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1 September 2008
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Cover Image
Cover Image
PKD1 (green), β-catenin (red), and p230 (blue) expression and co-localization in Bryostatin 1 treated C4-2-PKD1-GFP prostate cancer cells. Bryostatin 1 treated C4-2-PKD1-GFP cells were transfected with a PKD1 silencing or nontargeted siRNA and stained for β-catenin and p230 antibodies. Confocal images show co-expression and co-localization of PKD1 (green), β-catenin (red), and p230 (blue). In nontargeted siRNA treated cells β-catenin shows strong membrane localization and perinuclear localization in control siRNA transfected cells (left). However, inhibition of PKD1-GFP expression through PKD1 targeted siRNA resulted into punctuate membrane staining and loss of perinuclear β-catenin staining (right). For details, see Jaggi et al., in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Review
Research Articles: Therapeutics, Targets, and Development
Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
Yonglei Shang; Yifan Mao; Jennifer Batson; Suzie J. Scales; Gail Phillips; Mark R. Lackner; Klara Totpal; Simon Williams; Jihong Yang; Zhijun Tang; Zora Modrusan; Christine Tan; Wei-Ching Liang; Siao Ping Tsai; Alexander Vanderbilt; Kenji Kozuka; Klaus Hoeflich; Janet Tien; Sarajane Ross; Congfen Li; Sang Hoon Lee; An Song; Yan Wu; Jean-Philippe Stephan; Avi Ashkenazi; Jiping Zha
Discovery of a novel class of AKT pleckstrin homology domain inhibitors
Daruka Mahadevan; Garth Powis; Eugene A. Mash; Benjamin George; Vijay M. Gokhale; Shuxing Zhang; Kishore Shakalya; Lei Du-Cuny; Margareta Berggren; M. Ahad Ali; Umasish Jana; Nathan Ihle; Sylvestor Moses; Chloe Franklin; Satya Narayan; Nikhil Shirahatti; Emmanuelle J. Meuillet
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95
Margaret A. Park; Guo Zhang; Clint Mitchell; Mohamed Rahmani; Hossein Hamed; Michael P. Hagan; Adly Yacoub; David T. Curiel; Paul B. Fisher; Steven Grant; Paul Dent
Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-κB-dependent mechanism
Matthew B. Rettig; David Heber; Jiabin An; Navindra P. Seeram; Jian Y. Rao; Huiren Liu; Tobias Klatte; Arie Belldegrun; Aune Moro; Susanne M. Henning; Deqiong Mo; William J. Aronson; Allan Pantuck
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
Georg Feldmann; Volker Fendrich; Karen McGovern; Djahida Bedja; Savita Bisht; Hector Alvarez; Jan-Bart M. Koorstra; Nils Habbe; Collins Karikari; Michael Mullendore; Kathleen L. Gabrielson; Rajni Sharma; William Matsui; Anirban Maitra
Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
Kiyoshi Yamaguchi; Maria Cekanova; Michael F. McEntee; Joo-Heon Yoon; Susan M. Fischer; Ingrid B. Renes; Isabelle Van Seuningen; Seung Joon Baek
Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention
Ching-Chi Chiu; Chien-Yu Lin; Li-Yu Lee; Yin-Ju Chen; Ting-Fang Kuo; Joseph Tung-Chieh Chang; Chun-Ta Liao; Hung-Ming Wang; Tzu-Chen Yen; Chia-Rui Shen; Shuen-Kuei Liao; Ann-Joy Cheng
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E–mutated melanomas
Keiran S.M. Smalley; Mercedes Lioni; Maurizia Dalla Palma; Min Xiao; Brijal Desai; Suzanne Egyhazi; Johan Hansson; Hong Wu; Alastair J. King; Patricia Van Belle; David E. Elder; Keith T. Flaherty; Meenhard Herlyn; Katherine L. Nathanson
Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis
Asfar Sohail Azmi; Zhiwei Wang; Ravshan Burikhanov; Vivek M. Rangnekar; Guoping Wang; Jianyong Chen; Shaomeng Wang; Fazlul H. Sarkar; Ramzi M. Mohammad
Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer
Eri Kawata; Eishi Ashihara; Shinya Kimura; Kazumasa Takenaka; Kiyoshi Sato; Ruriko Tanaka; Asumi Yokota; Yuri Kamitsuji; Miki Takeuchi; Junya Kuroda; Fumihiro Tanaka; Toshikazu Yoshikawa; Taira Maekawa
Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index
Charlotte F. McDonagh; Kristine M. Kim; Eileen Turcott; Lindsay L. Brown; Lori Westendorf; Tiffany Feist; Django Sussman; Ivan Stone; Martha Anderson; Jamie Miyamoto; Robert Lyon; Stephen C. Alley; Hans-Peter Gerber; Paul J. Carter
Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity
Claudia Valli; Gabriela Paroni; Angela Maria Di Francesco; Riccardo Riccardi; Michele Tavecchio; Eugenio Erba; Andrea Boldetti; Maurizio Gianni'; Maddalena Fratelli; Claudio Pisano; Lucio Merlini; Antonio Antoccia; Chiara Cenciarelli; Mineko Terao; Enrico Garattini
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
Sonya D. Zabludoff; Chun Deng; Michael R. Grondine; Adam M. Sheehy; Susan Ashwell; Benjamin L. Caleb; Stephen Green; Heather R. Haye; Candice L. Horn; James W. Janetka; Dongfang Liu; Elizabeth Mouchet; Shannon Ready; Judith L. Rosenthal; Christophe Queva; Gary K. Schwartz; Karen J. Taylor; Archie N. Tse; Graeme E. Walker; Anne M. White
N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing
Hongtao Wang; Barry J. Maurer; Yong-Yu Liu; Elaine Wang; Jeremy C. Allegood; Samuel Kelly; Holly Symolon; Ying Liu; Alfred H. Merrill,, Jr.; Valérie Gouazé-Andersson; Jing Yuan Yu; Armando E. Giuliano; Myles C. Cabot
A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance
Julia S. Samaddar; Virgil T. Gaddy; Jennifer Duplantier; Sudharsan Periyasamy Thandavan; Manish Shah; Marlena J. Smith; Darren Browning; Jim Rawson; Sylvia B. Smith; John T. Barrett; Patricia V. Schoenlein
Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer
Yoganand Balagurunathan; David L. Morse; Galen Hostetter; Vijayalakshmi Shanmugam; Phillip Stafford; Sonsoles Shack; John Pearson; Maria Trissal; Michael J. Demeure; Daniel D. Von Hoff; Victor J. Hruby; Robert J. Gillies; Haiyong Han
Correction
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