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Issues

Volume 3, Issue 5
1 May 2004
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ISSN 1535-7163
EISSN 1538-8514
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ARTICLE

Multiparametric evaluation of apoptosis: Effects of standard cytotoxic agents and the cyanoguanidine CHS 828
Henrik Lövborg; Peter Nygren; Rolf Larsson
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The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling
G. Sakuntala Warshamana-Greene; Julie Litz; Elisabeth Buchdunger; Francesco Hofmann; Carlos Garcı́a-Echeverrı́a; Geoffrey W. Krystal
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Photodynamic therapy with indocyanine green complements and enhances low-dose cisplatin cytotoxicity in MCF-7 breast cancer cells
Elvira Crescenzi; Linda Varriale; Mariangela Iovino; Angela Chiaviello; Bianca Maria Veneziani; Giuseppe Palumbo
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Antisense oligonucleotides directed at the bcl-xl gene product augment chemotherapy response in mesothelioma
Mustafa K. Ozvaran; Xiaobo X. Cao; Steven D. Miller; Brett A. Monia; Waun Ki Hong; W. Roy Smythe
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Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity
Edward G. Mimnaugh; Wanping Xu; Michele Vos; Xitong Yuan; Jennifer S. Isaacs; Kheem S. Bisht; David Gius; Len Neckers
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Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells
Dong Xiao; Candace S. Johnson; Donald L. Trump; Shivendra V. Singh
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DNA damage responses triggered by a highly cytotoxic monofunctional DNA alkylator, hedamycin, a pluramycin antitumor antibiotic
Lan Chun Tu; Thomas Melendy; Terry A. Beerman
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The novel estrogen 17α-20Z-21-[(4-amino)phenyl]-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol induces apoptosis in prostate cancer cell lines at nanomolar concentrations in vitro
James A. Mobley; James O. L'Esperance; Mengchu Wu; Carolyn J. Friel; Robert H. Hanson; Shuk-Mei Ho
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Disulfide-constrained peptides that bind to the extracellular portion of the prostate-specific membrane antigen
Shawn E. Lupold; Ronald Rodriguez
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Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription
Sung Dae Cho; Cheng Jiang; Barbara Malewicz; Yan Dong; Charles Y.F. Young; Kyung-Sun Kang; Yong-Soon Lee; Clement Ip; Junxuan Lü
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Different DNA lesions trigger distinct cell death responses in HCT116 colon carcinoma cells
Shaochun Bai; David W. Goodrich
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Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated–dependent and –independent mechanisms
Wai Yi Siu; Anita Lau; Talha Arooz; Jeremy P.H. Chow; Horace T.B. Ho; Randy Y.C. Poon
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Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy
Valerie Gouazé; Jing Y. Yu; Richard J. Bleicher; Tie-Yan Han; Yong-Yu Liu; Hongtao Wang; Michael M. Gottesman; Arie Bitterman; Armando E. Giuliano; Myles C. Cabot
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Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer
Phillip J. Gray, Jr; David J. Bearss; Haiyong Han; Raymond Nagle; Ming-Sound Tsao; Nicholas Dean; Daniel D. Von Hoff
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Minireview

Hypoxia inducible factor-1α as a cancer drug target
Garth Powis; Lynn Kirkpatrick
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