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Issues

Volume 8, Issue 10
1 October 2009
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    Cover Image

    issue cover
    Photomicrograph of normal spleen from a cynomolgus monkey (Macaca fascicularis) immunohistochemically stained to identify B-cells with an antibody to CD20 (brown). Depletion of peripheral B-cells and dividing germinal center B-cells of lymphoid tissues was observed in monkeys given an anti-CD79b antibody drug conjugate, anti-CD79b-MCC-DM1. For details, see the article by Zheng and colleagues on page 2937.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Issue Sections

Research Articles

An epidermal growth factor receptor variant III–targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme
John H. Sampson; Gary E. Archer; Duane A. Mitchell; Amy B. Heimberger; James E. Herndon, II; Denise Lally-Goss; Sharon McGehee-Norman; Alison Paolino; David A. Reardon; Allan H. Friedman; Henry S. Friedman; Darell D. Bigner
View articletitled, An epidermal growth factor receptor variant III–targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme
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Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA
Stéphane Vispé; Luc DeVries; Laurent Créancier; Jérome Besse; Sophie Bréand; David J. Hobson; Jesper Q. Svejstrup; Jean-Philippe Annereau; Didier Cussac; Charles Dumontet; Nicolas Guilbaud; Jean-Marc Barret; Christian Bailly
View articletitled, Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA
Supplementary data
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Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1α activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect
Woo Hyung Lee; Young Woo Kim; Jae Hoon Choi; Samuel Carroll Brooks, III; Mi-Ock Lee; Sang Geon Kim
View articletitled, Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1α activity through p70 ribosomal S6 kinase-1 inhibition and H<sub>2</sub>O<sub>2</sub>-scavenging effect
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Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma
Chong-Feng Gao; Qian Xie; Yu-Wen Zhang; Yanli Su; Ping Zhao; Brian Cao; Kyle Furge; Jan Sun; Karen Rex; Tao Osgood; Angela Coxon; Teresa L. Burgess; George F. Vande Woude
View articletitled, Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma
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GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers
Peter Sabbatini; Susan Korenchuk; Jason L. Rowand; Arthur Groy; Qi Liu; Dominic Leperi; Charity Atkins; Melissa Dumble; Jingsong Yang; Kelly Anderson; Ryan G. Kruger; Richard R. Gontarek; Kenneth R. Maksimchuk; Sapna Suravajjala; Russell R. Lapierre; J. Brad Shotwell; Joseph W. Wilson; Stanley D. Chamberlain; Sridhar K. Rabindran; Rakesh Kumar
View articletitled, GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers
Supplementary data
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Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone
Penelope D. Ottewell; Julia K. Woodward; Diane V. Lefley; C. Alyson Evans; Robert E. Coleman; Ingunn Holen
View articletitled, Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone
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Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells
Hongbo Hu; Yubo Chai; Lei Wang; Jinhui Zhang; Hyo Jeong Lee; Sung-Hoon Kim; Junxuan Lü
View articletitled, Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells
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Pharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors
Zacharoula Konsoula; Hong Cao; Alfredo Velena; Mira Jung
View articletitled, Pharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors
Supplementary data
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Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin
Galina Kuznetsov; Karen TenDyke; Murray J. Towle; Hongsheng Cheng; Junke Liu; Joanne P. Marsh; Shawn E.R. Schiller; Mark R. Spyvee; Hu Yang; Boris M. Seletsky; Christina J. Shaffer; Veronique Marceau; Ye Yao; Edward M. Suh; Silvio Campagna; Francis G. Fang; James J. Kowalczyk; Bruce A. Littlefield
View articletitled, Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin
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A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
Michael M. Schmidt; K. Dane Wittrup
View articletitled, A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
Supplementary data
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Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models
Laura G. Daenen; Yuval Shaked; Shan Man; Ping Xu; Emile E. Voest; Robert M. Hoffman; David J. Chaplin; Robert S. Kerbel
View articletitled, Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models
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Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes
Shannon M. Mumenthaler; Patricia Y.B. Ng; Amanda Hodge; David Bearss; Gregory Berk; Sarath Kanekal; Sanjeev Redkar; Pietro Taverna; David B. Agus; Anjali Jain
View articletitled, Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes
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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Sarah E. Golding; Elizabeth Rosenberg; Nicholas Valerie; Isa Hussaini; Mark Frigerio; Xiaoling F. Cockcroft; Wei Yee Chong; Marc Hummersone; Laurent Rigoreau; Keith A. Menear; Mark J. O'Connor; Lawrence F. Povirk; Timothy van Meter; Kristoffer Valerie
View articletitled, Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Supplementary data
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Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators
William R. Wilson; Stephen M. Stribbling; Frederik B. Pruijn; Sophie P. Syddall; Adam V. Patterson; H.D. Sarath Liyanage; Eileen Smith; K. Jane Botting; Moana Tercel
View articletitled, Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine <em>N</em>3 DNA minor groove alkylators
Supplementary data
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BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1–induced apoptosis in breast cancer cells
Uta M. Schneiders; Lilianna Schyschka; Anita Rudy; Angelika M. Vollmar
View articletitled, BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1–induced apoptosis in breast cancer cells
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Quantification of endothelial cell–targeted anti–Bcl-2 therapy and its suppression of tumor growth and vascularization
Harsh Vardhan Jain; Jacques Eduardo Nör; Trachette Levon Jackson
View articletitled, Quantification of endothelial cell–targeted anti–Bcl-2 therapy and its suppression of tumor growth and vascularization
Supplementary data
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In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates
Bing Zheng; Reina N. Fuji; Kristi Elkins; Shang-Fan Yu; Franklin K. Fuh; Josefa Chuh; Christine Tan; Jo-Anne Hongo; Helga Raab; Katherine R. Kozak; Marna Williams; Elena McDorman; Dan Eaton; Allen Ebens; Andrew G. Polson
View articletitled, <em>In vivo</em> effects of targeting CD79b with antibodies and antibody-drug conjugates
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A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells
Tohru Yamada; Rajeshwari R. Mehta; Fatima Lekmine; Konstantin Christov; Marissa L. King; Dibyen Majumdar; Anne Shilkaitis; Albert Green; Laura Bratescu; Craig W. Beattie; Tapas K. Das Gupta
View articletitled, A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells
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Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2
Kenneth K.W. To; Robert W. Robey; Turid Knutsen; Zhirong Zhan; Thomas Ried; Susan E. Bates
View articletitled, Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2
Supplementary data
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Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer
Irene Zinonos; Agatha Labrinidis; Michelle Lee; Vasilios Liapis; Shelley Hay; Vladimir Ponomarev; Peter Diamond; Andrew C.W. Zannettino; David M. Findlay; Andreas Evdokiou
View articletitled, Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer
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Correction

Correction: SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-κB activation, c-Fos/c-Jun expression, and cellular apoptosis
View articletitled, Correction: SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-κB activation, c-Fos/c-Jun expression, and cellular apoptosis
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