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1 April 2023
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Schematic showing the structure of SGN-CD228A, in which the glucuronide linker contributes to increased intracellular retention of the MMAE cytotoxic payload compared to a dipeptide linker. Read the full article on page 421. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1535-7163
EISSN 1538-8514
Highlights
MCT First Disclosures
SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models
Rebecca Mazahreh; Marsha L. Mason; John J. Gosink; Devra J. Olson; Robert Thurman; Christopher Hale; Lori Westendorf; Thomas A. Pires; Christopher I. Leiske; Markus Carlson; Liem T. Nguyen; Julia H. Cochran; Nicole M. Okeley; Roma Yumul; Steven Jin; Ivan J. Stone; Disha Sahetya; Albina Nesterova; Sean Allred; Kelly M. Hensley; Rachael Hu; Robert Lawrence; Timothy S. Lewis; Sharsti Sandall
Review
Small Molecule Therapeutics
Large Molecule Therapeutics
Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors
Ben Umiker; Yasmin Hashambhoy-Ramsay; Jeff Smith; Tanzila Rahman; Amy Mueller; Rachel Davidson; Christina Meyer; Gayatri Patankar; Mohammad Murshid Alam; Sarah Jaffe; Kristin Krukenberg; Allison Goodman; Vikki Spaulding; Michelle Priess; Abha Dhaneshwar; Masie Wong; Alexa Diiorio; Kristin O'Malley; Lara McGrath; Margaret Willer; Lauren Pepper; Monica Gostissa; Katalin Kis-Toth; Dmitri Wiederschain; Heather Cohen; Donald R. Shaffer
Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma
Jordi Abril-Fornaguera; Laura Torrens; Carmen Andreu-Oller; Juan Carrillo-Reixach; Alex Rialdi; Ugne Balaseviciute; Roser Pinyol; Carla Montironi; Philipp K. Haber; Álvaro Del Río-Álvarez; Montserrat Domingo-Sàbat; Laura Royo; Nicholas K. Akers; Catherine E. Willoughby; Judit Peix; Miguel Torres-Martin; Marc Puigvehi; Stefano Cairo; Margaret Childs; Rudolf Maibach; Rita Alaggio; Piotr Czauderna; Bruce Morland; Bojan Losic; Vincenzo Mazzaferro; Ernesto Guccione; Daniela Sia; Carolina Armengol; Josep M. Llovet
A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE)
Elizabeth Pan; Wanling Xie; Archana Ajmera; Arlene Araneta; Christina Jamieson; Edmund Folefac; Arif Hussain; Christos E. Kyriakopoulos; Adam Olson; Mamta Parikh; Rahul Parikh; Biren Saraiya; S. Percy Ivy; Eliezer M. Van Allen; Neal I. Lindeman; Bose S. Kochupurakkal; Geoffrey I. Shapiro; Rana R. McKay
Targeting Drug Resistance
Griseofulvin Radiosensitizes Non–Small Cell Lung Cancer Cells and Activates cGAS
Xing Wang; Natasha Raman; Ghali Lemtiri-Chlieh; Jinhee Chang; Shreya Jagtap; Dipanwita Dutta Chowdhury; Matthew Ballew; Francesca Anna Carrieri; Triet Nguyen; Katriana Nugent; Travis Peck; Michelle S. Levine; Aaron Chan; Christine Lam; Reem Malek; Tung Hoang; Ryan Phillips; ZhuoAn Cheng; Kekoa Taparra; Nick Connis; Christine L. Hann; Andrew Holland; Phuoc T. Tran; Audrey Lafargue; Hailun Wang
Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma
Terry J. Shackleford; Seethalakshmi Hariharan; Angelina V. Vaseva; Karina Alagoa; Maricruz Espinoza; Hemant K. Bid; Fuyang Li; Haihong Zhong; Doris A. Phelps; Ryan D. Roberts; Hakan Cam; Cheryl A. London; Denis C. Guttridge; Yidong Chen; Manjeet Rao; Yuzuru Shiio; Peter J. Houghton
Correction
Correction: Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer
Kuan-Chun Huang; Dinesh Chandra; Shannon McGrath; Vaishali Dixit; Chi Zhang; Jiayi Wu; Karen Tendyke; Huilan Yao; Renee Hukkanen; Noel Taylor; David Verbel; Dae-Shik Kim; Atsushi Endo; Thomas A. Noland; Yu Chen; Mark Matijevic; John Wang; Janna Hutz; Nadeem Sarwar; Francis G Fang; Xingfeng Bao
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