Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 24, Issue 1
1 January 2025
Issue Cover
All Issues
  • Cover Image

    Cover Image

    issue cover
    A lung tumor targeting LNP containing an anti-GSTP siRNA reduces glutathione S-Transferase P, leading to inhibition of downstream pathways of KRAS (AKT, MEK and ERK), which results in decreased cell survival and proliferation. Created in BioRender. Adami, R. (2024) BioRender.com/n51h086. See graphical abstract and the full article on page 7.
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 1535-7163
EISSN 1538-8514

Highlights

Selected Articles from This Issue
View articletitled, Selected Articles from This Issue
Open the PDF for in another window

First Disclosure

A Novel Lipid Nanoparticle NBF-006 Encapsulating Glutathione S-Transferase P siRNA for the Treatment of KRAS-Driven Non–small Cell Lung Cancer
Cima Cina; Bharat Majeti; Zhihong O’Brien; Li Wang; Jean Pierre Clamme; Roger Adami; Kwok Yin Tsang; Jens Harborth; Wenbin Ying; Sonya Zabludoff
View articletitled, A Novel Lipid Nanoparticle NBF-006 Encapsulating Glutathione S-Transferase P siRNA for the Treatment of KRAS-Driven Non–small Cell Lung Cancer
Supplementary data
Open the PDF for in another window

Reviews

Looking Beyond Checkpoint Inhibitor Monotherapy: Uncovering New Frontiers for Pancreatic Cancer Immunotherapy
Eileena F. Giurini; Oliver Ralph; Sam G. Pappas; Kajal H. Gupta
View articletitled, Looking Beyond Checkpoint Inhibitor Monotherapy: Uncovering New Frontiers for Pancreatic Cancer Immunotherapy
Open the PDF for in another window
Advances and Challenges in RAS Signaling Targeted Therapy in Leukemia
Yu Chen; Zhenghao Yin; Kenneth D. Westover; Zhiwei Zhou; Liping Shu
View articletitled, Advances and Challenges in RAS Signaling Targeted Therapy in Leukemia
Supplementary data
Open the PDF for in another window

Small Molecule Therapeutics

The Discovery of a Potent PARP1 Inhibitor Senaparib
Sui X. Cai; Ning Ma; Xiaozhu Wang; Mingchuan Guo; Yangzhen Jiang; Ye E. Tian
View articletitled, The Discovery of a Potent PARP1 Inhibitor Senaparib
Open the PDF for in another window
PARP7 Inhibitors and AHR Agonists Act Synergistically across a Wide Range of Cancer Models
Huadong Chen; Xuxu Gou; Ying Mao; Patrick C. O’Leary; Morgan E. Diolaiti; Alan Ashworth
View articletitled, PARP7 Inhibitors and AHR Agonists Act Synergistically across a Wide Range of Cancer Models
Supplementary data
Open the PDF for in another window
Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells
Jay M. Gamma; Qiang Liu; Erwan Beauchamp; Aishwarya Iyer; Megan C. Yap; Zoulika Zak; Cassidy Ekstrom; Rony Pain; Morris A. Kostiuk; John R. Mackey; Joseph Brandwein; Jean C.Y. Wang; Luc G. Berthiaume
View articletitled, Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells
Supplementary data
Open the PDF for in another window
A Small-Molecule BCL6 Inhibitor as an Anti-Proliferative Agent for Diffuse Large B-Cell Lymphoma
Yajing Xing; Weikai Guo; Min Wu; Jiuqing Xie; Dongxia Huang; Pan Hu; Miaoran Zhou; Lin Zhang; Yadong Zhong; Mingyao Liu; Yihua Chen; Zhengfang Yi
View articletitled, A Small-Molecule BCL6 Inhibitor as an Anti-Proliferative Agent for Diffuse Large B-Cell Lymphoma
Supplementary data
Open the PDF for in another window

Large Molecule Therapeutics

Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia
Richard Harrop; Daniel G. Blount; Naeem Khan; Mayowa Soyombo; Laura Moyce; Mark T. Drayson; Jenny Down; Michelle A. Lawson; Deirdre O’Connor; Rachael Nimmo; Yatish Lad; Bernard Souberbielle; Kyriacos Mitrophanous; Anna Ettorre
View articletitled, Targeting Tumor Antigen 5T4 Using CAR T Cells for the Treatment of Acute Myeloid Leukemia
Supplementary data
Open the PDF for in another window
Tumor-Specific Antigen Delivery for T-cell Therapy via a pH-Sensitive Peptide Conjugate
Annali M. Yurkevicz; Yanfeng Liu; Samuel G. Katz; Peter M. Glazer
View articletitled, Tumor-Specific Antigen Delivery for T-cell Therapy via a pH-Sensitive Peptide Conjugate
Supplementary data
Open the PDF for in another window
Tumor Integrin-Targeted Glucose Oxidase Enzyme Promotes ROS-Mediated Cell Death that Combines with Interferon Alpha Therapy for Tumor Control
Jordan A. Stinson; Allison Sheen; Brianna M. Lax; Grace N. Yang; Lauren Duhamel; Luciano Santollani; Elizabeth Fink; Joseph R. Palmeri; Karl Dane Wittrup
View articletitled, Tumor Integrin-Targeted Glucose Oxidase Enzyme Promotes ROS-Mediated Cell Death that Combines with Interferon Alpha Therapy for Tumor Control
Supplementary data
Open the PDF for in another window

Targeting Drug Resistance

Riluzole Enhancing Anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer
Beiyuan Liang; Misbah Khan; Hayden Storts; Evan H. Zhang; Xinru Zheng; Xuanxuan Xing; Hazel Claybon; Jenna Wilson; Chunjie Li; Ning Jin; Richard Fishel; Wayne O. Miles; Jing J. Wang
View articletitled, Riluzole Enhancing Anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer
Supplementary data
Open the PDF for in another window

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer
Niranjan Meher; Anil P. Bidkar; Anju Wadhwa; Kondapa Naidu Bobba; Suchi Dhrona; Chandrashekhar Dasari; Changhua Mu; Cyril O.Y. Fong; Juan A. Cámara; Umama Ali; Megha Basak; David Bulkley; Veronica Steri; Shaun D. Fontaine; Jun Zhu; Adam Oskowitz; Rahul R. Aggarwal; Renuka Sriram; Jonathan Chou; David M. Wilson; Youngho Seo; Daniel V. Santi; Gary W. Ashley; Henry F. VanBrocklin; Robert R. Flavell
View articletitled, PET Imaging Using <sup>89</sup>Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer
Supplementary data
Open the PDF for in another window

Correction

Correction: Inhibition of the Met Receptor Tyrosine Kinase Signaling Enhances the Chemosensitivity of Glioma Cell Lines to CDDP Through Activation of p38 MAPK Pathway
Xiuqin Lou; Qibing Zhou; Ying Yin; Cheng Zhou; Yan Shen
View articletitled, Correction: Inhibition of the Met Receptor Tyrosine Kinase Signaling Enhances the Chemosensitivity of Glioma Cell Lines to CDDP Through Activation of p38 MAPK Pathway
Open the PDF for in another window

Acknowledgment to Reviewers

Acknowledgement to Reviewers
View articletitled, Acknowledgement to Reviewers
Open the PDF for in another window

Advertisement

Breaking
$500,000 Purse Announced for TBXT Drugs
B7-H4 Inhibitor Effective for Some Triple-Negative Breast Cancers
CAR-Related T-Cell Malignancies Rare, Another Study Finds
View more recent articles
Latest News
Greater Certainty of Survival Valued Over Speedier Drug Access
Keto Diet Key to Fueling CARs?
ADC for Lymphoma Elicits Near-Perfect Response Rate
View more recent articles
Research Watch
Engineered Focal Oncogene Amplifications Drive Transformation and Progression
Glycolysis Dictates Response to Fasting-Mimicking Diet in Breast Cancer
Tumor Suppressor Gene Zygosity Can Predict Therapeutic Response in Cancer
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1538-8514
  • Print ISSN 1535-7163

AACR Journals

 

 

  • Copyright © 2025 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept