Issues
-
Cover Image
Cover Image
On the Cover
Platelet 12-lipoxygenase (P-12-LOX) is overexpressed in different types of cancers and the level of expression is correlated with grade. Arachidonic acid is metabolized by 12-LOX to 12(S)HETE, and this metabolite is involved in cancer progression by modulating cell proliferation in multiple cancer related pathways inducing angiogenesis and metastasis. Thus, inhibition of P-12-LOX can reduce these two processes. Using a homology model of the three-dimensional structure of human P-12-LOX (green structure), we performed computational docking of curcumin derivatives to identify novel inhibitors (magenta and green stick models in the ribbon model of P-12-LOX). From a set of the curcuminoids that were successfully docked and selected for testing, two were found to inhibit human lipoxygenase better than curcumin. For details, see Jankun et al. in this issue. - PDF Icon PDF LinkTable of Contents
Reviews
Research Articles: Targets
Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non–small cell lung cancer cells
Research Articles: Therapeutics
Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc
Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus–mediated expression of human endostatin
Activation of membrane androgen receptors potentiates the antiproliferative effects of paclitaxel on human prostate cancer cells
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells
Correction
Advertisement