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1 June 2019
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The BCL-2/XL pro-survival proteins compromise the effectiveness of cancer therapies. Here, Zoeller and colleagues provide in vivo evidence that neutralization of BCL-2/XL via navitoclax/ABT-263 enhances the cytotoxic effectiveness of the HER2-targeted antibody-drug conjugate T-DM1. To assess the pathological responses associated with combined treatments, the authors performed specialized histological staining. The cover represents microscopic analysis of a Masson's trichrome stained patient-derived xenograft treated with T-DM1 and navitoclax/ABT-263, and demonstrates substantial elimination of the tumor cells (red) and the emergence of a reactive stroma (blue). For more information, please see the article starting on page 1115. - PDF Icon PDF LinkTable of Contents
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ISSN 1535-7163
EISSN 1538-8514
Highlights
Small Molecule Therapeutics
Author Choice
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer
Shweta Joshi; Alok R. Singh; Kevin X. Liu; Timothy V. Pham; Muamera Zulcic; Dylan Skola; Hyun Bae Chun; Christopher K. Glass; Guillermo A. Morales; Joseph R. Garlich; Donald L. Durden
Large Molecule Therapeutics
A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy
Pottayil G. Sasikumar; Raghuveer K. Ramachandra; Srinivas Adurthi; Amit A. Dhudashiya; Sureshkumar Vadlamani; Koteswararao Vemula; Sriharibabu Vunnum; Leena K. Satyam; Dodderi S. Samiulla; Krishnaprasad Subbarao; Rashmi Nair; Rajeev Shrimali; Nagaraj Gowda; Murali Ramachandra
Discovery of A Novel EGFR-Targeting Antibody–Drug Conjugate, SHR-A1307, for the Treatment of Solid Tumors Resistant or Refractory to Anti-EGFR Therapies
Kaijie He; Jianyan Xu; Jindong Liang; Jiahua Jiang; Mi Tang; Xin Ye; Zhebin Zhang; Lei Zhang; Beibei Fu; Yan Li; Chang Bai; Lianshan Zhang; Weikang Tao
Cancer Biology and Translational Studies
Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus-1 with Integrin β1 Blocking Antibody OS2966
Tae Jin Lee; Mitra Nair; Yeshavanth Banasavadi-Siddegowda; Joseph Liu; Tejaswini Nallanagulagari; Alena Cristina Jaime-Ramirez; Jeffrey Yunhua Guo; Haroon Quadri; Jianying Zhang; Kurt H. Bockhorst; Manish K. Aghi; W. Shawn Carbonell; Balveen Kaur; Ji Young Yoo
Functional Analysis of Somatic Mutations Affecting Receptor Tyrosine Kinase Family in Metastatic Colorectal Cancer
Leslie Duplaquet; Martin Figeac; Frédéric Leprêtre; Charline Frandemiche; Céline Villenet; Shéhérazade Sebda; Nasrin Sarafan-Vasseur; Mélanie Bénozène; Audrey Vinchent; Gautier Goormachtigh; Laurence Wicquart; Nathalie Rousseau; Ludivine Beaussire; Stéphanie Truant; Pierre Michel; Jean-Christophe Sabourin; Françoise Galateau-Sallé; Marie-Christine Copin; Gérard Zalcman; Yvan De Launoit; Véronique Fafeur; David Tulasne
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
Genotyping of Circulating Tumor DNA Reveals the Clinically Actionable Mutation Landscape of Advanced Colorectal Cancer
Weiguo Cao; Yaping Xu; Lianpeng Chang; Yuhua Gong; Liren Li; Xianwei Mo; Xin Zhang; Guole Lin; Jiaolin Zhou; Dan Liu; Yuting Yi; Pingping Dai; Chenchen Zhu; Tao Liu; Yuxing Chu; Yanfang Guan; Yongsheng Chen; Jiayin Wang; Xuefeng Xia; Ling Yang; Xin Yi; Yong Cheng
Models and Technologies
Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing
Jasmien Cornillie; Agnieszka Wozniak; Haifu Li; Yannick Wang; Bram Boeckx; Yemarshet K. Gebreyohannes; Jasmien Wellens; Ulla Vanleeuw; Daphne Hompes; Marguerite Stas; Friedl Sinnaeve; Hazem Wafa; Diether Lambrechts; Maria Debiec-Rychter; Raf Sciot; Patrick Schöffski
Retractions
Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo
Girija Dasmahapatra; Dmitry Lembersky; Minkyeong P. Son; Hiral Patel; Derick Peterson; Elisa Attkisson; Richard I. Fisher; Jonathan W. Friedberg; Paul Dent; Steven Grant
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