Issues

In this issue, Su, Chhabra, and colleagues demonstrate that PLK1, a mitotic regulator, and NOTCH1, a protein involved in cell fate determination, are positively correlated in melanoma and associated with patient survival. Further, combined inhibition of PLK1 and NOTCH was found to result in synergistic anti-proliferative effects. The cover image represents a tissue core from an in-house human melanoma tissue microarray containing multiple cases of melanomas and benign nevi. The cores were stained for S100 (green), PLK1 (red), NOTCH1 (orange), and DAPI (blue), followed by a multispectral quantitative fluorescence imaging analysis using Vectra scanner coupled with Nuance and InForm software. Read the full article on page 161.