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1 April 2010
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Cover Image
Cover Image
Immunofluorescent image of untreated A549 lung adenocarcinoma cells. A549 cells seeded on collagen coated coverslips were stained for focal adhesions (antivinculin antibody; green) and F-Actin stress fibers (rhodamine conjugated phalloidin; red). Nuclei were visualized by DAPI staining (blue). It was found that Nutlin 3, a small molecule inhibitor of MDM2, decreases F-actin stress fibers, focal adhesions and invasion in p53wt human cancer cells. For details, see article by Moran and Maki on page 895. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
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Highlights
Research Articles
PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy
Jitesh P. Jani; Joel Arcari; Vincent Bernardo; Samit K. Bhattacharya; David Briere; Bruce D. Cohen; Kevin Coleman; James G. Christensen; Erling O. Emerson; Amy Jakowski; Kenneth Hook; Gerrit Los; James D. Moyer; Ingrid Pruimboom-Brees; Leslie Pustilnik; Ann Marie Rossi; Stefan J. Steyn; Chunyan Su; Konstantinos Tsaparikos; Donn Wishka; Kwansik Yoon; John L. Jakubczak
Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP800
Andrew J. Massey; Joseph Schoepfer; Paul A. Brough; Josef Brueggen; Patrick Chène; Martin J. Drysdale; Ulrike Pfaar; Thomas Radimerski; Stephan Ruetz; Alain Schweitzer; Mike Wood; Carlos Garcia-Echeverria; Michael Rugaard Jensen
ZD6474, a Multitargeted Inhibitor for Receptor Tyrosine Kinases, Suppresses Growth of Gliomas Expressing an Epidermal Growth Factor Receptor Mutant, EGFRvIII, in the Brain
Jia-Jean Yiin; Bo Hu; Paul A. Schornack; Raghvendra S. Sengar; Kun-wei Liu; Haizhong Feng; Frank S. Lieberman; Shih-Hwa Chiou; Jann N. Sarkaria; Erik C. Wiener; Hsin-I Ma; Shi-Yuan Cheng
Treatment with Panobinostat Induces Glucose-Regulated Protein 78 Acetylation and Endoplasmic Reticulum Stress in Breast Cancer Cells
Rekha Rao; Srilatha Nalluri; Ravindra Kolhe; Yonghua Yang; Warren Fiskus; Jianguang Chen; Kyungsoo Ha; Kathleen M. Buckley; Ramesh Balusu; Veena Coothankandaswamy; Atul Joshi; Peter Atadja; Kapil N. Bhalla
Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma
Diana Cirstea; Teru Hideshima; Scott Rodig; Loredana Santo; Samantha Pozzi; Sonia Vallet; Hiroshi Ikeda; Giulia Perrone; Gullu Gorgun; Kishan Patel; Neil Desai; Peter Sportelli; Shweta Kapoor; Shireen Vali; Siddhartha Mukherjee; Nikhil C. Munshi; Kenneth C. Anderson; Noopur Raje
Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor
Robert Mallon; Irwin Hollander; Larry Feldberg; Judy Lucas; Veronica Soloveva; Aranapakam Venkatesan; Christoph Dehnhardt; Efren Delos Santos; Zecheng Chen; Osvaldo dos Santos; Semiramis Ayral-Kaloustian; Jay Gibbons
Bridging the Gap between Cytotoxic and Biologic Therapy with Metronomic Topotecan and Pazopanib in Ovarian Cancer
William M. Merritt; Alpa M. Nick; Amy R. Carroll; Chunhua Lu; Koji Matsuo; Melissa Dumble; Nicholas Jennings; ShuYun Zhang; Yvonne G. Lin; Whitney A. Spannuth; Aparna A. Kamat; Rebecca L. Stone; Mian M.K. Shahzad; Robert L. Coleman; Rakesh Kumar; Anil K. Sood
Pretargeted Immuno–Positron Emission Tomography Imaging of Carcinoembryonic Antigen–Expressing Tumors with a Bispecific Antibody and a 68Ga- and 18F-Labeled Hapten Peptide in Mice with Human Tumor Xenografts
Rafke Schoffelen; Robert M. Sharkey; David M. Goldenberg; Gerben Franssen; William J. McBride; Edmund A. Rossi; Chien-Hsing Chang; Peter Laverman; Jonathan A. Disselhorst; Annemarie Eek; Winette T.A. van der Graaf; Wim J.G. Oyen; Otto C. Boerman
Trifluorothymidine Resistance Is Associated with Decreased Thymidine Kinase and Equilibrative Nucleoside Transporter Expression or Increased Secretory Phospholipase A2
Olaf H. Temmink; Irene V. Bijnsdorp; Henk-Jan Prins; Nienke Losekoot; Auke D. Adema; Kees Smid; Richard J. Honeywell; Bauke Ylstra; Paul P. Eijk; Masakazu Fukushima; Godefridus J. Peters
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