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Volume 20, Issue 9
1 September 2021
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    SENTI-101 is a novel allogeneic cell therapy for the treatment of peritoneal carcinomatosis, including advanced ovarian cancer. Genetically modified mesenchymal stem cells deliver IL-12 and IL-21 to peritoneal tumors, attracting and activating immune cells. Read the full article on page 1508.
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ISSN 1535-7163
EISSN 1538-8514

Highlights

Selected Articles from This Issue
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MCT First Disclosures

TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations
Brion W. Murray; Dayong Zhai; Wei Deng; Xin Zhang; Jane Ung; Vivian Nguyen; Han Zhang; Maria Barrera; Ana Parra; Jessica Cowell; Dong J. Lee; Herve Aloysius; Evan Rogers
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SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express IL12 and IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors
Alba Gonzalez-Junca; Frances D. Liu; Archana S. Nagaraja; Alyssa Mullenix; Chen-Ting Lee; Russell M. Gordley; Daniel O. Frimannsson; Ori Maller; Brian S. Garrison; Dharini Iyer; Anissa Benabbas; Tiffany A. Truong; Allison Quach; Mengxi Tian; Rowena Martinez; Rishi Savur; Alyssa Perry-McNamara; Denny Nguyen; Niran Almudhfar; Carmina Blanco; Christina Huynh; Asish Nand; Yu-An E. Lay; Ashita Magal; Sravani Mangalampalli; Philip J. Lee; Timothy K. Lu; Gary Lee
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Reviews

Current Development of Glioblastoma Therapeutic Agents
Zilai Wang; Norton P. Peet; Pin Zhang; Yuwei Jiang; Lijun Rong
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T-Cell Receptor Mimic Antibodies for Cancer Immunotherapy
Zhijian Duan; Mitchell Ho
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Strategies in Overcoming Homologous Recombination Proficiency and PARP Inhibitor Resistance
Nidhi Goel; McKenzie E. Foxall; Carly Bess Scalise; Jaclyn A. Wall; Rebecca C. Arend
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Small Molecule Therapeutics

Suppression of Extracellular Vesicle VEGF-C–mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor
Chu-An Wang; Chien-Feng Li; Rho-Chi Huang; Yo-Hua Li; Jing-Ping Liou; Shaw-Jenq Tsai
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VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases
Thomas L. Ekstrom; Nicholas M. Pathoulas; Amelia M. Huehls; Arun Kanakkanthara; Larry M. Karnitz
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ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer
Isacco Ferrarini; Anna Louie; Lanlan Zhou; Wafik S. El-Deiry
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Phase 0 Clinical Trial of Everolimus in Patients with Vestibular Schwannoma or Meningioma
Matthias A. Karajannis; Audrey Mauguen; Ekrem Maloku; Qingwen Xu; Erin M. Dunbar; Scott R. Plotkin; Anna Yaffee; Shiyang Wang; J. Thomas Roland; Chandranath Sen; Dimitris G. Placantonakis; John G. Golfinos; Jeffrey C. Allen; Nicholas A. Vitanza; Luis A. Chiriboga; Robert J. Schneider; Jingjing Deng; Thomas A. Neubert; Judith D. Goldberg; David Zagzag; Filippo G. Giancotti; Jaishri O. Blakeley
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Targeting TfR1 with the ch128.1/IgG1 Antibody Inhibits EBV-driven Lymphomagenesis in Immunosuppressed Mice Bearing EBV+ Human Primary B-cells
Laura E. Martínez; Tracy R. Daniels-Wells; Yu Guo; Larry I. Magpantay; Pierre V. Candelaria; Manuel L. Penichet; Otoniel Martínez-Maza; Marta Epeldegui
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β-Catenin Attenuation Inhibits Tumor Growth and Promotes Differentiation in a BRAFV600E-Driven Thyroid Cancer Animal Model
Minjing Zou; Huda A. BinEssa; Yousif H. Al-Malki; Suhad Al-Yahya; Monther Al-Alwan; Ibrahim Al-Jammaz; Khalid S.A. Khabar; Falah Almohanna; Abdullah M. Assiri; Brian F. Meyer; Ali S. Alzahrani; Futwan A. Al-Mohanna; Yufei Shi
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Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development
Sonja J. Gill; Paul W.G. Wijnhoven; Jacqueline H.L. Fok; Rebecca L. Lloyd; Jonathan Cairns; Joshua Armenia; Jenni Nikkilä; Alan Lau; Christopher J. Bakkenist; Susan M. Galbraith; Conchita Vens; Mark J. O'Connor
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Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer
Nyree Crawford; Katie J. Stott; Tamas Sessler; Christopher McCann; William McDaid; Andrea Lees; Cheryl Latimer; Jennifer P. Fox; Joanne M. Munck; Tomoko Smyth; Alpesh Shah; Vanessa Martins; Mark Lawler; Philip D. Dunne; Emma M. Kerr; Simon S. McDade; Vicky M. Coyle; Daniel B. Longley
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C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis
Kecheng Lei; Seong Su Kang; Eun Hee Ahn; Chun Chen; Jianming Liao; Xia Liu; Hua Li; Laura E. Edgington-Mitchell; Lingjing Jin; Keqiang Ye
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SHP2 Inhibition Enhances the Effects of Tyrosine Kinase Inhibitors in Preclinical Models of Treatment-naïve ALK-, ROS1-, or EGFR-altered Non–small Cell Lung Cancer
Hirohisa Kano; Eiki Ichihara; Hiromi Watanabe; Kazuya Nishii; Chihiro Ando; Takamasa Nakasuka; Kiichiro Ninomiya; Yuka Kato; Toshio Kubo; Kammei Rai; Kadoaki Ohashi; Katsuyuki Hotta; Masahiro Tabata; Yoshinobu Maeda; Katsuyuki Kiura
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DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models
Yanyan Jiang; Elaine Willmore; Stephen R. Wedge; Anderson J. Ryan
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The Radiosensitizing Effect of AZD0530 in Glioblastoma and Glioblastoma Stem-Like Cells
Hong Shik Yun; Jennifer Lee; Whoon Jong Kil; Tamalee R. Kramp; Philip J. Tofilon; Kevin Camphausen
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PARP and CDK4/6 Inhibitor Combination Therapy Induces Apoptosis and Suppresses Neuroendocrine Differentiation in Prostate Cancer
Cheng Wu; Shan Peng; Patrick G. Pilié; Chuandong Geng; Sanghee Park; Ganiraju C. Manyam; Yungang Lu; Guang Yang; Zhe Tang; Shakuntala Kondraganti; Daoqi Wang; Courtney W. Hudgens; Debora A. Ledesma; Mario L. Marques-Piubelli; Carlos A. Torres-Cabala; Jonathan L. Curry; Patricia Troncoso; Paul G. Corn; Bradley M. Broom; Timothy C. Thompson
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A Novel Nrf2 Pathway Inhibitor Sensitizes Keap1-Mutant Lung Cancer Cells to Chemotherapy
Di Zhang; Zhilin Hou; Kelly E. Aldrich; Lizbeth Lockwood; Aaron L. Odom; Karen T. Liby
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Large Molecule Therapeutics

Effective Killing of Acute Myeloid Leukemia by TIM-3 Targeted Chimeric Antigen Receptor T Cells
Wen-Hsin Sandy Lee; Zhiyong Ye; Alice M.S. Cheung; Y.P. Sharon Goh; Hsueh Ling Janice Oh; Ravisankar Rajarethinam; Siok Ping Yeo; Mun Kuen Soh; Esther Hian Li Chan; Lip Kun Tan; Soo-Yong Tan; Charles Chuah; Wee Joo Chng; John E. Connolly; Cheng-I Wang
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Anti-Glypican-1 Antibody–drug Conjugate as Potential Therapy Against Tumor Cells and Tumor Vasculature for Glypican-1–Positive Cholangiocarcinoma
Keiichiro Yokota; Satoshi Serada; Shigehiro Tsujii; Keisuke Toya; Tsuyoshi Takahashi; Takashi Matsunaga; Minoru Fujimoto; Sunao Uemura; Tsutomu Namikawa; Ichiro Murakami; Shogo Kobayashi; Hidetoshi Eguchi; Yuichiro Doki; Kazuhiro Hanazaki; Tetsuji Naka
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Recombinant Newcastle Disease Virus Immunotherapy Drives Oncolytic Effects and Durable Systemic Antitumor Immunity
James Harper; Shannon Burke; Jon Travers; Nicola Rath; Andrew Leinster; Christel Navarro; Ruth Franks; Rebecca Leyland; Kathy Mulgrew; Kelly McGlinchey; Lee Brown; Simon J. Dovedi; Jens-Oliver Koopmann; Nicholas M. Durham; Xing Cheng; Hong Jin; Jim Eyles; Robert W. Wilkinson; Danielle Carroll
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Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Real-world Experience of Olaparib Treatment in Patients with Ovarian Cancer: A Chinese Multicenter Study
Hong Zheng; Yunong Gao; Hongyan Guo; Li Li; Qingshui Li; Heng Cui; An Lin; Lixin Sun; Yuanjing Hu; Shan Kang; Wei Duan; Lingya Pan; Shuzhen Wang; Yingjie Yang; Yunxia Li; Weimin Kong; Yang Xiang; Xiaofei Tian; Bin Ling; Chunfang Ha; Wenpei Bai
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Models and Technologies

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction
David E. Durrant; Emily A. Smith; Ekaterina I. Goncharova; Nirmala Sharma; Patrick A. Alexander; Andrew G. Stephen; Curtis J. Henrich; Deborah K. Morrison
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