Issues

In this issue, Zenke and colleagues introduce a novel pharmacological DNA-PK inhibitor M3814 (peposertib). M3814 blocks the repair of DNA double strand breaks, potently sensitizes cancer cells to radiation and regresses human tumor in mouse models of radiation therapy. The image shows that M3814 effectively prolongs the life of radiation-induced double strand breaks in FaDu xenograft tumors when given orally to nude mice. The abundant nuclear staining of γH2AX, as seen in this image, is indicative of unrepaired double strand breaks. Read the full article on page 1091.