mol Cancer Ther MCT-22-0431.
Research Article March 8 2023
Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib Plus Osimertinib in an EGFR-Mutation Positive, MET-Amplified Non-Small Cell Lung Cancer Model
Mol Cancer Ther MCT-22-0193.
Research Article February 23 2023
IMiDs augment CD3-bispecific antibody induced CD8+ cell cytotoxicity and expansion by enhancing IL-2 production
Mol Cancer Ther MCT-22-0498.
Research Article February 20 2023
Tumor and stromal cell targeting with Nintedanib and Alpelisib overcomes intrinsic bladder cancer resistance
Miriam Marqués; Sonia Corral; María Sánchez-Díaz; Natalia del Pozo; Jaime Martínez de Villarreal; Norbert Schweifer; Ivana Zagorac; Frank Hilberg; Francisco X. Real
Mol Cancer Ther MCT-21-0667.
Research Article February 14 2023
Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death.
Rita A. Avelar; Amy J. Armstrong; Gracie Carvette; Riya Gupta; Noah Puleo; Jose A. Colina; Peronne Joseph; Alexander M. Sobeck; Caitlin M. O'Connor; Brynne Raines; Agharnan Gandhi; Michele L. Dziubinski; Daniel S. Ma; Kimberly Resnick; Sareena Singh; Kristine Zanotti; Christa Nagel; Steven Waggoner; Dafydd G. Thomas; Stephanie L. Skala; Junran Zhang; Goutham Narla; Analisa DiFeo
Mol Cancer Ther MCT-21-0880.
Research Article February 10 2023
A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE)
Elizabeth Pan; Wanling Xie; Archana Ajmera; Arlene Araneta; Christina Jamieson; Edmund Folefac; Arif Hussain; Christos E. Kyriakopoulos; Adam Olson; Mamta Parikh; Rahul Parikh; Biren Saraiya; S. Percy Ivy; Eliezer M. Van Allen; Neal I. Lindeman; Bose S. Kochupurakkal; Geoffrey I. Shapiro; Rana R. McKay
Mol Cancer Ther MCT-22-0583.
Review Article February 10 2023
Current Status and Challenges of Vaccination Therapy for Glioblastoma
Mol Cancer Ther MCT-22-0503.
Research Article February 10 2023
Targeting Glutamine Metabolism with a Novel Na+/K+-ATPase Inhibitor RX108 in Hepatocellular Carcinoma
Daoyan Wei; Dongmei Chen; Hongyuan Mou; Sharmistha Chakraborty; Bo Wei; Lin Tan; Philip L. Lorenzi; Xiangping Qian; Peiying Yang
Mol Cancer Ther MCT-22-0490.
Research Article February 10 2023
Efficacious Combination Drug Treatment for Colorectal Cancer that Overcomes Resistance to KRAS G12C Inhibitors
Hiroyuki Matsubara; Hiroyuki Miyoshi; Fumihiko Kakizaki; Tomonori Morimoto; Kenji Kawada; Takehito Yamamoto; Kazutaka Obama; Yoshiharu Sakai; Makoto Mark Taketo
Mol Cancer Ther MCT-22-0411.
Research Article February 10 2023
Bepotastine sensitizes ovarian cancer to PARP inhibitors through suppressing NF-κB-triggered SASP in cancer-associated fibroblasts
Ping Jin; Xin Li; Yu Xia; Huayi Li; Xiaoting Li; Zong-Yuan Yang; Zhen Wang; Cheng Xu; Tian Fang; Dongchen Zhou; Xiaoming Xiong; Si-Yuan Wang; Sen Xu; Qinglei Gao
Mol Cancer Ther MCT-22-0396.
Research Article February 10 2023
Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T Cell Activation in Tumors
Ben Umiker; Yasmin Hashambhoy-Ramsay; Jeff Smith; Tanzila Rahman; Amy Mueller; Rachel Davidson; Christina Meyer; Gayatri Patankar; Mohammad Murshid. Alam; Sarah Jaffe; Kristin Krukenberg; Allison Goodman; Vikki Spaulding; Michelle Priess; Abha Dhaneshwar; Masie Wong; Alexa Diiorio; Kristin O'Malley; Lara McGrath; Margaret Willer; Lauren Pepper; Monica Gostissa; Katalin Kis-Toth; Dmitri Wiederschain; Heather Cohen; Donald R. Shaffer
Mol Cancer Ther MCT-22-0351.
Research Article February 10 2023
Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma
Jordi Abril-Fornaguera; Laura Torrens; Carmen Andreu-Oller; Juan Carrillo-Reixach; Alexander Rialdi; Ugne Balaseviciute; Roser Pinyol; Carla Montironi; Philipp K. Haber; Álvaro Del Río-Álvarez; Montserrat Domingo-Sàbat; Laura Royo; Nicholas K. Akers; Catherine E. Willoughby; Judit Peix; Miguel Torres-Martin; Marc Puigvehi; Stefano Cairo; Margaret Childs; Rudolf Maibach; Rita Alaggio; Piotr Czauderna; Bruce Morland; Bojan Losic; Vincenzo Mazzaferro; Ernesto Guccione; Daniela Sia; Carolina Armengol; Josep M. Llovet
Mol Cancer Ther MCT-22-0335.
Review Article February 7 2023
Targeting senescence as a therapeutic opportunity for triple-negative breast cancer
Bruno de Paula; Rosalind Kieran; Samantha Shui Yuan. Koh; Susanne Crocamo; Eliana Abdelhay; Daniel Muñoz-Espín
Mol Cancer Ther MCT-22-0643.
Research Article February 7 2023
SGN-CD228A is an investigational CD228-directed antibody-drug conjugate with potent antitumor activity across a wide spectrum of preclinical solid tumor models
Rebecca Mazahreh; Marsha L. Mason; John J. Gosink; Devra J. Olson; Robert Thurman; Christopher Hale; Lori Westendorf; Thomas A. Pires; Christopher I. Leiske; Markus Carlson; Liem T. Nguyen; Julia H. Cochran; Nicole M. Okeley; Roma Yumul; Steven Jin; Ivan J. Stone; Disha Sahetya; Albina Nesterova; Sean Allred; Kelly M. Hensley; Rachael Hu; Robert Lawrence; Timothy S. Lewis; Sharsti Sandall
Mol Cancer Ther MCT-22-0401.
Research Article February 7 2023
Griseofulvin Radiosensitizes Non-Small Cell Lung Cancer Cells and Activates cGAS
Xing Wang; Natasha Raman; Ghali Lemtiri-Chlieh; Jinhee Chang; Shreya Jagtap; Dipanwita Dutta. Chowdhury; Matthew Ballew; Francesca Anna Carrieri; Triet Nguyen; Katriana Nugent; Travis Peck; Michelle S. Levine; Aaron Chan; Christine Lam; Reem Malek; Tung Hoang; Ryan Phillips; ZhuoAn Cheng; Kekoa Taparra; Nick Connis; Christine L. Hann; Andrew Holland; Phuoc T. Tran; Audrey Lafargue; Hailun Wang
Mol Cancer Ther MCT-22-0191.
Research Article January 31 2023
Payload-binding Fab fragments increase the therapeutic index of MMAE antibody-drug conjugates
Mol Cancer Ther MCT-22-0440.
Research Article January 24 2023
Liposome-encapsulated eribulin shows enhanced antitumor activity over eribulin for combination therapy with anti-PD-1 antibody
Yuki Niwa; Keito Adachi; Kimiyo Tabata; Ryoga Ishida; Koichiro Hotta; Tomomi Ishida; Yuji Mano; Yoichi Ozawa; Yukinori Minoshima; Yasuhiro Funahashi; Taro Semba
Mol Cancer Ther MCT-22-0475.
Research Article January 24 2023
Redundant Signaling as the Predominant mechanism for Resistance to Antibodies Targeting IGF-1R in Cells Derived from Childhood Sarcoma
Terry J. Shackleford; Seethalakshmi Hariharan; Angelina V. Vaseva; Karina Alagoa; Maricruz Espinoza; Hemant K. Bid; Fuyang Li; Haihong Zhong; Doris A. Phelps; Ryan D. Roberts; Hakan Cam; Cheryl A. London; Denis C. Guttridge; Yidong Chen; Manjeet Rao; Yuzuru Shiio; Peter J. Houghton
Mol Cancer Ther MCT-20-0625.
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