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1 August 2009
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Cover Image
Cover Image
The level of Na,K-ATPase α3 subunit (Alexafluor 488 secondary antibody, green) expression by pancreatic cancer cells significantly influenced morphological changes exerted by the cardioglycoside, oleandrin. Nuclear DNA was strongly bound by DAPI (blue). MitoTracker Orange CM-H2XRos (red-orange-yellow) was used to detect alterations in the morphological distribution of mitochondria. For details, see the article by Yang and collegues on page 2319. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Issue Sections
Commentary
Spotlight on Clinical Response
Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates
Scott E. Woodman; Jonathan C. Trent; Katherine Stemke-Hale; Alexander J. Lazar; Sabrina Pricl; Giovanni M. Pavan; Maurizio Fermeglia; Y.N. Vashisht Gopal; Dan Yang; Donald A. Podoloff; Doina Ivan; Kevin B. Kim; Nicholas Papadopoulos; Patrick Hwu; Gordon B. Mills; Michael A. Davies
Minireviews
Research Articles
Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
Jiping Zha; Carol O'Brien; Heidi Savage; Ling-Yuh Huw; Fiona Zhong; Leanne Berry; Gail D. Lewis Phillips; Elizabeth Luis; Guy Cavet; Xiaolan Hu; Lukas C. Amler; Mark R. Lackner
Antitumor efficacy of IPI-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2–positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib
Ching Ching Leow; Jon Chesebrough; Karen T. Coffman; Christine A. Fazenbaker; John Gooya; David Weng; Steve Coats; Dowdy Jackson; Bahija Jallal; Yong Chang
Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations
Issan Yee-San Tam; Elaine Lai-Han Leung; Vicky Pui-Chi Tin; Daniel Tsin-Tien Chua; Alan Dart-Loon Sihoe; Lik-Cheung Cheng; Lap-Ping Chung; Maria Pik Wong
Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death
Changyou Li; Yan Zang; Malabika Sen; Rebecca J. Leeman-Neill; David SK. Man; Jennifer R. Grandis; Daniel E. Johnson
The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer
M. Cecilia Crisanti; Africa F. Wallace; Veena Kapoor; Fabian Vandermeers; Melissa L. Dowling; Luana P. Pereira; Kara Coleman; Barbara G. Campling; Zvi G. Fridlender; Gary D. Kao; Steven M. Albelda
Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity
Terzah M. Horton; Gaye Jenkins; Debananda Pati; Linna Zhang; M. Eileen Dolan; Albert Ribes-Zamora; Alison A. Bertuch; Susan M. Blaney; Shannon L. Delaney; Madhuri Hegde; Stacey L. Berg
Comparison of radiosensitizing effects of the mammalian target of rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell carcinoma
Oleksandr Ekshyyan; Youhua Rong; Xiaohua Rong; Kavita M. Pattani; Fleurette Abreo; Gloria Caldito; John Kai Siung Chang; Federico Ampil; Jonathan Glass; Cherie-Ann O. Nathan
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Frédéric Colland; Etienne Formstecher; Xavier Jacq; Céline Reverdy; Cécile Planquette; Susan Conrath; Virginie Trouplin; Julie Bianchi; Vasily N. Aushev; Jacques Camonis; Alessandra Calabrese; Catherine Borg-Capra; Wolfgang Sippl; Vincent Collura; Guillaume Boissy; Jean-Christophe Rain; Philippe Guedat; Rémi Delansorne; Laurent Daviet
Meayamycin inhibits pre–messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells
Brian J. Albert; Peter A. McPherson; Kristine O'Brien; Nancy L. Czaicki; Vincent DeStefino; Sami Osman; Miaosheng Li; Billy W. Day; Paula J. Grabowski; Melissa J. Moore; Andreas Vogt; Kazunori Koide
Xenogeneic immunization with human tyrosine hydroxylase DNA vaccines suppresses growth of established neuroblastoma
Nicole Huebener; Stefan Fest; Kerstin Hilt; Alexander Schramm; Angelika Eggert; Tahir Durmus; Anja Woehler; Alexander Stermann; Matthias Bleeke; Bianca Baykan; Silke Weixler; Gerhard Gaedicke; Holger N. Lode
Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy
Martin Loignon; Weimin Miao; Lianggao Hu; Andrew Bier; Tarek A. Bismar; P. James Scrivens; Koren Mann; Mark Basik; Amélie Bouchard; Pierre O. Fiset; Zachary Batist; Gerald Batist
Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma
Sanjeev A. Vasudevan; Xiaoyi Shang; Shirong Chang; Ningling Ge; Jose L. Diaz-Miron; Heidi V. Russell; M. John Hicks; Andrew D. Ludwig; Catherine L. Wesson; Susan M. Burlingame; Eugene S. Kim; Javed Khan; Jianhua Yang; Jed G. Nuchtern
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