Issues

X-ray structure of the parental 4-1BB binding domain (Fab1618) in ribbon (blue) bound to 4-1BB (green shades, surface projection) showing that the binding epitope includes residues in domain 1 (lemon green) and domain 2 (forest green) of 4-1BB. 11 hydrogen bonds were found between CDRH1 (yellow), CDRH2 (orange), CDRH3 (magenta), CDRL1 (red) and 4-1BB as shown in the close up picture to the left. The 4-1BBL (trimeric 4-1BBL, in surface projection, light purple) binding to 4-1BB has been superimposed to illustrate the binding sites of ALG.APV-527 and the 4-1BBL on 4-1BB are distinct. Read the full article on page 89.