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1 June 2010
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A recombinant human phage display-derived antibody, DX-2647, targeting IGF-II blocks the growth of human hepatocellular tumor cells in vitro and in vivo. DX-2647 blocks the binding of IGF-II to a panel of IGFBPs and the mannose-6-phosphate receptor (IGF-IIR). A comparison of the crystal complexes of IGF-II with the Fab from DX-2647 (burgundy) and IGF-II with the IGF-IIR (green) reveals a small area of overlap in the two binding domains (Fab versus IGF-IIR) contributing mechanistically to the observed neutralizing biologic activity of this antibody. For details, see article by Dransfield and colleagues on page 1809 . - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
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Research Articles
ErbB-Inhibitory Protein: A Modified Ectodomain of Epidermal Growth Factor Receptor Synergizes with Dasatinib to Inhibit Growth of Breast Cancer Cells
Jyoti Nautiyal; Yingjie Yu; Amro Aboukameel; Shailender S. Kanwar; Jayanta K. Das; Jianhua Du; Bhaumik B. Patel; Fazlul H. Sarkar; Arun K. Rishi; Ramzi M. Mohammad; Adhip P.N. Majumdar
Na,K-ATPase Subunits as Markers for Epithelial-Mesenchymal Transition in Cancer and Fibrosis
Sigrid A. Rajasekaran; Thu P. Huynh; Daniel G. Wolle; Cromwell E. Espineda; Landon J. Inge; Anna Skay; Charles Lassman; Susanne B. Nicholas; Jeffrey F. Harper; Anna E. Reeves; Mansoor M. Ahmed; James M. Leatherman; James M. Mullin; Ayyappan K. Rajasekaran
Reversible Epithelial to Mesenchymal Transition and Acquired Resistance to Sunitinib in Patients with Renal Cell Carcinoma: Evidence from a Xenograft Study
Hans J. Hammers; Henk M. Verheul; Brenda Salumbides; Rajni Sharma; Michelle Rudek; Janneke Jaspers; Preeti Shah; Leigh Ellis; Li Shen; Silvia Paesante; Karl Dykema; Kyle Furge; Bin T. Teh; George Netto; Roberto Pili
Decitabine Maintains Hematopoietic Precursor Self-Renewal by Preventing Repression of Stem Cell Genes by a Differentiation-Inducing Stimulus
Zhenbo Hu; Soledad Negrotto; Xiaorong Gu; Reda Mahfouz; Kwok Peng Ng; Quteba Ebrahem; Edward Copelan; Harinder Singh; Jaroslaw P. Maciejewski; Yogen Saunthararajah
Evaluation of Selective γ-Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design
Ping Wei; Marlena Walls; Ming Qiu; Richard Ding; Robert H. Denlinger; Anthony Wong; Kosta Tsaparikos; Jitesh P. Jani; Natilie Hosea; Michelle Sands; Sophia Randolph; Tod Smeal
Enhanced Anticancer Effect of the Combination of BIBW2992 and Thymidylate Synthase–Targeted Agents in Non–Small Cell Lung Cancer with the T790M Mutation of Epidermal Growth Factor Receptor
Ken Takezawa; Isamu Okamoto; Junko Tanizaki; Kiyoko Kuwata; Haruka Yamaguchi; Masahiro Fukuoka; Kazuto Nishio; Kazuhiko Nakagawa
Improved Antitumor Activity and Tumor Targeting of NH2-Terminal–Specific PEGylated Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand
Su Young Chae; Tae Hyung Kim; Kyeongsoon Park; Cheng-Hao Jin; Sohee Son; Seulki Lee; Yu Seok Youn; Kwangmeyung Kim; Dong-Gyu Jo; Ick Chan Kwon; Xiaoyuan Chen; Kang Choon Lee
Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice
Vanessa Fritz; Zohra Benfodda; Geneviève Rodier; Corinne Henriquet; François Iborra; Christophe Avancès; Yves Allory; Alexandre de la Taille; Stéphane Culine; Hubert Blancou; Jean Paul Cristol; Françoise Michel; Claude Sardet; Lluis Fajas
Serum Signature of Hypoxia-Regulated Factors Is Associated with Progression after Induction Therapy in Head and Neck Squamous Cell Cancer
Lauren Averett Byers; F. Christopher Holsinger; Merrill S. Kies; William N. William; Adel K. El-Naggar; J. Jack Lee; Jianhua Hu; Adriana Lopez; Hai T. Tran; Shaoyu Yan; Zhiqiang Du; K. Kian Ang; Bonnie S. Glisson; Maria Gabriela Raso; Ignacio I. Wistuba; Jeffrey N. Myers; Waun-Ki Hong; Vali Papadimitrakopoulou; Scott M. Lippman; John V. Heymach
A Novel Plant Homeodomain Finger 10–Mediated Antiapoptotic Mechanism Involving Repression of Caspase-3 in Gastric Cancer Cells
Min Wei; Bingya Liu; Liping Su; Jianfang Li; Jun Zhang; Yingyan Yu; Min Yan; Zhongyin Yang; Xuehua Chen; Jiayun Liu; Xin Lv; Hui Nie; Qing Zhang; Zhong Zheng; Beiqin Yu; Jun Ji; Jianian Zhang; Zhenggang Zhu; Qinlong Gu
A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo
Daniel T. Dransfield; Edward H. Cohen; Qing Chang; Lindsay G. Sparrow; John D. Bentley; Olan Dolezal; Xiaowen Xiao; Thomas S. Peat; Janet Newman; Patricia A. Pilling; Tram Phan; Ilka Priebe; Gemma V. Brierley; Niksa Kastrapeli; Kris Kopacz; Diana Martik; Dina Wassaf; Douglas Rank; Greg Conley; Yan Huang; Timothy E. Adams; Leah Cosgrove
Bortezomib Sensitizes Human Esophageal Squamous Cell Carcinoma Cells to TRAIL–Mediated Apoptosis via Activation of Both Extrinsic and Intrinsic Apoptosis Pathways
Naoko Seki; Uhi Toh; Thomas J. Sayers; Teruhiko Fujii; Motoshi Miyagi; Yoshito Akagi; Jingo Kusukawa; Masayoshi Kage; Kazuo Shirouzu; Hideaki Yamana
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