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1 January 2020
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Cover Image
Cover Image
Chimeric antigen receptor T (CAR T) cells represent a new paradigm in cancer therapy. However, viral-based production of these CAR T cells is laborious and comes at a high cost. Therefore, Cai and colleagues sought to utilize minicircle DNA (mcDNA) to produce CAR T cells without the need for viruses. In the cover image, the authors demonstrate strong expression of PSCA on a prostate xenograft. CAR T cells derived using mcDNA targeted at this PSCA infiltrated the tumor and increased cytokine secretion. Read the article on page 178. - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
Review
Small Molecule Therapeutics
Author Choice
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
Lucy C. Riches; Antonio G. Trinidad; Gareth Hughes; Gemma N. Jones; Adina M. Hughes; Andrew G. Thomason; Paul Gavine; Andy Cui; Stephanie Ling; Jonathan Stott; Roger Clark; Samantha Peel; Pendeep Gill; Louise M. Goodwin; Aaron Smith; Kurt G. Pike; Bernard Barlaam; Martin Pass; Mark J. O'Connor; Graeme Smith; Elaine B. Cadogan
Author Choice
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage–Inducing or Repair–Compromising Therapies in Preclinical Cancer Models
Antje M. Wengner; Gerhard Siemeister; Ulrich Lücking; Julien Lefranc; Lars Wortmann; Philip Lienau; Benjamin Bader; Ulf Bömer; Dieter Moosmayer; Uwe Eberspächer; Sven Golfier; Christoph A. Schatz; Simon J. Baumgart; Bernard Haendler; Pascale Lejeune; Andreas Schlicker; Franz von Nussbaum; Michael Brands; Karl Ziegelbauer; Dominik Mumberg
Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Hilary A. Kenny; Madhu Lal-Nag; Min Shen; Betul Kara; Dominik A. Nahotko; Kristen Wroblewski; Sarah Fazal; Siquan Chen; Chun-Yi Chiang; Yen-Ju Chen; Kyle R. Brimacombe; Juan Marugan; Marc Ferrer; Ernst Lengyel
Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Xiaoyun Tang; Melinda Wuest; Matthew G.K. Benesch; Jennifer Dufour; YuanYuan Zhao; Jonathan M. Curtis; Alain Monjardet; Bertrand Heckmann; David Murray; Frank Wuest; David N. Brindley
A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
Zhenyu Yang; Dan Wang; James K. Johnson; Laura E. Pascal; Keita Takubo; Raghunandan Avula; Anish Bhaswanth Chakka; Jianhua Zhou; Wei Chen; Mingming Zhong; Qiong Song; Hui Ding; Zeyu Wu; Uma R. Chandran; Taber S. Maskrey; Joel B. Nelson; Peter Wipf; Zhou Wang
Verticillin A Causes Apoptosis and Reduces Tumor Burden in High-Grade Serous Ovarian Cancer by Inducing DNA Damage
Amrita Salvi; Chiraz Soumia M. Amrine; Julia R. Austin; KiAundra Kilpatrick; Angela Russo; Daniel Lantvit; Esther Calderon-Gierszal; Zachary Mattes; Cedric J. Pearce; Mark W. Grinstaff; Aaron H. Colby; Nicholas H. Oberlies; Joanna E. Burdette
Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo
Amber L. Fifield; Paul D. Hanavan; Douglas O. Faigel; Eduard Sergienko; Andrey Bobkov; Nathalie Meurice; Joachim L. Petit; Alysia Polito; Thomas R. Caulfield; Erik P. Castle; John A. Copland; Debabrata Mukhopadhyay; Krishnendu Pal; Shamit K. Dutta; Huijun Luo; Thai H. Ho; Douglas F. Lake
Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma
May Elbanna; Ashley R. Orillion; Nur P. Damayanti; Remi Adelaiye-Ogala; Li Shen; Kiersten Marie Miles; Sreenivasulu Chintala; Eric Ciamporcero; Swathi Ramakrishnan; Sheng-yu Ku; Karen Rex; Sean Caenepeel; Angela Coxon; Roberto Pili
Large Molecule Therapeutics
Author Choice
Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
Dina V. Hingorani; Matthew K. Doan; Maria F. Camargo; Joseph Aguilera; Seung M. Song; Donald Pizzo; Daniel J. Scanderbeg; Ezra E.W. Cohen; Andrew M. Lowy; Stephen R. Adams; Sunil J. Advani
Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors
Barbara Akla; Matthieu Broussas; Noureddine Loukili; Alain Robert; Charlotte Beau-Larvor; Martine Malissard; Nicolas Boute; Thierry Champion; Jean-Francois Haeuw; Alain Beck; Michel Perez; Cyrille Dreyfus; Mariya Pavlyuk; Eric Chetaille; Nathalie Corvaia
Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target
Toshihiro Kushibiki; Toru Nakamura; Masumi Tsuda; Takahiro Tsuchikawa; Koji Hontani; Kazuho Inoko; Mizuna Takahashi; Toshimichi Asano; Keisuke Okamura; Soichi Murakami; Yo Kurashima; Yuma Ebihara; Takehiro Noji; Yoshitsugu Nakanishi; Kimitaka Tanaka; Nako Maishi; Katsunori Sasaki; Woong-Ryeon Park; Toshiaki Shichinohe; Kyoko Hida; Shinya Tanaka; Satoshi Hirano
Cancer Biology and Translational Studies
ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2−/− Ovarian Cancer Cells
Lu Liu; Shurui Cai; Chunhua Han; Ananya Banerjee; Dayong Wu; Tiantian Cui; Guozhen Xie; Junran Zhang; Xiaoli Zhang; Eric McLaughlin; Ming Yin; Floor J. Backes; Arnab Chakravarti; Yanfang Zheng; Qi-En Wang
Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
Vindhya Udhane; Cristina Maranto; David T. Hoang; Lei Gu; Andrew Erickson; Savita Devi; Pooja G. Talati; Anjishnu Banerjee; Kenneth A. Iczkowski; Kenneth Jacobsohn; William A. See; Tuomas Mirtti; Deepak Kilari; Marja T. Nevalainen
Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor Models
Walid S. Kamoun; Anne-Sophie Dugast; James J. Suchy; Stephanie Grabow; Ross B. Fulton; James F. Sampson; Lia Luus; Michael Santiago; Alexander Koshkaryev; Gang Sun; Vasileios Askoxylakis; Eric Tam; Zhaohua Richard Huang; Daryl C. Drummond; Andrew J. Sawyer
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
Heather M. Moore; Heidi M. Savage; Carol O'Brien; Wei Zhou; Ethan S. Sokol; Michael E. Goldberg; Ciara Metcalfe; Lori S. Friedman; Mark R. Lackner; Timothy R. Wilson
Pralatrexate in Combination with Oxaliplatin in Advanced Esophagogastric Cancer: A Phase II Trial with Predictive Molecular Correlates
Usha Malhotra; Sarbajit Mukherjee; Christos Fountzilas; Patrick Boland; Austin Miller; Santosh Patnaik; Kristopher Attwood; Sai Yendamuri; Araba Adjei; Eric Kannisto; Mateusz Opyrchal; Peter Bushunow; Peter Loud; Renuka Iyer; Nikhil Khushalani
Identification of Expression Profiles Defining Distinct Prognostic Subsets of Radioactive-Iodine Refractory Differentiated Thyroid Cancer from the DECISION Trial
Jaume Capdevila; Ignacio Matos; Francesco M. Mancuso; Carmela Iglesias; Paolo Nuciforo; Carles Zafon; Hector G. Palmer; Zighereda Ogbah; Laura Muiños; Jorge Hernando; Guillermo Villacampa; Carol E. Peña; Josep Tabernero; Marcia S. Brose; Martin Schlumberger; Ana Vivancos
Acknowledgment to Reviewers
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