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1 March 2010
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ABT-263 is an inhibitor of the Bcl-2 family members Bcl-2, Bcl-xL, and Bcl-w. Genes that are predictive for sensitivity to ABT-263, as identified by genomic expression profiling, are connected to key Bcl-2 family members as shown in the analysis of the signature genes by Ingenuity Pathways Analysis. In this network, genes that are colored in pink have higher expression in resistant cell lines, while genes colored in green have higher expression in sensitive cell lines. For details, see article by Tahir and colleagues on page 545. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
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Research Articles
2-Methoxyestradiol Inhibits Barrett's Esophageal Adenocarcinoma Growth and Differentiation through Differential Regulation of the β-Catenin–E-Cadherin Axis
Suman Kambhampati; Snigdha Banerjee; Kakali Dhar; Smita Mehta; Inamul Haque; Gopal Dhar; Monami Majumder; Gibanananda Ray; Peter J. Vanveldhuizen; Sushanta K. Banerjee
Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma
Eisuke Kobayashi; Mari Masuda; Robert Nakayama; Hitoshi Ichikawa; Reiko Satow; Miki Shitashige; Kazufumi Honda; Umio Yamaguchi; Ayako Shoji; Naobumi Tochigi; Hideo Morioka; Yoshiaki Toyama; Setsuo Hirohashi; Akira Kawai; Tesshi Yamada
Identification of Expression Signatures Predictive of Sensitivity to the Bcl-2 Family Member Inhibitor ABT-263 in Small Cell Lung Carcinoma and Leukemia/Lymphoma Cell Lines
Stephen K. Tahir; John Wass; Mary K. Joseph; Viswanath Devanarayan; Paul Hessler; Haichao Zhang; Steve W. Elmore; Paul E. Kroeger; Christin Tse; Saul H. Rosenberg; Mark G. Anderson
Association of Polymorphisms in AKT1 and EGFR with Clinical Outcome and Toxicity in Non–Small Cell Lung Cancer Patients Treated with Gefitinib
Elisa Giovannetti; Paolo A. Zucali; Godefridus J. Peters; Filippo Cortesi; Armida D'Incecco; Egbert F. Smit; Alfredo Falcone; Jacobus A. Burgers; Armando Santoro; Romano Danesi; Giuseppe Giaccone; Carmelo Tibaldi
Anacardic Acid Inhibits Estrogen Receptor α–DNA Binding and Reduces Target Gene Transcription and Breast Cancer Cell Proliferation
David J. Schultz; Nalinie S. Wickramasinghe; Margarita M. Ivanova; Susan M. Isaacs; Susan M. Dougherty; Yoannis Imbert-Fernandez; Albert R. Cunningham; Chunyuan Chen; Carolyn M. Klinge
SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Veronica Novotny-Diermayr; Kanda Sangthongpitag; Chang Yong Hu; Xiaofeng Wu; Nina Sausgruber; Pauline Yeo; Gediminas Greicius; Sven Pettersson; Ai Leng Liang; Yung Kiang Loh; Zahid Bonday; Kee Chuan Goh; Hannes Hentze; Stefan Hart; Haishan Wang; Kantharaj Ethirajulu; Jeanette Marjorie Wood
Efficacy of PHA-848125, a Cyclin-Dependent Kinase Inhibitor, on the K-RasG12DLA2 Lung Adenocarcinoma Transgenic Mouse Model: Evaluation by Multimodality Imaging
Anna Degrassi; Micaela Russo; Cristina Nanni; Veronica Patton; Rachele Alzani; Anna M. Giusti; Stefano Fanti; Marina Ciomei; Enrico Pesenti; Gemma Texido
Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor
Emmanuelle J. Meuillet; Song Zuohe; Robert Lemos; Nathan Ihle; John Kingston; Ryan Watkins; Sylvestor A. Moses; Shuxing Zhang; Lei Du-Cuny; Roy Herbst; Jörg J. Jacoby; Li Li Zhou; Ali M. Ahad; Eugene A. Mash; D. Lynn Kirkpatrick; Garth Powis
Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis
Betty Y.K. Law; Mingfu Wang; Dik-Lung Ma; Fawaz Al-Mousa; Francesco Michelangeli; Suk-Hang Cheng; Margaret H.L. Ng; Ka-Fai To; Anthony Y.F. Mok; Rebecca Y.Y. Ko; Sze Kui Lam; Feng Chen; Chi-Ming Che; Pauline Chiu; Ben C.B. Ko
Phase I Combination of Sorafenib and Erlotinib Therapy in Solid Tumors: Safety, Pharmacokinetic, and Pharmacodynamic Evaluation from an Expansion Cohort
Miguel Quintela-Fandino; Christophe Le Tourneau; Ignacio Duran; Eric X. Chen; Lisa Wang; Ming Tsao; Bizhan Bandarchi-Chamkhaleh; Nhu-Ann Pham; Trevor Do; Martha MacLean; Rakesh Nayyar; Michael W. Tusche; Ur Metser; John J. Wright; Tak W. Mak; Lillian L. Siu
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