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1 April 2008
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Cover Image
Cover Image
(A) Tumor spheroids isolated from eGFP mice exposed to CM-DiI-labeled liposomes or PBS show eGFP-expressing stromal cells (green fluorescence), cells that have endocytosed CM-DiI-labeled liposomes (red fluorescence), and a subpopulation of host stromal cells that uptake liposomes (yellow or orange fluorescence, arrows). (B) Tumor spheroids from C57Bl/6 mice exposed to CM-DiI-labeled liposomes or PBS and labeled for expression of the macrophage marker CD68 (green fluorescence) show colocalization of CM-DiI andCD68 (yellow or orange fluorescence, arrows). (C) Spheroids exposed as described in (B) and labeled for the dendritic cell marker CD11c (green fluorescence, arrows) show no colocalization. D. CM-DiI-labeled or unlabeled macrophages were treated with CLIP or PLIP and the conditioned medium was transferred to cultures of mesothelioma cells. Cells incubated in conditioned medium from CM-DiI-labeled CLIP-treated macrophages (left, arrows); cells incubated in conditioned medium from CM-DiI-labeled, PLIP-treated macrophages (middle) or unlabeled, CLIP-treated macrophages (right). All cells were counterstained with DAPI (blue nuclear fluorescence). For details, see Miselis et al. in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Spotlight on Clinical Response
Review
Research Articles: Therapeutics, Targets, and Development
Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-κB, p53, bax, and p27 levels
Catherine A. Tucker; Anita I. Kapanen; Ghania Chikh; Brad G. Hoffman; Alastair H. Kyle; Ian M. Wilson; Dana Masin; Randy D. Gascoyne; Marcel Bally; Richard J. Klasa
MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
Marielle Fournel; Claire Bonfils; Yu Hou; Pu Theresa Yan; Marie-Claude Trachy-Bourget; Ann Kalita; Jianhong Liu; Ai-Hua Lu; Nancy Z. Zhou; Marie-France Robert; Jeffrey Gillespie; James J. Wang; Hélène Ste-Croix; Jubrail Rahil; Sylvain Lefebvre; Oscar Moradei; Daniel Delorme; A. Robert MacLeod; Jeffrey M. Besterman; Zuomei Li
Sensitizing estrogen receptor–negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor
Shu-Chuan Weng; Yoko Kashida; Samuel K. Kulp; Dasheng Wang; Robert W. Brueggemeier; Charles L. Shapiro; Ching-Shih Chen
Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy
Cathy Zhang; Karen Lundgren; Zhengming Yan; Maria E. Arango; Sharon Price; Andrea Huber; Joseph Higgins; Gabriel Troche; Judith Skaptason; Tatiana Koudriakova; Jim Nonomiya; Michelle Yang; Patrick O'Connor; Steve Bender; Gerrit Los; Cristina Lewis; Bart Jessen
Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma
Jack S. Chen; Linda J. Zhou; Michal Entin-Meer; Xiaodong Yang; Mila Donker; Zachary A. Knight; William Weiss; Kevan M. Shokat; Daphne Haas-Kogan; David Stokoe
Antitumor activity of fibroblast growth factor receptor 3–specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis
Jorge L. Martínez-Torrecuadrada; Lawrence H. Cheung; Paula López-Serra; Rodrigo Barderas; Marta Cañamero; Sergio Ferreiro; Michael G. Rosenblum; J. Ignacio Casal
Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells
Maria Serova; Aïda Ghoul; Karim A. Benhadji; Sandrine Faivre; Christophe Le Tourneau; Esteban Cvitkovic; Francois Lokiec; Janet Lord; Steven M. Ogbourne; Fabien Calvo; Eric Raymond
A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras
Yanan Yang; Marie Wislez; Nobukazu Fujimoto; Ludmila Prudkin; Julie G. Izzo; Futoshi Uno; Lin Ji; Amy E. Hanna; Robert R. Langley; Diane Liu; Faye M. Johnson; Ignacio Wistuba; Jonathan M. Kurie
Correction
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