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Volume 5, Issue 6
1 June 2006
Molecular Cancer Therapeutics Cover Image for Volume 5, Issue 6
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    Cover Image

    Issue cover image
    Subcellular colocalization of an anti-p97 antibody-drug conjugate with a lysosomal marker in melanoma cells. SK-MEL-5 cells were treated with the anti-p97 antibody-auristatin conjugate, L49-vcMMAF, directly labeled with Alexa Fluor 594 for 48 hours. L49-vcMMAF (red) and the lysosomal marker CD107a (green) colocalize (yellow) in melanoma cells that are effectively killed by L49-vcMMAF. Chromosomal DNA is stained with DAPI (blue). For antibody-drug conjugates targeting p97, both antigen level and trafficking to the lysosomes are important factors for achieving robust in vitro cytotoxicity against cancer cells. For details, see Smith et al. in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1535-7163
EISSN 1538-8514

Editorial

Is p21 an oncogene?
Andrei L. Gartel
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Reviews

Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer
Elisa Giovannetti; Valentina Mey; Sara Nannizzi; Giuseppe Pasqualetti; Mario Del Tacca; Romano Danesi
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BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions
Ronit I. Yarden; Moshe Z. Papa
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Research Articles: Targets

Roles of nonhomologous end-joining pathways in surviving topoisomerase II–mediated DNA damage
Mobeen Malik; Karin C. Nitiss; Vanessa Enriquez-Rios; John L. Nitiss
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Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1α activity and vascular endothelial growth factor expression in small cell lung cancer cells
Julie Litz; Geoffrey W. Krystal
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Therapeutic potential of antisense oligodeoxynucleotides to down-regulate thymidylate synthase in mesothelioma
Janet Flynn; Randal W. Berg; Tracy Wong; Marijke van Aken; Mark D. Vincent; Masakazu Fukushima; James Koropatnick
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Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression
Haruyo Ichikawa; Yasunari Takada; Shishir Shishodia; Bolleddula Jayaprakasam; Muraleedharan G. Nair; Bharat B. Aggarwal
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Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression
Béatrix Bugler; Muriel Quaranta; Bernadette Aressy; Marie-Christine Brezak; Grégoire Prevost; Bernard Ducommun
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The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells
Yan Ji; Hong Jin Lee; Catherine Goodman; Milan Uskokovic; Karen Liby; Michael Sporn; Nanjoo Suh
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β-Escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21waf1/cip1 in colon cancer cells
Jagan M.R. Patlolla; Jayadev Raju; Malisetty V. Swamy; Chinthalapally V. Rao
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Functional analysis and molecular modeling show a preserved wild-type activity of p53C238Y
Marco Ferrone; Federica Perrone; Elena Tamborini; Maria Silvia Paneni; Maurizio Fermeglia; Simona Suardi; Elisa Pastore; Domenico Delia; Marco A. Pierotti; Sabrina Pricl; Silvana Pilotti
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Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97
Leia M. Smith; Albina Nesterova; Stephen C. Alley; Michael Y. Torgov; Paul J. Carter
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Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma
Francesca Spinella; Laura Rosanò; Valeriana Di Castro; Samantha Decandia; Adriana Albini; Maria Rita Nicotra; Pier Giorgio Natali; Anna Bagnato
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Implications of tissue transglutaminase expression in malignant melanoma
Jansina Y. Fok; Suhendan Ekmekcioglu; Kapil Mehta
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Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells
Lorena de la Peña; William E. Burgan; Donna J. Carter; Melinda G. Hollingshead; Merriline Satyamitra; Kevin Camphausen; Philip J. Tofilon
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Research Articles: Therapeutics

PM-20, a novel inhibitor of Cdc25A, induces extracellular signal–regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo
Siddhartha Kar; Meifang Wang; Wei Yao; Christopher J. Michejda; Brian I. Carr
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Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells
Daniel Dindo; Felix Dahm; Zdzislaw Szulc; Alicja Bielawska; Lina M. Obeid; Yusuf A. Hannun; Rolf Graf; Pierre-Alain Clavien
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Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets
Chinthalapally V. Rao; Bandaru S. Reddy; Vernon E. Steele; C-X Wang; Xiaoping Liu; Nengtai Ouyang; Jagan M.R. Patlolla; Barbara Simi; Levy Kopelovich; Basil Rigas
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Fulvestrant (ICI 182,780) down-regulates androgen receptor expression and diminishes androgenic responses in LNCaP human prostate cancer cells
Rumi S. Bhattacharyya; Aruna V. Krishnan; Srilatha Swami; David Feldman
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A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments
Gregory Z. Ferl; Vania Kenanova; Anna M. Wu; Joseph J. DiStefano, III
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Supplementary data
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Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways
Maria Nyåkern; Alessandra Cappellini; Irina Mantovani; Alberto M. Martelli
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Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics
Kristen A. Kellar; Matthew V. Lorenzi; Ching Ping Ho; Dan You; Mei-Li Wen; Rolf P. Ryseck; Simone Oppenheimer; Brian E. Fink; Gregory D. Vite; Bruce R. Rowley; Chiang Yu; David K. Bol; Francis Y. Lee; Tai W. Wong
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Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy
K. Jin Yoon; Jianjun Qi; Joanna S. Remack; Kristopher G. Virga; M. Jason Hatfield; Philip M. Potter; Richard E. Lee; Mary K. Danks
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Chemotherapy and chemosensitization of non–small cell lung cancer with a novel immunomodulatory oligonucleotide targeting Toll-like receptor 9
Hui Wang; Elizabeth R. Rayburn; Wei Wang; Ekambar R. Kandimalla; Sudhir Agrawal; Ruiwen Zhang
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B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells
Rita Nahta; Linda X.H. Yuan; Derek J. Fiterman; Li Zhang; W. Fraser Symmans; Naoto T. Ueno; Francisco J. Esteva
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Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling
Stéphanie Arnould; Victoria J. Spanswick; Janet S. Macpherson; John A. Hartley; David E. Thurston; Duncan I. Jodrell; Sylvie M. Guichard
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Suicide cancer gene therapy using pore-forming toxin, streptolysin O
Wan Seok Yang; Sue-O Park; A-Rum Yoon; Ji Young Yoo; Min Kyung Kim; Chae-Ok Yun; Chul-Woo Kim
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Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery
Philippe Martinive; Julie De Wever; Caroline Bouzin; Christine Baudelet; Pierre Sonveaux; Vincent Grégoire; Bernard Gallez; Olivier Feron
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Research Articles: Development

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
Nicola F. Smith; Angela Hayes; Karen James; Bernard P. Nutley; Edward McDonald; Alan Henley; Brian Dymock; Martin J. Drysdale; Florence I. Raynaud; Paul Workman
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