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1 November 2023
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CIDD-0149897, a brain permeable ERβ agonist, enhanced ERβ tumor suppressor function and showed anti-tumor activity in preclinical models of GBM. Graphic abstract was Created with BioRender.com (see graphical abstract). Read the full article on page 1248. - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
Commentary
First Disclosure
Preclinical Development of Brain Permeable ERβ Agonist for the Treatment of Glioblastoma
Uday P. Pratap; Michael Tidwell; Henriette U. Balinda; Nicholas A. Clanton; Xue Yang; Suryavathi Viswanadhapalli; Gangadhara R. Sareddy; Dong Liang; Huan Xie; Yidong Chen; Zhao Lai; Rajeshwar R. Tekmal; Stanton F. McHardy; Andrew J. Brenner; Ratna K. Vadlamudi
Review
Small Molecule Therapeutics
Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource
Joel Morris; Mark W. Kunkel; Stephen L. White; Donn G. Wishka; Omar D. Lopez; Lori Bowles; Penny Sellers Brady; Patricia Ramsey; Julie Grams; Tiffany Rohrer; Karen Martin; Thomas S. Dexheimer; Nathan P. Coussens; David Evans; Prabhakar Risbood; Dmitriy Sonkin; John D. Williams; Eric C. Polley; Jerry M. Collins; James H. Doroshow; Beverly A. Teicher
Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells
Haley M. Hardin; Christine T. Dinh; Julianne Huegel; Alejandra M. Petrilli; Olena Bracho; Abdulrahman M. Allaf; Matthias A. Karajannis; Anthony J. Griswold; Michael E. Ivan; Jacques Morcos; Sakir H. Gultekin; Fred F. Telischi; Xue Zhong Liu; Cristina Fernandez-Valle
Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1
Adrian Schwarzer; Matheus Oliveira; Marc-Jens Kleppa; Scott D. Slattery; Andy Anantha; Alan Cooper; Mark Hannink; Axel Schambach; Anneke Dörrie; Alexey Kotlyarov; Matthias Gaestel; Todd Hembrough; Jedd Levine; Michael Luther; Michael Stocum; Linsey Stiles; David M. Weinstock; Marc Liesa; Matthew J. Kostura
Combination Therapies to Improve the Efficacy of Immunotherapy in Triple-negative Breast Cancer
Maša Alečković; Zheqi Li; Ningxuan Zhou; Xintao Qiu; Bethlehem Lulseged; Pierre Foidart; Xiao-Yun Huang; Kodie Garza; Shaokun Shu; Nikolas Kesten; Rong Li; Klothilda Lim; Ana C. Garrido-Castro; Jennifer L. Guerriero; Jun Qi; Henry W. Long; Kornelia Polyak
Large Molecule Therapeutics
Efficacy and Safety of Glycosphingolipid SSEA-4 Targeting CAR-T Cells in an Ovarian Carcinoma Model
Hector J. Monzo; Kerttu Kalander; Marko M. Hyytiäinen; Endrit Elbasani; Johanna Wall; Lidia Moyano-Galceran; Jayendrakishore Tanjore Ramanathan; Joonas Jukonen; Pirjo Laakkonen; Ari Ristimäki; Joseph W. Carlson; Kaisa Lehti; Sahar Salehi; Pauli Puolakkainen; Caj Haglund; Hanna Seppänen; Sirpa Leppä; Päivi M. Ojala
Targeted Nanofitin-drug Conjugates Achieve Efficient Tumor Delivery and Therapeutic Effect in an EGFRpos Mouse Xenograft Model
Simon Huet; Magali Zeisser Labouebe; Rute Castro; Perrine Jacquot; Jessy Pedrault; Sébastien Viollet; Gaetan Van Simaeys; Gilles Doumont; Lionel Larbanoix; Egor Zindy; António E. Cunha; Leonardo Scapozza; Mathieu Cinier
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
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