Skip Nav Destination
Issues
1 November 2010
-
Cover Image
Cover Image
Paclitaxel-dependent mutant Tax 11-6 has a mutation in alpha-tubulin that disrupts microtubule assembly, prevents cytokinesis, and leads to cells that are large and multinucleated. Live cell imaging showed that the disrupted cytoskeleton arose from an increased frequency of microtubule detachment from centrosomes and spindle poles. The presence of paclitaxel prevented microtubule detachment and allowed proliferation as normal diploid cells. For details, see the article by Ganguly and colleagues on page 2914. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Highlights
Therapeutic Discovery
A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells
Tatsuki Kunoh; Takanori Noda; Koichi Koseki; Masayuki Sekigawa; Motoki Takagi; Kazuo Shin-ya; Naoki Goshima; Shun-ichiro Iemura; Tohru Natsume; Shu-ichi Wada; Yukio Mukai; Shinji Ohta; Ryuzo Sasaki; Tamio Mizukami
Preclinical Development
SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics
Andrea D. Basso; Ming Liu; Chaoyang Dai; Kimberly Gray; Lissette Nale; Seema Tevar; Suining Lee; Lianzhu Liang; Abdul Ponery; Bohdan Yaremko; Elizabeth Smith; Huadong Tang; Payal R. Sheth; M. Arshad Siddiqui; Daniel J. Hicklin; Paul Kirschmeier
Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models
Curtis B. Thompson; H. Michael Shepard; Patrick M. O'Connor; Salam Kadhim; Ping Jiang; Ryan J. Osgood; Louis H. Bookbinder; Xiaoming Li; Barry J. Sugarman; Robert J. Connor; Sinisa Nadjsombati; Gregory I. Frost
Molecular Medicine in Practice
Silencing Kinase-Interacting Stathmin Gene Enhances Erlotinib Sensitivity by Inhibiting Ser10 p27 Phosphorylation in Epidermal Growth Factor Receptor–Expressing Breast Cancer
Dongwei Zhang; Ana M. Tari; Ugur Akar; Banu K. Arun; Tiffany A. LaFortune; Rene Nieves-Alicea; Gabriel N. Hortobagyi; Naoto T. Ueno
Letters to the Editor
Advertisement
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
RSS Feeds