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Issues

Volume 22, Issue 9
1 September 2023
Issue Cover
All Issues
ISSN 1535-7163
EISSN 1538-8514

Highlights

Selected Articles from This Issue
View articletitled, Selected Articles from This Issue
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First Disclosures

Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer
Dorin Toader; Shawn P. Fessler; Scott D. Collins; Patrick R. Conlon; Reddy Bollu; Kalli C. Catcott; Chen-Ni Chin; Anouk Dirksen; Bingfan Du; Jeremy R. Duvall; Stacy Higgins; Mariya V. Kozytska; Kamela Bellovoda; Chelsey Faircloth; David Lee; Fu Li; Liuliang Qin; Caitlin Routhier; Pamela Shaw; Cheri A. Stevenson; Jason Wang; Phonphimon Wongthida; Elena Ter-Ovanesyan; Elizabeth Ditty; Stephen P. Bradley; Ling Xu; Mao Yin; Alexandr V. Yurkovetskiy; Rebecca Mosher; Marc Damelin; Timothy B. Lowinger
View articletitled, Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer
Supplementary data
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AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors
Weining Weng; Tao Meng; Junyi Pu; Linjie Ma; Yi Shen; Zhaohui Wang; Rong Pan; Mingqiao Wang; Caiwei Chen; Lijun Wang; Jianjian Zhang; Biao Zhou; Siyuan Shao; Yu Qian; Shuhui Liu; Wenhao Hu; Xun Meng
View articletitled, AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors
Supplementary data
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Review

FOXN Transcription Factors: Regulation and Significant Role in Cancer
Jiali Song; Longshan Li; Yang Fang; Yue Lin; Luojia Wu; Wei Wan; Gen Wei; Fuzhou Hua; Jun Ying
View articletitled, FOXN Transcription Factors: Regulation and Significant Role in Cancer
Supplementary data
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Small Molecule Therapeutics

T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
Vi Lam; Carly Roleder; Tingting Liu; Nur Bruss; Scott Best; Xiaoguang Wang; Tycel Phillips; Geoffrey Shouse; Allison J. Berger; Lapo Alinari; Lili Wang; Tanya Siddiqi; Nathan D. Pennock; Alexey V. Danilov
View articletitled, T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
Supplementary data
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Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model
Rupali Sharma; Bhargav Earla; Kwamena E. Baidoo; Martha A. Zeiger; James P. Madigan; Freddy E. Escorcia; Samira M. Sadowski
View articletitled, Upregulation of Somatostatin Receptor Type 2 Improves <sup>177</sup>Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model
Supplementary data
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Large Molecule Therapeutics

S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
Yoji Nagira; Morio Nagira; Ryohei Nagai; Wataru Nogami; Michinari Hirata; Azumi Ueyama; Tetsuya Yoshida; Mai Yoshikawa; Satomi Shinonome; Hiroshi Yoshida; Miya Haruna; Hiroto Miwa; Natsumi Chatani; Naganari Ohkura; Hisashi Wada; Hidekazu Tanaka
View articletitled, S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
Supplementary data
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A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies
Sabine Zitzmann-Kolbe; Alexander Kristian; Dieter Zopf; Claudia Kamfenkel; Oliver Politz; Christine Ellingsen; Jochen Hilbig; Mark U. Juul; Jesper Fonslet; Carsten H. Nielsen; Christoph A. Schatz; Roger M. Bjerke; Alan S. Cuthbertson; Dominik Mumberg; Urs B. Hagemann
View articletitled, A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies
Supplementary data
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Targeting Drug Resistance

Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma
McKenna Q. Glasheen; Signe Caksa; Amelia G. Young; Nicole A. Wilski; Connor A. Ott; Inna Chervoneva; Keith T. Flaherty; Meenhard Herlyn; Xiaowei Xu; Andrew E. Aplin; Claudia Capparelli
View articletitled, Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma
Supplementary data
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Models and Technologies

Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures
Stephen H. Chang; Ryan J. Ice; Michelle Chen; Maxim Sidorov; Rinette W.L. Woo; Aida Rodriguez-Brotons; Damon Jian; Han Kyul Kim; Angela Kim; David E. Stone; Ari Nazarian; Alyssia Oh; Gregory J. Tranah; Mehdi Nosrati; David de Semir; Altaf A. Dar; Pierre-Yves Desprez; Mohammed Kashani-Sabet; Liliana Soroceanu; Sean D. McAllister
View articletitled, Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures
Supplementary data
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  • Print ISSN 1535-7163

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