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1 February 2007
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Cover Image
Cover Image
Human plasminogen kringle 5 protein acts as a potent antiangiogenic and pro-inflammatory agent. Murine DA/3 mammary adenocarcinoma cells (left), gene-engineered green fluorescent protein (GFP)-expressing DA/3 cells (middle), and gene-engineered kringle5-GFP-expressing DA/3 cells (right) were embedded in Matrigel and implanted subcutaneously in immune competent BALB/c mice. Representative images of retrieved implants (arrows) 1 week postimplantation are demonstrated. For details, see Perri et al. in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Spotlight on Molecular Profiling
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells
William C. Reinhold; Mark A. Reimers; Alika K. Maunakea; Sohyoung Kim; Samir Lababidi; Uwe Scherf; Uma T. Shankavaram; Micah S. Ziegler; Claudia Stewart; Hosein Kouros-Mehr; Hengmi Cui; Douglas Dolginow; Dominic A. Scudiero; Yves G. Pommier; David J. Munroe; Andrew P. Feinberg; John N. Weinstein
Reviews
Research Articles: Therapeutics, Targets, and Development
Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade
Wenjuan Wu; Amir Onn; Takeshi Isobe; Satoshi Itasaka; Robert R. Langley; Tomoaki Shitani; Keiko Shibuya; Ritsuko Komaki; Anderson J. Ryan; Isaiah J. Fidler; Roy S. Herbst; Michael S. O'Reilly
Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays
Belen Rubio-Viqueira; Heather Mezzadra; Matthew E. Nielsen; Antonio Jimeno; Xianfeng Zhang; Christine Iacobuzio-Donahue; Anirban Maitra; Manuel Hidalgo; Soner Altiok
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
Elizabeth Buck; Alexandra Eyzaguirre; Sharon Barr; Stuart Thompson; Regina Sennello; David Young; Kenneth K. Iwata; Neil W. Gibson; Pablo Cagnoni; John D. Haley
17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines
Clint Mitchell; Margaret A. Park; Guo Zhang; Song Iy Han; Hisashi Harada; Richard A. Franklin; Adly Yacoub; Pin-Lan Li; Philip B. Hylemon; Steven Grant; Paul Dent
Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor κB
Dong Ju Son; Mi Hee Park; Sang Jin Chae; Soon Ok Moon; Jae Woong Lee; Ho Sueb Song; Dong Cheul Moon; Sang Sun Kang; Young Ee Kwon; Jin Tae Hong
Treatment of prostate cancer with Ad5/3Δ24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo
Maria Rajecki; Anna Kanerva; Ulf-Håkan Stenman; Mikko Tenhunen; Lotta Kangasniemi; Merja Särkioja; Martti Y. Ala-Opas; Henrik Alfthan; Anna Sankila; Erkki Rintala; Renee A. Desmond; Tanja Hakkarainen; Akseli Hemminki
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