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1 October 2007
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Proapoptotic synergy between the antiestrogen, 4-hydroxytamoxifen (4-OHT) and the plant toxin, persin is mediated via an upregulation of Bim mRNA in human breast cancer cells. A combination of nontoxic concentrations of persin (2.76 μmol/L) or 4-OHT (7.5 μmol/L) leads to a significant enhancement of apoptosis compared to single agent treatment, and this is associated with the increase in Bim mRNA shown. Knock-down of Bim expression with specific siRNA abrogates this synergistic response. For details, see Roberts et al. in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514
Review
Research Articles: Therapeutics, Targets, and Development
Expression of epidermal growth factor (EGF)/transforming growth factor-α by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice
Wenjuan Wu; Michael S. O'Reilly; Robert R. Langley; Rachel Z. Tsan; Cheryl H. Baker; Neby Bekele; Xi Ming Tang; Amir Onn; Isaiah J. Fidler; Roy S. Herbst
Response to trastuzumab, erlotinib, and bevacizumab, alone and in combination, is correlated with the level of human epidermal growth factor receptor-2 expression in human breast cancer cell lines
David R. Emlet; Kathryn A. Brown; Deborah L. Kociban; Agnese A. Pollice; Charles A. Smith; Ben Brian L. Ong; Stanley E. Shackney
Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization–independent activation of the nuclear factor-κB/IκB kinase signal pathway
Seung Ho Lee; Seung Mo Son; Dong Ju Son; Sun Mi Kim; Tack Joong Kim; Sukgil Song; Dong Cheul Moon; Hyo Won Lee; Jae Chun Ryu; Do-Young Yoon; Jin Tae Hong
Correction
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