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1 November 2024
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M1069 counters adenosine-mediated immunosuppression and tumor promotion through dual antagonism of A2A and A2B adenosine receptors. See graphical abstract and the full article on page 1517. - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
First Disclosures
Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo
Kai Schiemann; Natalya Belousova; Armine Matevossian; Kalyan C. Nallaparaju; Giorgio Kradjian; Meghana Pandya; Zhouxiang Chen; Esengul Aral; Eva-Maria Krauel; Elissaveta Petrova; Carsten Boesler; Thomas Kitzing; Marc Lecomte; Christian Wagner; Anne Laure Blayo; Stephan Schann; Bayard Huck; Jacques Moisan; Rinat Zaynagetdinov
Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Shalom D. Goldberg; Tero Satomaa; Olulanu Aina; Olli Aitio; Krista Burke; Vadim Dudkin; Brian Geist; Onyi Irrechukwu; Anna-Liisa Hänninen; Annamari Heiskanen; Jari Helin; Jukka O. Hiltunen; Jacqueline Kinyamu-Akunda; Donna M. Klein; Neeraj Kohli; Titta Kotiranta; Tuula Lähteenmäki; Ritva Niemelä; Virve Pitkänen; Henna Pynnönen; William Rittase; Kristen Wiley; Junguo Zhou; Juhani Saarinen
Review
Small Molecule Therapeutics
Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment
Suna Erdem; Hyojae James Lee; Jayanth Surya Narayanan Shankara Narayanan; Mohottige Don Neranjan Tharuka; Jorge De la Torre; Tianchen Ren; Yixuan Kuang; Tharindumala Abeywardana; Kevin Li; Allison J. Berger; Andrew M. Lowy; Rebekah R. White; Yuan Chen
Large Molecule Therapeutics
SC134-TCB Targeting Fucosyl-GM1, a T Cell–Engaging Antibody with Potent Antitumor Activity in Preclinical Small Cell Lung Cancer Models
Foram Dave; Poonam Vaghela; Bryony Heath; Zuzana Dunster; Elena Dubinina; Dhruma Thakker; Katie Mann; Joe Chadwick; Gaëlle Cane; Bubacarr G. Kaira; Omar J. Mohammed; Ruhul Choudhury; Samantha Paston; Tina Parsons; Mireille Vankemmelbeke; Lindy Durrant
Targeting Drug Resistance
YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma
Yoko Furutake; Ken Yamaguchi; Koji Yamanoi; Sachiko Kitamura; Shiro Takamatsu; Mana Taki; Masayo Ukita; Yuko Hosoe; Ryusuke Murakami; Kaoru Abiko; Akihito Horie; Junzo Hamanishi; Tsukasa Baba; Noriomi Matsumura; Masaki Mandai
Retraction
Correction
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