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Issues

Volume 21, Issue 9
1 September 2022
Molecular Cancer Therapeutics Cover Image for Volume 21, Issue 9
All Issues
ISSN 1535-7163
EISSN 1538-8514

Highlights

Selected Articles from This Issue
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Review

YES1: A Novel Therapeutic Target and Biomarker in Cancer
Irati Garmendia; Esther Redin; Luis M. Montuenga; Alfonso Calvo
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Small Molecule Therapeutics

Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma
Gina M. Castellano; Saman Zeeshan; Olga B. Garbuzenko; Hatim E. Sabaawy; Jyoti Malhotra; Tamara Minko; Sharon R. Pine
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Low-Dose JAK3 Inhibition Improves Antitumor T-Cell Immunity and Immunotherapy Efficacy
Floris Dammeijer; Mandy van Gulijk; Larissa Klaase; Menno van Nimwegen; Rachid Bouzid; Robin Hoogenboom; Maria E. Joosse; Rudi W. Hendriks; Thorbald van Hall; Joachim G. Aerts
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Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
Stacey L. Lehman; Theresa Wechsler; Kayla Schwartz; Lauren E. Brown; John A. Porco, Jr; William G. Devine; Jerry Pelletier; Uma T. Shankavaram; Kevin Camphausen; Philip J. Tofilon
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PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Jeetendra Kumar Nag; Hodaya Malka; Shoshana Sedley; Priyanga Appasamy; Tatyana Rudina; Tgst Levi; Amnon Hoffman; Chaim Gilon; Beatrice Uziely; Rachel Bar-Shavit
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CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II
Yilun Sun; Yang Zhang; Christopher W. Schultz; Yves Pommier; Anish Thomas
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Large Molecule Therapeutics

Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer
Stephen J. Gregson; Kathryn Pugh; Neki Patel; Shameen Afif-Rider; Balakumar Vijayakrishnan; Kathleen Santos; Jitka Riedl; Ian Hutchinson; Gyoung-Dong Kang; K. Phin Chooi; Rhiannon Beard; Lauren Adams; Conor S. Barry; Kathryn Ball; Luke A. Masterson; Mary McFarlane; John A. Hartley; Philip W. Howard
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An Enzymatically Cleavable Tripeptide Linker for Maximizing the Therapeutic Index of Antibody–Drug Conjugates
Summer Y.Y. Ha; Yasuaki Anami; Chisato M. Yamazaki; Wei Xiong; Candice M. Haase; Scott D. Olson; Jangsoon Lee; Naoto T. Ueno; Ningyan Zhang; Zhiqiang An; Kyoji Tsuchikama
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Anti-Extra Domain B Splice Variant of Fibronectin Antibody–Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade
Andrea T. Hooper; Kimberly Marquette; Chao-Pei Betty Chang; Jonathon Golas; Sadhana Jain; My-Hanh Lam; Magali Guffroy; Mauricio Leal; Hadi Falahatpisheh; Divya Mathur; Ting Chen; Kerry Kelleher; Kiran Khandke; Elwira Muszynska; Frank Loganzo; Edward Rosfjord; Judy Lucas; Zhengyan Kan; Chakrapani Subramanyam; Christopher O'Donnell; Dario Neri; Hans-Peter Gerber; Chad May; Puja Sapra
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Targeting Drug Resistance

Targeting Therapeutic Resistance and Multinucleate Giant Cells in CCNE1-Amplified HR-Proficient Ovarian Cancer
Shoumei Bai; Sarah E. Taylor; Mohd Azrin Jamalruddin; Stacy McGonigal; Edward Grimley; Dongli Yang; Kara A. Bernstein; Ronald J. Buckanovich
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Inhibition of Integrin αVβ3 Signaling Improves the Antineoplastic Effect of Bexarotene in Cutaneous T-Cell Lymphoma
Florencia Cayrol; Maria V. Revuelta; Mercedes Debernardi; Alejandra Paulazo; Jude M. Phillip; Nahuel Zamponi; Helena Sterle; María C. Díaz Flaqué; Cynthia Magro; Rossella Marullo; Erin Mulvey; Jia Ruan; Graciela A. Cremaschi; Leandro Cerchietti
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck.  None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1538-8514
  • Print ISSN 1535-7163

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