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1 January 2023
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Cover Image
Cover Image
X-ray structure of the parental 4-1BB binding domain (Fab1618) in ribbon (blue) bound to 4-1BB (green shades, surface projection) showing that the binding epitope includes residues in domain 1 (lemon green) and domain 2 (forest green) of 4-1BB. 11 hydrogen bonds were found between CDRH1 (yellow), CDRH2 (orange), CDRH3 (magenta), CDRL1 (red) and 4-1BB as shown in the close up picture to the left. The 4-1BBL (trimeric 4-1BBL, in surface projection, light purple) binding to 4-1BB has been superimposed to illustrate the binding sites of ALG.APV-527 and the 4-1BBL on 4-1BB are distinct. Read the full article on page 89. - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Small Molecule Therapeutics
ER-851, a Novel Selective Inhibitor of AXL, Overcomes Resistance to Antimitotic Drugs
Shuntaro Tsukamoto; Naoko Hata Sugi; Kyoko Nishibata; Youya Nakazawa; Daisuke Ito; Sayo Fukushima; Takayuki Nakagawa; Kenji Ichikawa; Yu Kato; Dai Kakiuchi; Aya Goto; Machiko Itoh-Yagi; Tomoki Aota; Satoshi Inoue; Yoshinobu Yamane; Norio Murai; Hiroshi Azuma; Satoshi Nagao; Ken Sasai; Tsuyoshi Akagi; Toshio Imai; Junji Matsui; Tomohiro Matsushima
Combination of Ribociclib with BET-Bromodomain and PI3K/mTOR Inhibitors for Medulloblastoma Treatment In Vitro and In Vivo
Barbara Jonchere; Justin Williams; Frederique Zindy; Jingjing Liu; Sarah Robinson; Dana M. Farmer; Jaeki Min; Lei Yang; Jennifer L. Stripay; Yingzhe Wang; Burgess B. Freeman, III; Jiyang Yu; Anang A. Shelat; Zoran Rankovic; Martine F. Roussel
Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death
Laura J. Jenkins; Ian Y. Luk; W. Douglas Fairlie; Erinna F. Lee; Michelle Palmieri; Kael L. Schoffer; Tao Tan; Irvin Ng; Natalia Vukelic; Sharon Tran; Janson W.T. Tse; Rebecca Nightingale; Zakia Alam; Fiona Chionh; George Iatropoulos; Matthias Ernst; Shoukat Afshar-Sterle; Jayesh Desai; Peter Gibbs; Oliver M. Sieber; Amardeep S. Dhillon; Niall C. Tebbutt; John M. Mariadason
IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression
Dominic Lapadula; Bao Lam; Mizue Terai; Takahito Sugase; Ryota Tanaka; Eduardo Farias; Rama Kadamb; Melisa Lopez-Anton; Christian C. Heine; Bhavik Modasia; Julio A. Aguirre-Ghiso; Andrew E. Aplin; Takami Sato; Jeffrey L. Benovic
Large Molecule Therapeutics
The Bispecific Tumor Antigen-Conditional 4–1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies
Michelle H. Nelson; Sara Fritzell; Robert Miller; Doreen Werchau; Danielle Van Citters; Anneli Nilsson; Lynda Misher; Lill Ljung; Robert Bader; Adnan Deronic; Allison G. Chunyk; Lena Schultz; Laura A. Varas; Nadia Rose; Maria Håkansson; Jane Gross; Christina Furebring; Peter Pavlik; Anette Sundstedt; Niina Veitonmäki; Hilario J. Ramos; Anna Säll; Anna Dahlman; David Bienvenue; Laura von Schantz; Catherine J. McMahan; Maria Askmyr; Gabriela Hernandez-Hoyos; Peter Ellmark
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma
Rutulkumar Patel; Yvonne M. Mowery; Yi Qi; Alex M. Bassil; Matt Holbrook; Eric S. Xu; Cierra S. Hong; Jonathon E. Himes; Nerissa T. Williams; Jeffrey Everitt; Yan Ma; Lixia Luo; Sara R. Selitsky; Jennifer L. Modliszewski; Junheng Gao; Sin-Ho Jung; David G. Kirsch; Cristian T. Badea
Targeting Drug Resistance
Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer
Hajrah Khawaja; Rebecca Briggs; Cheryl H. Latimer; Mustasin Rassel; Daryl Griffin; Lyndsey Hanson; Alberto Bardelli; Frederica Di Nicolantonio; Simon S. McDade; Christopher J. Scott; Shauna Lambe; Manisha Maurya; Andreas U. Lindner; Jochen H.M. Prehn; Jose Sousa; Chris Winnington; Melissa J. LaBonte; Sarah Ross; Sandra Van Schaeybroeck
Acknowledgment to Reviewers
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