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1 December 2009
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Nuclear localization of total YB-1 is a classic index of poor prognosis in many types of cancer. The nuclear localization of YB-1 is governed by phosphorylation at S102 leading to enhanced binding to genes associated with tumor growth and drug resistance. The image shows for the first time that glioblastoma multiforme cells express intense levels of activated YB-1 in the nucleus. For details, see article by Gao and colleagues on page 3276.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Issue Sections
Review
Research Articles
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
Sean G. Buchanan; Jorg Hendle; Patrick S. Lee; Christopher R. Smith; Pierre-Yves Bounaud; Katti A. Jessen; Crystal M. Tang; Nanni H. Huser; Jeremy D. Felce; Karen J. Froning; Marshall C. Peterman; Brandon E. Aubol; Steve F. Gessert; J. Michael Sauder; Kenneth D. Schwinn; Marijane Russell; Isabelle A. Rooney; Jason Adams; Barbara C. Leon; Tuan H. Do; Jeff M. Blaney; Paul A. Sprengeler; Devon A. Thompson; Lydia Smyth; Laura A. Pelletier; Shane Atwell; Kevin Holme; Stephen R. Wasserman; Spencer Emtage; Stephen K. Burley; Siegfried H. Reich
Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase
Yuanyuan Gao; Abbas Fotovati; Cathy Lee; Michelle Wang; Gilbert Cote; Emma Guns; Brian Toyota; Damien Faury; Nada Jabado; Sandra E. Dunn
Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non–small cell lung cancer
Rudi Bao; Cheng-Jung Lai; Da-Gong Wang; Hui Qu; Ling Yin; Brian Zifcak; Xu Tao; Jing Wang; Ruzanna Atoyan; Maria Samson; Jeffrey Forrester; Guang-Xin Xu; Steven DellaRocca; Mylissa Borek; Hai-Xiao Zhai; Xiong Cai; Changgeng Qian
Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
Wanhong Xu; Biao Xi; Jieying Wu; Haoyun An; Jenny Zhu; Yama Abassi; Stuart C. Feinstein; Michelle Gaylord; Baoqin Geng; Huifang Yan; Weimin Fan; Meihua Sui; Xiaobo Wang; Xiao Xu
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G
Heather N. Tinsley; Bernard D. Gary; Adam B. Keeton; Wei Zhang; Ashraf H. Abadi; Robert C. Reynolds; Gary A. Piazza
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
Joan M. Carboni; Mark Wittman; Zheng Yang; Francis Lee; Ann Greer; Warren Hurlburt; Stephen Hillerman; Carolyn Cao; Glenn H. Cantor; Janet Dell-John; Cliff Chen; Lorell Discenza; Krista Menard; Aixin Li; George Trainor; Dolatrai Vyas; Robert Kramer; Ricardo M. Attar; Marco M. Gottardis
The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo
Mark Douglas; Alice R. Lim; James R. Porter; Kip West; Melissa M. Pink; Jie Ge; Andrew A. Wylie; Thomas T. Tibbits; Kurtis Biggs; Michael Curtis; Vito J. Palombella; Julian Adams; Christian C. Fritz; Emmanuel Normant
Acknowledgment to Reviewers
Correction
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