Skip Nav Destination
Issues
1 August 2019
-
Cover Image
Cover Image
ABOUT THE COVER
The treatment of N0 head and neck squamous cell carcinoma remains controversial between dissecting the neck or watchfully monitoring the condition. To generate a new option, Dr. Tanaka and colleagues developed a urokinase-type plasminogen activator-dependent oncolytic Sendai virus (“Bioknife”). In the cover image, GFP-expressing Bioknife is shown to be present in the tongue after injection into an orthotopic xenograft in mice. The authors further demonstrate Bioknife migrates to the sentinel lymph node where it suppressed lymph node metastasis. Read the full article on page 1430. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1535-7163
EISSN 1538-8514
Highlights
Commentary
Small Molecule Therapeutics
EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
Suryavathi Viswanadhapalli; Yiliao Luo; Gangadhara R. Sareddy; Bindu Santhamma; Mei Zhou; Mengxing Li; Shihong Ma; Rajni Sonavane; Uday P. Pratap; Kristin A. Altwegg; Xiaonan Li; Annabel Chang; Alejandra Chávez-Riveros; Kalarickal V. Dileep; Kam Y.J. Zhang; Xinlei Pan; Ramachandran Murali; Marek Bajda; Ganesh V. Raj; Andrew J. Brenner; Vijaya Manthati; Manjeet K. Rao; Rajeshwar R. Tekmal; Hareesh B. Nair; Klaus J. Nickisch; Ratna K. Vadlamudi
Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding
Saif Zaman; Xin Yu; Anthony F. Bencivenga; Adam R. Blanden; Yue Liu; Tracy Withers; Bing Na; Alan J. Blayney; John Gilleran; David A. Boothman; Stewart N. Loh; S. David Kimball; Darren R. Carpizo
Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression
Hiroaki Tanaka; Hideki Sakagami; Naoki Kaneko; Satoshi Konagai; Hiroko Yamamoto; Takahiro Matsuya; Masatoshi Yuri; Yosuke Yamanaka; Masamichi Mori; Masahiro Takeuchi; Hiroyuki Koshio; Masaaki Hirano; Sadao Kuromitsu
Author Choice
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition
Gary K. Scott; Christina Yau; Beatrice C. Becker; Sana Khateeb; Sophia Mahoney; Martin Borch Jensen; Byron Hann; Bryan J. Cowen; Scott D. Pegan; Christopher C. Benz
Large Molecule Therapeutics
Cancer Biology and Translational Studies
Author Choice
Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers
Adam Stewart; Elizabeth A. Coker; Sebastian Pölsterl; Alexandros Georgiou; Anna R. Minchom; Suzanne Carreira; David Cunningham; Mary ER. O'Brien; Florence I. Raynaud; Johann S. de Bono; Bissan Al-Lazikani; Udai Banerji
Vorinostat Potentiates 5-Fluorouracil/Cisplatin Combination by Inhibiting Chemotherapy-Induced EGFR Nuclear Translocation and Increasing Cisplatin Uptake
Geny Piro; Maria Serena Roca; Francesca Bruzzese; Carmine Carbone; Federica Iannelli; Alessandra Leone; Maria Grazia Volpe; Alfredo Budillon; Elena Di Gennaro
Oncolytic Herpes Virus Armed with Vasculostatin in Combination with Bevacizumab Abrogates Glioma Invasion via the CCN1 and AKT Signaling Pathways
Yusuke Tomita; Kazuhiko Kurozumi; Ji Young Yoo; Kentaro Fujii; Tomotsugu Ichikawa; Yuji Matsumoto; Atsuhito Uneda; Yasuhiko Hattori; Toshihiko Shimizu; Yoshihiro Otani; Tetsuo Oka; Balveen Kaur; Isao Date
Sentinel Lymph Node–Targeted Therapy by Oncolytic Sendai Virus Suppresses Micrometastasis of Head and Neck Squamous Cell Carcinoma in an Orthotopic Nude Mouse Model
Yuya Tanaka; Koji Araki; Shingo Tanaka; Yoshihiro Miyagawa; Hiroshi Suzuki; Daisuke Kamide; Masayuki Tomifuji; Kosuke Uno; Eiko Kimura; Taku Yamashita; Yasuji Ueda; Akihiro Shiotani
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer
Yuping Yin; Weizhen Liu; Qian Shen; Peng Zhang; Lulu Wang; Ruikang Tao; Hang Li; Xianxiong Ma; Xiangyu Zeng; Jae-Ho Cheong; Shumei Song; Jaffer A. Ajani; Gordon B. Mills; Kaixiong Tao; Guang Peng
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
Prognostic and Biologic Relevance of Clinically Applicable Long Noncoding RNA Profiling in Older Patients with Cytogenetically Normal Acute Myeloid Leukemia
Dimitrios Papaioannou; Deedra Nicolet; Hatice G. Ozer; Krzysztof Mrózek; Stefano Volinia; Paolo Fadda; Andrew J. Carroll; Jessica Kohlschmidt; Jonathan E. Kolitz; Eunice S. Wang; Richard M. Stone; John C. Byrd; Ramiro Garzon; Clara D. Bloomfield
Models and Technologies
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
RSS Feeds