Skip to Main Content

Advertisement

American Association for Cancer Research Logo Open Menu
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 8, Issue 1
1 January 2009
Molecular Cancer Therapeutics Cover Image for Volume 8, Issue 1
All Issues
  • Cover Image

    Cover Image

    Issue cover image
    DU145 prostate tumor cells were treated with DMSO or 25 μmol/L luteolin for 12 h. Cells were fixed and stained for actin, 4′,6-diamidino-2-phenylindole, and microtubules, and representative 40 and 60x images were captured. The images demonstrate that exposure to luteolin alters the morphology of cells (they become bigger and flatter in appearance), and reduces the level of F-actin without effecting microtubules. For details, see Coleman et al., in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Issue Sections

Reviews

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy
Nathan T. Ihle; Garth Powis
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Platinum neurotoxicity pharmacogenetics
Sarah R. McWhinney; Richard M. Goldberg; Howard L. McLeod
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Ixabepilone: targeting βIII-tubulin expression in taxane-resistant malignancies
Charles Dumontet; Mary Ann Jordan; Francis F.Y. Lee
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Research Articles

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
Renate Burger; Steven Le Gouill; Yu-Tzu Tai; Reshma Shringarpure; Pierfrancesco Tassone; Paola Neri; Klaus Podar; Laurence Catley; Teru Hideshima; Dharminder Chauhan; Eian Caulder; Claire L. Neilan; Kris Vaddi; Jun Li; Martin Gramatzki; Jordan S. Fridman; Kenneth C. Anderson
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
UA62784, a novel inhibitor of centromere protein E kinesin-like protein
Meredith C. Henderson; Yeng-Jeng Y. Shaw; Hong Wang; Haiyong Han; Laurence H. Hurley; Gary Flynn; Robert T. Dorr; Daniel D. Von Hoff
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells
Leslie A. Parsels; Meredith A. Morgan; Daria M. Tanska; Joshua D. Parsels; Brian D. Palmer; R. John Booth; William A. Denny; Christine E. Canman; Alan J. Kraker; Theodore S. Lawrence; Jonathan Maybaum
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis
Tibor Schomber; Adrian Zumsteg; Karin Strittmatter; Ivana Crnic; Helena Antoniadis; Amanda Littlewood-Evans; Jeanette Wood; Gerhard Christofori
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer
James Greenaway; Jack Henkin; Jack Lawler; Roger Moorehead; Jim Petrik
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models
Kenneth Kolinsky; Ben-Quan Shen; Yu-E Zhang; Joseph Kohles; Ute Dugan; Thomas F. Zioncheck; David Heimbrook; Kathryn Packman; Brian Higgins
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal–regulated kinase inhibitors and rapamycin
Patrick Frost; Yijiang Shi; Bao Hoang; Joseph Gera; Alan Lichtenstein
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity
Nathan T. Ihle; Robert Lemos; David Schwartz; Junghwan Oh; Robert J. Halter; Peter Wipf; Lynn Kirkpatrick; Garth Powis
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung
Jun Qian; Yong Zou; Jamshedur S.M. Rahman; Bo Lu; Pierre P. Massion
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Rosiglitazone inhibits α4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor γ-independent signals
Xiaojuan Sun; Jeffrey D. Ritzenthaler; Ying Zheng; Jesse Roman; ShouWei Han
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice
Tadaaki Yamada; Hiroaki Muguruma; Seiji Yano; Kenji Ikuta; Hirokazu Ogino; Soji Kakiuchi; Masaki Hanibuchi; Hisanori Uehara; Yasuhiko Nishioka; Saburo Sone
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor
Kazufumi Sakurama; Kazuhiro Noma; Munenori Takaoka; Yasuko Tomono; Nobuyuki Watanabe; Shinji Hatakeyama; Osamu Ohmori; Seiichi Hirota; Takayuki Motoki; Yasuhiro Shirakawa; Tomoki Yamatsuji; Minoru Haisa; Junji Matsuoka; Noriaki Tanaka; Yoshio Naomoto
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
PP2A regulates ionizing radiation–induced apoptosis through Ser46 phosphorylation of p53
Jun Mi; Elzbieta Bolesta; David L. Brautigan; James M. Larner
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68
Yong A. Yu; Charles Galanis; Yanghee Woo; Nanhai Chen; Qian Zhang; Yuman Fong; Aladar A. Szalay
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor
Hung Huynh; Jonathan W.J. Lee; Pierce K.H. Chow; Van Chanh Ngo; Guo Bin Lew; Irene W.L. Lam; Hock Soo Ong; Alexander Chung; Khee Chee Soo
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells
Helen M. Pettersson; Alexander Pietras; Matilda Munksgaard Persson; Jenny Karlsson; Leif Johansson; Maria C. Shoshan; Sven Påhlman
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Telomerase-specific virotherapy in an animal model of human head and neck cancer
Oumi Nakajima; Atsuko Matsunaga; Daiju Ichimaru; Yasuo Urata; Toshiyoshi Fujiwara; Koji Kawakami
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth
Shailesh Singh; Vincent C. Bond; Michael Powell; Udai P. Singh; Harvey L. Bumpers; William E. Grizzle; James W. Lillard, Jr.
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer
Sepideh Afshar; Tsuneaki Asai; Sherie L. Morrison
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Pharmacogenomic approach for the identification of novel determinants of acquired resistance to oxaliplatin in colorectal cancer
Anna Martinez-Cardús; Eva Martinez-Balibrea; Eva Bandrés; Raquel Malumbres; Alba Ginés; José Luís Manzano; Miquel Taron; Jesús Garcia-Foncillas; Albert Abad
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
Ananya Choudhury; Helen Zhao; Farid Jalali; Shahnaz AL Rashid; Jane Ran; Stephane Supiot; Anne E. Kiltie; Robert G. Bristow
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation
David T. Coleman; Rebecca Bigelow; James A. Cardelli
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation
Maria Rius; Carlo Stresemann; Daniela Keller; Manuela Brom; Esther Schirrmacher; Dietrich Keppler; Frank Lyko
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies
Mikako Ogawa; Celeste A.S. Regino; Peter L. Choyke; Hisataka Kobayashi
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
Christophe Marchand; Wendy A. Lea; Ajit Jadhav; Thomas S. Dexheimer; Christopher P. Austin; James Inglese; Yves Pommier; Anton Simeonov
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets
James M. Flanagan; Juan M. Funes; Stephen Henderson; Laurence Wild; Nessa Carey; Chris Boshoff
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells
Molykutty John-Aryankalayil; Sanjeewani T. Palayoor; David Cerna; Michael T. Falduto; Scott R. Magnuson; C. Norman Coleman
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Correction

Effects of IRC-083927 on human tumor growth
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Advertisement

Latest News
Expanding the Targeted Protein Degradation Arsenal
AI Model Could Make Cachexia Detection Easier
Drugging WRN: Clinical Proof-of-Concept Established
View more recent articles
Breaking
23andMe Acquired for Fraction of One-Time Value
Retifanlimab Approved for Anal Cancer
ADC for Lung Cancer Approved
View more recent articles
Research Watch
Frequent Blood Donation Influences DNMT3A-Driven Clonal Hematopoiesis
A Single-Cell Atlas Reveals Characteristics of Pan-Cancer Brain Metastases
BRCA2 Mitigates PARP1 Retention at DNA Repair Sites to Stabilize RAD51
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck.  None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1538-8514
  • Print ISSN 1535-7163

AACR Journals

 

 

  • Copyright © 2025 by the American Association for Cancer Research.
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept