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Volume 7, Issue 3
1 March 2008
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    Tumor antigens are often also expressed by normal cells; therefore, tumor antigen specific immunotherapy could cause destruction of normal tissues. Modulation of immune responses using inducible gene therapy vectors allows tightly regulating these functions to reduce the risk of auto-immunity development. For details, see Curtin et al. in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Review

Turning the gene tap off; implications of regulating gene expression for cancer therapeutics
James F. Curtin; Marianela Candolfi; Weidong Xiong; Pedro R. Lowenstein; Maria G. Castro
View articletitled, Turning the gene tap off; implications of regulating gene expression for cancer therapeutics
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Research Articles: Therapeutics, Targets, and Development

Level of HER-2/neu protein expression in breast cancer may affect the development of endogenous HER-2/neu-specific immunity
Vivian Goodell; James Waisman; Lupe G. Salazar; Corazon dela Rosa; John Link; Andrew L. Coveler; Jennifer S. Childs; Patricia A. Fintak; Doreen M. Higgins; Mary L. Disis
View articletitled, Level of HER-2/<em>neu</em> protein expression in breast cancer may affect the development of endogenous HER-2/<em>neu</em>-specific immunity
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Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity
Jeffrey Cummings; Cassandra Hodgkinson; Rajesh Odedra; Patrizia Sini; Simon P. Heaton; Kirsten E. Mundt; Tim H. Ward; Robert W. Wilkinson; Jim Growcott; Andrew Hughes; Caroline Dive
View articletitled, Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity
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Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells
Michael Sun; Zeev Estrov; Yuan Ji; Kevin R. Coombes; David H. Harris; Razelle Kurzrock
View articletitled, Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells
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Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90
Agustín Hernández; Guillermo López-Lluch; Juan A. Bernal; Plácido Navas; José A. Pintor-Toro
View articletitled, Dicoumarol down-regulates human <em>PTTG1/Securin</em> mRNA expression through inhibition of Hsp90
Supplementary data
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Mitochondrial regulation by c-Myc and hypoxia-inducible factor-1α controls sensitivity to econazole
Yongmao Yu; Maryam Niapour; Yicheng Zhang; Stuart A. Berger
View articletitled, Mitochondrial regulation by c-Myc and hypoxia-inducible factor-1α controls sensitivity to econazole
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A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker
Shelby Crawford; Daniel Belajic; Jianmei Wei; Jason P. Riley; Paul J. Dunford; Scott Bembenek; Anne Fourie; James P. Edwards; Lars Karlsson; Anders Brunmark; Ronald L. Wolin; Jonathan M. Blevitt
View articletitled, A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker
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Ellipticine derivative NSC 338258 represents a potential new antineoplastic agent for the treatment of multiple myeloma
Erming Tian; Terry H. Landowski; Owen W. Stephens; Shmuel Yaccoby; Bart Barlogie; John D. Shaughnessy, Jr.
View articletitled, Ellipticine derivative NSC 338258 represents a potential new antineoplastic agent for the treatment of multiple myeloma
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Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo
Danijela Maksimovic-Ivanic; Sanja Mijatovic; Ljubica Harhaji; Djordje Miljkovic; Darrin Dabideen; Kai Fan Cheng; Katia Mangano; Graziella Malaponte; Yousef Al-Abed; Massimo Libra; Gianni Garotta; Ferdinando Nicoletti; Stanislava Stosic-Grujicic
View articletitled, Anticancer properties of the novel nitric oxide-donating compound (<em>S,R</em>)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide <em>in vitro</em> and <em>in vivo</em>
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A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities
Shlomo Handeli; Julian A. Simon
View articletitled, A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities
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p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR
Manman Gong; Lin Meng; Beihai Jiang; Jianzhi Zhang; Hua Yang; Jian Wu; Chengchao Shou
View articletitled, p37 from <em>Mycoplasma hyorhinis</em> promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR
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Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L–like proteases in tumor microenvironment
Roberta E. Burden; Philip Snoddy; Richard J. Buick; James A. Johnston; Brian Walker; Christopher J. Scott
View articletitled, Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L–like proteases in tumor microenvironment
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Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation
Charlene K. Mason; Suzanne McFarlane; Patrick G. Johnston; Paul Crowe; Pauline J. Erwin; Mathias M. Domostoj; F. Charles Campbell; Soraya Manaviazar; Karl J. Hale; Mohamed El-Tanani
View articletitled, Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation
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Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue
Sung Hee Hwang; Antonina Rait; Kathleen F. Pirollo; Qi Zhou; Venkata Mahidhar Yenugonda; Gary M. Chinigo; Milton L. Brown; Esther H. Chang
View articletitled, Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue
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Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies
Feng An; Daryl C. Drummond; Shannon Wilson; Dmitri B. Kirpotin; Stephen L. Nishimura; V. Courtney Broaddus; Bin Liu
View articletitled, Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies
Supplementary data
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Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery
Albert Lo; Chin-Tarng Lin; Han-Chung Wu
View articletitled, Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery
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Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice
Denis Alferez; Robert W. Wilkinson; Jim Watkins; Richard Poulsom; Nikki Mandir; Stephen R. Wedge; Ian T. Pyrah; Neil R. Smith; Lynsay Jackson; Anderson J. Ryan; Robert A. Goodlad
View articletitled, Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in <em>Apc</em><sup>Min/+</sup> mice
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Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase
Takafumi Okabe; Isamu Okamoto; Sayaka Tsukioka; Junji Uchida; Tsutomu Iwasa; Takeshi Yoshida; Erina Hatashita; Yuki Yamada; Taroh Satoh; Kenji Tamura; Masahiro Fukuoka; Kazuhiko Nakagawa
View articletitled, Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase
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Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells
Hwang-Phill Kim; Sae-Won Han; Sung-Hak Kim; Seock-Ah Im; Do-Youn Oh; Yung-Jue Bang; Tae-You Kim
View articletitled, Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells
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Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo
Hossein Hamed; William Hawkins; Clint Mitchell; Donna Gilfor; Guo Zhang; Xin-Yan Pei; Yun Dai; Michael P. Hagan; John D. Roberts; Adly Yacoub; Steven Grant; Paul Dent
View articletitled, Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death <em>in vitro</em> and <em>in vivo</em>
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Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer
Vessela Vassileva; Christine J. Allen; Micheline Piquette-Miller
View articletitled, Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer
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Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model
Berta Laquente; Cristina Lacasa; Mireia M. Ginestà; Oriol Casanovas; Agnès Figueras; Maica Galán; Ignacio García Ribas; Josep Ramon Germà; Gabriel Capellà; Francesc Viñals
View articletitled, Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model
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Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma
Yan Ding; Elissa A. Boguslawski; Bree D. Berghuis; John J. Young; Zhongfa Zhang; Kim Hardy; Kyle Furge; Eric Kort; Arthur E. Frankel; Rick V. Hay; James H. Resau; Nicholas S. Duesbery
View articletitled, Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma
Supplementary data
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Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation
Daniel E. Frigo; Donald P. McDonnell
View articletitled, Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation
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Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells
Rosaline C-Y. Hui; Richard E. Francis; Stephanie K. Guest; Joana R. Costa; Ana R. Gomes; Stephen S. Myatt; Jan J. Brosens; Eric W-F. Lam
View articletitled, Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene <em>ABCB1</em> (<em>MDR1</em>) in K562 leukemic cells
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Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds
Valentina Benedetti; Paola Perego; Giovanni Luca Beretta; Elisabetta Corna; Stella Tinelli; Sabina Carla Righetti; Roberto Leone; Piero Apostoli; Cinzia Lanzi; Franco Zunino
View articletitled, Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds
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Modulation of drug resistance by artificial transcription factors
Pilar Blancafort; Mario P. Tschan; Sharon Bergquist; Daniel Guthy; Arndt Brachat; Dennis A. Sheeter; Bruce E. Torbett; Dirk Erdmann; Carlos F. Barbas, III
View articletitled, Modulation of drug resistance by artificial transcription factors
Supplementary data
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Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells
Zhong Chen; Robert F. Place; Zhe-Jun Jia; Deepa Pookot; Rajvir Dahiya; Long-Cheng Li
View articletitled, Antitumor effect of dsRNA-induced p21<sup>WAF1/CIP1</sup> gene activation in human bladder cancer cells
Supplementary data
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Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice
Yuji Takei; Yasushi Saga; Hiroaki Mizukami; Takeshi Takayama; Michitaka Ohwada; Keiya Ozawa; Mitsuaki Suzuki
View articletitled, Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice
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Blockade of viral interleukin-6 expression of Kaposi's sarcoma–associated herpesvirus
Yan-Jin Zhang; Rheba S. Bonaparte; Deendayal Patel; David A. Stein; Patrick L. Iversen
View articletitled, Blockade of viral interleukin-6 expression of Kaposi's sarcoma–associated herpesvirus
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A chaperone protein-enriched tumor cell lysate vaccine generates protective humoral immunity in a mouse breast cancer model
Gang Li; Samita Andreansky; Gustavo Helguera; Marjan Sepassi; Nona Janikashvili; Jessica Cantrell; Collin L. LaCasse; Nicolas Larmonier; Manuel L. Penichet; Emmanuel Katsanis
View articletitled, A chaperone protein-enriched tumor cell lysate vaccine generates protective humoral immunity in a mouse breast cancer model
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Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias
Florencia Cano; Richard Pannel; George A. Follows; Terence H. Rabbitts
View articletitled, Preclinical modeling of cytosine arabinoside response in <em>Mll-Enl</em> translocator mouse leukemias
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